Humberto Reyes, María E. Wegmann, Nelly Segovia, Miguel Cuchacovich, Enrique Jadresic, Mónica Contador, Cecilia Fuentes, Mireya Melendez – 1 July 1982 – A possible association between intrahepatic cholestasis of pregnancy (ICP) and human‐leukocyte histocompatibility (HLA) antigens–used as genetic markers–was studied in 100 women with ICP compared to 100 multiparous women without a past history of the disease. Because we previously found a higher frequency of ICP in women with an overt Araucanian Indian descent than in Chilean Caucasoids, women from both ethnic groups were studied.

Kurt Jungermann, Norbert Katz – 1 May 1982 – Hepatocytes from the periportal (afferent) and perivenous (efferent) zones of the liver parenchyma differ in their enzyme content and subcellular structures.

Ronald E. Kleinman, Paul R. Harmatz, W. Allan Walker – 1 May 1982

Paul S. Monroe, Alfred L. Baker, John F. Schneider, Patricia S. Krager, Peter D. Klein, Dale Schoeller – 1 May 1982 – To determine whether the aminopyrine breath test (ABT) and serum bile acid concentrations reflect histologic severity of chronic hepatitis, 56 patients were prospectively evaluated with liver biopsies and ABTs, and the results were compared to results of standard liver chemistry tests; 44 of these patients also had fasting and 2‐hr postprandial serum bile acid measurements.

Masayasu Inoue, Kenji Okajima, Yoshimasa Morino – 1 May 1982 – When S‐carbamido(14C)methyl glutathione, a model compound of glutathione S‐conjugate, was administered i.v. to mice, radioactivity accumulated in the kidney within 1 to 2 min and then decreased gradually during the following 10 to 15 min with concomitant increase in hepatic radioactivity. Most hepatic radioactivity was accounted for by S‐carbamidomethyl cysteine and its N‐acetyl derivative, a mercapturic acid. The i.v.

Esteban Mezey, James J. Potter – 1 May 1982 – Castration was previously demonstrated to result in an increase in liver alcohol dehydrogenase and in rates of ethanol elimination in male rats. In this study, the effect of dihydrotestosterone, which is a more potent androgen than testosterone in the rat, was determined on liver alcohol dehydrogenase and ethanol elimination in the castrated rat. Dihydrotestosterone was found to be a substrate of liver alcohol dehydrogenase in the reductive direction and a competitive inhibitor of ethanol oxidation by the enzyme.

Beverly Barrett Dahms, Mary Petrelli, Robert Wyllie, Malcolm S. Henoch, Thomas C. Halpin, Stuart Morrison, Moonja Chung Park, Anthony S. Tavill – 1 May 1982 – Arteriohepatic dysplasia (syndromatic ductular hypoplasia, Alagille syndrome) is a condition of chronic cholestasis dating from infancy accompanied by characteristic facies, pulmonic stenosis, and other somatic abnormalities. The pathologic hallmark of arteriohepatic dysplasia is a paucity or absence of intrahepatic bile ducts, wildely regarded as a congenital deficiency.

1 May 1982

1 May 1982

George W. Mihaly, Denis J. Morgan, Richard Smallwood, Kenneth J. Hardy – 1 May 1982 – The steady‐state disposition of the β‐adrenoreceptor blocking drug, propranolol, and its metabolite, 4‐hydroxypropranolol, was studied in the anesthetized pregnant sheep near term. Following infusion of propranolol to the mother, steady‐state plasma concentrations were obtained at three dosage levels in each of the eight animals studied. Blood samples were obtained from: (i) maternal facial artery and hepatic vein; (ii) umbilical vein, and (iii) fetal carotid artery, portal vein, and right hepatic vein.