The Role of Hepatocyte Enlargement in Hepatic Pressure in Cirrhotic and Noncirrhotic Alcoholic Liver Disease

Laurence M. Blendis, Hector Orrego, Ian R. Crossley, Joan E. Blake, Alan Medline, Yedy Israel – 1 September 1982 – The relationship between hepatocyte enlargement and intrahepatic and portal pressures was studied in a group of 163 patients with alcoholic liver disease presenting liver biopsy abnormalities, including 91 cirrhotics. For the complete group, hepatocyte surface areas were significantly correlated (r = 0.73, p < 0.0001) with pressure. Cirrhotics as a group had a mean average pressure of 20.4 ± 0.9 mm Hg, while that for noncirrhotics was 11.7 ± 0.8 mm Hg (p < 0.0001).

Visual Evoked Potentials in Encephalopathy Induced by Galactosamine, Ammonia, Dimethyldisulfide, and Octanoic Acid

Maria L. Zeneroli, Ezio Ventura, Mario Baraldi, Alessandro Penne, Elena Messori, Leslie Zieve – 1 September 1982 – Visual evoked potentials were utilized to examine the neuronal transmission changes provoked by galactosamine‐induced hepatic encephalopathy and by administration in normal animals of toxins presumably involved in the pathogenesis of hepatic encepalopathy.

Taurocholate Transport by Rat Liver Sinusoidal Membrane Vesicles: Evidence of Sodium Cotransport

Masayasu Inoue, Rolf Kinne, Thao Tran, Irwin M. Arias – 1 September 1982 – To elucidate the first step in the vectorial transport of bile acids by the liver, plasma membrane vesicles were isolated from rat liver by differential and sucrose‐Ficoll density gradient centrifugation. The membranes were selectively enriched 20‐fold in Na+,K+−ATPase activity, a marker of sinusoidal plasma membranes. Electron microscopy of pellets from sinusoidal membrane fraction did not reveal other organelles.

Histologic Observations in Human Hepatitis Non‐A, Non‐B

Hans P. Dienes, Hans Popper, Wolfgang Arnold, Hartmut Lobeck – 1 September 1982 – Specimens from 57 patients with acute or chronic hepatitis non‐A, non‐B (HNANB), mostly mild to moderate, were studied by light and, in 22 instances, by electron microscopy. They were compared to specimens of hepatitis A and hepatitis B on file or obtained simultaneously with the HNANB cases. In the HNANB material, two types of light‐microscopic lesions were noted in the lobular parenchyma singly or in combination.

Control of Cellular Division and Development. Proceedings of the ICN‐UCLA Symposium held in Keystone, Colorado, March 2–8, 1980. Edited by Dennis Cunningham, Eugene Goldwasser, James Watson, and C. Fred Fox. In 2 volumes, 1044 pp., illustrated. New York:

Discrepancy Between Ultrasound and Oral Cholecystography in the Assessment of Gallstone Dissolution

Theodore F. Shapero, Irving E. Rosen, Stephanie R. Wilson, Murray M. Fisher – 1 September 1982 – The Sunnybrook Medical Centre Gallstone Study is a randomized, controlled, double‐blind study of chenodeoxycholic acid for dissolution of radiolucent gallstones. Of the first 22 patients whosestones were apparently totally dissolved on oral cholecystography, seven were found to have residual small stone fragments on ultrasound examination of the gallbladder. Continuing chenotherapy was unsuccessful in dissolving these fragments.

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