Effects of therapeutic paracentesis on systemic and hepatic hemodynamics and on renal and hormonal function

Douglas M. Simon, J. Ross McCain, Herbert L. Bonkovsky, James O. Wells, Diane K. Hartle, John T. Galambos – 1 May 1987 – Thirteen patients with cirrhosis and tense ascites (six with and seven without peripheral edema) underwent 4‐ to 15‐liter paracentesis without intravenous “colloid” replacement. Cardiac output increased from 6.6 ± 0.7 liters per min at baseline to 8.2 ± 0.7 liters per min (p < 0.003) 1 hr after large‐volume paracentesis completion and fell to 7.5 ± 0.69 liters per min (p < 0.05 vs. baseline, p < 0.02 vs. 1 hr) 24 hr after large‐volume paracentesis completion.

Propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis: A prospective study of factors associated with rebleeding

Thierry Poynard, Didier Lebrec, Patrick Hillon, Raymond Sayegh, Jacques Bernuau, Sylvie Naveau, Jean‐Claude Chaput, Claude Klepping, Bernard Rueff, Jean‐Pierre Benhamou – 1 May 1987 – In a previous randomized trial, we demonstrated that propranolol prevented recurrent gastrointestinal bleeding in patients with cirrhosis. We have undertaken the present study in a new group of patients to ascertain the factors associated with rebleeding. Among 232 patients with cirrhosis admitted for gastrointestinal bleeding, 127 were included.

Effect of complete sulfation of bile acids on bile formation in rats

Ibrahim M. Yousef, Stephen G. Barnwell, Beatriz Tuchweber, Andrée Weber, Claude C. Roy – 1 May 1987 – The effect of sulfation of common bile acids on the formation of bile was investigated in male rats by infusing them with the sulfate esters of cholic, chenodeoxycholic, deoxycholic, lithocholic or dehydrocholic acid in four step‐wise, increasing doses. Each dose was infused for 30 min and bile collected every 10 min.

Human hepatocellular carcinoma: Cross‐reactive and idiotypic antigens associated with malignant transformation of epithelial cells

Karl H. Wiedmann, Ludwik K. Trejdosiewicz, Jennifer Southgate, Howard C. Thomas – 1 May 1987 – Monoclonal antibodies were isolated following immunization with the HBsAg and α‐fetoprotein‐secreting human hepatoma PLC/PRF/5 (“Alexander”) cell line. Three antibodies (K‐PLC1, K‐PLC2 and K‐PLC3) showed evidence of carcinoma‐associated reactivity by indirect immunofluorescence. Antibodies K‐PLC2 and K‐PLC3 reacted only with PLC/PRF/5 cells, but not with any other normal or malignant cell type tested, including the Hep/G2 hepatoma cell line.

The role of propranolol in congestive gastropathy of portal hypertension

Shorland W. Hosking, Hugh J. Kennedy, Ian Seddon, David R. Triger – 1 May 1987 – Heavy diffuse bleeding from congested gastric mucosa (congestive gastropathy) was treated by propranolol (dose = 24 to 480 mg per day) in 14 consecutive patients with portal hypertension. Thirteen patients (93%) stopped bleeding within 3 days. Gastric mucosal cherry red spots (a sign of severe gastropathy) were unchanged in 5 patients, became less obvious in 4 and appearances returned to normal in 5.

The aminopyrine breath test does not correlate with histologic disease severity in patients with cholestasis

Alfred L. Baker, Patricia S. Krager, Alvin N. Kotake, Dale A. Schoeller – 1 May 1987 – To determine whether the aminopyrine breath test can be used to document the presence of cirrhosis in patients with cholestatic liver disease, 19 patients (13 primary biliary cirrhosis, 4 sclerosing cholangitis and 2 chronic extrahepatic bile duct obstruction) underwent clinical and biochemical evaluations, liver biopsies and an aminopyrine breath test. Results were compared with those in 10 patients with biopsy‐proven chronic active hepatitis with bridging and/or cirrhosis and in 22 healthy subjects.

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