David E. Hatoff, William G. M. Hardison – 1 July 1982 – The role of bile acids in the biliary secretion of alkaline phosphatase was studied. Rats with external bile fistulae were drained for 4 hr. After 2 hr, bile acid secretion fell progressively. Alkaline phosphatase secretion also decreased progressively during the period of drainage, suggesting that secretion of the two components was related. Each rat was then given an i.v. infusion of the taurine conjugate of either cholate, chenodeoxycholate, or ursodeoxycholate.

Susan J. Burwen, Albert L. Jones, Ira S. Goldman, Lawrence W. Way, Sussan Dejbakhsh – 1 July 1982 – We developed a simple and inexpensive method of perfusing small specimens of human liver in vitro that maintains short‐term tissue viability as judged by protein transport function and morphological features. The technique allows investigation of liver function at the cellular level in normal specimens and those with hepatobiliary disease.

Richard A. Weisiger – 1 July 1982

Marcel Patterson, Juan C. Gonzalez‐Vitale, Charles J. Fagan – 1 July 1982 – Cyst fluid from a patient with polycystic liver disease was obtained by needle aspiration using ultrasound guidance. The constituents of the fluid resembled the “bile salt‐independent” fraction of human bile and supports the hypothesis that such cysts are lined by a functioning, secretory bile duct epithelium.

David B. Flannery, Y. Edward Hsia, Barry Wolf – 1 July 1982

Giulio Marchesini, Marco Zoli, Cristina Dondi, Giampaolo Bianchi, Maurizio Cirulli, Emilio Pisi – 1 July 1982 – An amino acid mixture rich in branched‐chain amino acids and poor in aromatic amino acids was infused in six cirrhotics with altered plasma amino acid profile and normal mental state. The effect on muscle protein catabolism, as measured by urinary excretion of 3‐methylhistidine, was assessed during two consecutive 3‐day periods in which patients received the amino acid mixture alone or in a hypertonic dextrose solution.

Norman Gitlin, John L. Stauffer, Ronald C. Silvestri – 1 July 1982 – Fifty‐six patients with alcoholic cirrhosis and ascites were studied. The ascitic fluid was analyzed for pH, PO PCO2, glucose, protein, specific gravity, amylase, lactic dehydrogenase, white blood cell count, polymorphonuclear count, and cytology. It was also cultured aerobically and anaerobi‐cally. Simultaneously, arterial blood was analyzed for pH, PO2, and PCO2. Venous blood was analyzed for complete blood count, protein, aspartate transaminase, and it was also cultured under aerobic and anaerobic conditions.

John T. Galambos – 1 July 1982

Alan F. Hofmann – 1 July 1982

Raymond S. Koff, Claudio S. Pannuti, Marcelo L. G. Pereira, Bengt G. Hansson, Jules L. Dienstag, V. Amato NETO, Doris C. Wong, Robert H. Purcell – 1 July 1982 – During a 33‐month period, 295 patients with acute viral hepatitis were admitted to a state hospital for civil servants and their dependents in Sao Paulo, Brazil. Seventy‐nine per cent (232) were HBsAg negative. To define the contribution of non‐A, non‐B viral hepatitis to hepatitis morbidity in this population, further serological studies were performed in 147 confirmed HBsAg‐negative patients.