IgM anti‐HBc in anti‐HBe positive chronic type B hepatitis with acute exacerbations

Kazuhiko Koike, Shiro Iino, Kiyohiko Kurai, Keiji Mitamura, Yasuo Endo, Hiroshi Oka – 1 May 1987 – IgM anti‐HBc was measured by radioimmunoassay in serially collected serum samples during 20 acute exacerbations which developed in 14 patients with anti‐HBe positive chronic type B hepatitis. IgM anti‐HBc became positive in 12 of the 14 (86%) patients and in 18 of the 20 (90%) exacerbations, and elevation of IgM anti‐HBc which was believed to be significant was also observed in the remaining two patients.

Oleic acid‐induced cholelithiasis in the rabbit: Conversion of dietary oleic acid to cholestanol as a cause of calcium‐bile salt gallstones

Sum P. Lee, Cliff Tasman‐Jones, Valerie F. Carlisle – 1 May 1987 – Rabbits fed a diet rich in oleic acid develop gallstones consisting of calcium salts of (5α)‐glyco‐allodeoxycholic acid. To study the metabolic pathway of oleic acid, we followed the changes in plasma, hepatic and biliary lip‐ids in this animal model. In addition, to also determine the role played by intestinal microflora on biliary lipid metabolism, we added kanamycin to the oleic acid diet. Oleic acid‐fed rabbits rapidly developed hypercholes‐terolemia.

Anti‐liver‐kidney microsome antibody is a marker for the rat hepatocyte endoplasmic reticulum

Carmen De Lemos‐Chiarandini, Fernando Alvarez, Olivier Bernard, Jean Claude Homberg, Gert Kreibich – 1 May 1987 – Human sera, containing anti‐liver‐kidney microsome antibody as demonstrated by indirect immunofluorescence, were obtained from a subgroup of young patients with autoimmune chronic hepatitis. The anti‐liver‐kidney microsome antibody‐positive sera were used to study the localization of the liver‐kidney microsome antigen in hepatocytes.

The aminopyrine breath test does not correlate with histologic disease severity in patients with cholestasis

Alfred L. Baker, Patricia S. Krager, Alvin N. Kotake, Dale A. Schoeller – 1 May 1987 – To determine whether the aminopyrine breath test can be used to document the presence of cirrhosis in patients with cholestatic liver disease, 19 patients (13 primary biliary cirrhosis, 4 sclerosing cholangitis and 2 chronic extrahepatic bile duct obstruction) underwent clinical and biochemical evaluations, liver biopsies and an aminopyrine breath test. Results were compared with those in 10 patients with biopsy‐proven chronic active hepatitis with bridging and/or cirrhosis and in 22 healthy subjects.

The role of propranolol in congestive gastropathy of portal hypertension

Shorland W. Hosking, Hugh J. Kennedy, Ian Seddon, David R. Triger – 1 May 1987 – Heavy diffuse bleeding from congested gastric mucosa (congestive gastropathy) was treated by propranolol (dose = 24 to 480 mg per day) in 14 consecutive patients with portal hypertension. Thirteen patients (93%) stopped bleeding within 3 days. Gastric mucosal cherry red spots (a sign of severe gastropathy) were unchanged in 5 patients, became less obvious in 4 and appearances returned to normal in 5.

Human hepatocellular carcinoma: Cross‐reactive and idiotypic antigens associated with malignant transformation of epithelial cells

Karl H. Wiedmann, Ludwik K. Trejdosiewicz, Jennifer Southgate, Howard C. Thomas – 1 May 1987 – Monoclonal antibodies were isolated following immunization with the HBsAg and α‐fetoprotein‐secreting human hepatoma PLC/PRF/5 (“Alexander”) cell line. Three antibodies (K‐PLC1, K‐PLC2 and K‐PLC3) showed evidence of carcinoma‐associated reactivity by indirect immunofluorescence. Antibodies K‐PLC2 and K‐PLC3 reacted only with PLC/PRF/5 cells, but not with any other normal or malignant cell type tested, including the Hep/G2 hepatoma cell line.

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