The significance of IgM antibodies to hepatitis B core antigen in hepatitis B carriers and hepatitis B‐associated chronic liver disease

S. Victor Feinman, Lacy R. Overby, Barnet Berris, Kurt Chau, Charles A. Schable, James E. Maynard – 1 November 1982 – IgM antibody to hepatitis B core antigen (IgM anti‐HBc) was determined in 60 patients whose serum was positive for hepatitis B surface antigen (HBsAg) and 18 patients whose serum was negative for HBsAg, but positive for antibody to hepatitis B core antigen (anti‐HBc). Two radioimmunoassays were done utilizing either anti‐u antibody to capture IgM or Staphylococcus A protein to separate IgG and IgM.

Ursodeoxycholic acid vs. chenodeoxycholic acid as cholesterol gallstone‐dissolving agents: A comparative randomized study

Enrico Roda, Franco Bazzoli, Antonio M. Morselli Labate, Giuseppe Mazzella, Aldo Roda, Claudia Sama, Davide Festi, Rita Aldini, Francesco Taroni, Luigi Barbara – 1 November 1982 – Cholesterol gallstones are dissolved in man by chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA). To test the comparative efficacy of these two cholelitholytic bile acids, 223 gallstone patients were randomly treated with either UDCA or CDCA at two different doses: 7 to 8 mg per kg per day and 14 to 15 mg per kg per day.

Studies to elucidate the thyroid hormone dependence of morris hepatoma 44

Raphael Pollack, Shaindel Y. Mishkin, Harold P. Morris, Mordechai A. Yalovsky, Seymour Mishkin – 1 November 1982 – The objective of these studies was to elucidate further the mechanisms of the thyroid dependency of Morris Hepatoma 44. In vivo experiments indicated that while exogenous thyroxine (8 μg per kg) reversed the hypothyroid‐mediated inhibition of primary hepatoma growth, no such effect was noted with the administration of ovine prolactin (100 μg per kg s.c.) and bovine growth hormone (100 μg per kg, s.c).

The mechanism of biliary excretion of α1‐acid glycoprotein in the rat: Evidence for a molecular weight‐dependent, nonreceptor‐mediated pathway

Peter Thomas, Carol A. Toth, Norman Zamcheck – 1 November 1982 – The transport of human α1‐acid glycoprotein from the circulation to the bile has been studied in the rat. Biliary excretion was proportional to the i.v. injected dose, and the percentage excreted remained constant. The amount excreted in the bile (over 4 hr) was inversely related to the rate of hepatic (hepatocyte) uptake and the galactose receptor which is specific for asialo glycoproteins was not involved.

Pigment gallstone disease: Summary of the national institutes of health—international workshop

Bruce W. Trotman, Roger D. Soloway – 1 November 1982 – This report summarizes the proceedings of the first National Institutes of Health—International Workshop on Pigment Gallstone Disease. The meeting held at the University of Pennsylvania in May, 1981 consisted of eight sessions in which the following aspects of pigment gallstone disease were discussed: (a) classification; (b) epidemiology; (c) radiographic assessment; (d) gallstone composition; (e) composition of bile; (f) pathogenesis; (g) animal models, genetics, and computer analysis, and (h) medical treatment.

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