Kunihiko Ohnishi, Akihiko Mishima, Kunio Okuda – 1 November 1982 – The localization of the form of cytochrome P‐450 that is induced by phenobarbital was studied by direct immunofluorescence in the hepatocytes of rats pretreated with phenobarbital in comparison with saline‐treated rats. Specific fluorescence was seen in the hepatocyte cytoplasm in saline‐ and phenobarbital‐treated rats; a more concentrated halo of fluorescence was detected surrounding the nuclei in the centrilobular zones after phenobarbital treatment.

M. James Phillips, Chikara Oshio, Mamoru Miyairi, Hart Katz, Charles R. Smith – 1 November 1982 – Living hepatocytes observed under standard methods of cell isolation and culture show frequent active contractions of bile canaliculi when viewed by time‐lapse cinephotomicrography. This report gives details of the methods used to show the contractions. In addition, the characteristics of the contraction pattern are defined and analyzed. The contractions are regular, canalicular contraction time (systole) lasts 60 sec, and the most probable interval between contractions is 5 1/2 min.

Roberto J. Groszmann, David Kravetz, Jaime Bosch, Mortom Glickman, Jordi Bruix, James Bredfeldt, Harold O. Conn, Juan Rodes, Edward H. Storer – 1 November 1982 – This study was designed to investigate whether the addition of nitroglycerin to vasopressin infusion could avoid the deleterious systemic effects of vasopressin while maintaining or enhancing the therapeutic benefits of portal pressure reduction. The effect of nitroglycerin on splanchnic and systemic hemodynamics was studied in cirrhotic patients and portal hypertensive dogs receiving i.v. vasopressin. During i.v.

M. Sawkat ANWER, Dietmar Hegner – 1 September 1982 – Ion substitution studies were carried out in the isolated perfused rat liver to define the importance of solvent drag and diffusion in bile acid‐dependent bile formation. Two different methods, namely single injection (20 μmoles) and continuous infusions at 0.4, 0.8, 1.2, and 1.6 μmoles per min taurocholate (TC), were used to determine the bile acid‐dependent bile flow (BADF). Both methods gave essentially the same results. Replacement of Na+ (146 mM) by 120 or 146 mM Li+ and Cl− (127 mM) by 120 mM NO3− increased BADF significantly.

C. S. Davidson – 1 September 1982

Irwin H. Rosenberg – 1 September 1982

Luis Montan̄to, Guido C. Miescher, Alison H. Goodall, Karl H. Wiedmann, George Janossy, Howard C. Thomas – 1 September 1982 – An analysis of the expression of the histocompatibility antigens in the livers of patients with chronic hepatitis B virus infection and normal subjects has demonstrated an increased expression of HLA‐A,B,C antigens on the hepatocytes of patients with a low level of viral replication (HBe antibody positive) as compared with patients who exhibit a high level of viral replication (HBe antigen positive) and controls.

Richard J. Grand – 1 September 1982

Irwin H. Rosenberg – 1 September 1982

Hyman J. Zimmerman, Kamal G. Ishak – 1 September 1982 – Analyses of 23 fatal instances of hepatic injury in patients taking valproic acid reveals that all but three were less than 20 years old, and all but four had been taking the drugs for more than 1 month. Convulsions, facial edema, lassitude, and vomiting were prominent clinical features. Hypoglycemia was recorded in six patients. Rash and eosinophilia were not seen. Values for transaminases were modestly elevated in most patients. Most levels of SGOT were below 500 IU, and SGPT levels were below 200 IU.