Antiviral Treatment of Chronic Hepatitis B Virus Infection: Infectious Virus Cannot Be Detected in Patient Serum after Permanent Responses to Treatment

George H. Scullard, Harry B. Greenberg, Joseph L. Smith, Peter B. Gregory, Thomas C. Merigan, William S. Robinson – 1 January 1982 – Fourteen chimpanzees were inoculated with pre‐ and posttreatment sera from seven patients with persistent hepatitis B virus infection and chronic hepatitis who had permanent responses of their infection to treatment with interferon and/or adenine arabinoside.

Bile Acid Metabolism in Cirrhosis. VIII. Quantitative Evaluation of Bile Acid Synthesis From [7β‐3H]7α‐Hydroxycholesterol and [G‐3H]26‐Hydroxycholesterol

Marc Goldman, Z. Reno Vlahcevic, Charles C. Schwartz, Jan Gustafsson, Leon Swell – 1 January 1982 – In order to evaluate more definitively the observed aberrations in the synthesis of cholic and chenodeoxycholic acids in patients with advanced cirrhosis, two bile acid biosynthesis pathways were examined by determining the efficiency of conversion of [3H]7α‐hydroxycholesterol and [3H] 26‐hydroxycholesterol to primary bile acids. Bile acid kinetics were determined by administration of [14C]cholic and [14C]chenodeoxycholic acids.

Morphologic Study of Intermediate Filaments in Rat Hepatocytes

Samuel W. French, Isao Kondo, Tetsuya Irie, Thomas J. Ihrig, Nancy Benson, Robert Munn – 1 January 1982 – Rat livers perfused with 0.5% Triton X‐100 for 15 to 90 min followed by 1% sodium dodecyl sulfate for 30 min were studied by electron microscopy and polyaerylamide gel electrophoresis. After 15 min of perfusion, a rich network of intermediate filaments and microtubules was visualized in the cytoplasm of hepatocytes. Using stereopairs, branching was visualized. Connections of filaments were noted with nuclei, centrioles, microtubules, vesicles, and rough endoplasmic reticulum.

The Effect of Portal Diversion on the Early Stages of Liver Carcinogenesis in the Rat

Lorne E. Rotstein, Leonard Makowka, George Lee, Emmanuel Farber – 1 January 1982 – The effect of portal diversion by ameroid constriction was studied in the carcinogenic process in the rat after initiation of foci by diethylnitrosamine and after the establishment of putative preneoplastic nodules. Portal diversion or portal diversion plus partial hepatectomy did not act to promote or select for the development of nodules. Furthermore, portal diversion did not alter the natural history of established nodules.

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