Beverly Barrett Dahms, Mary Petrelli, Robert Wyllie, Malcolm S. Henoch, Thomas C. Halpin, Stuart Morrison, Moonja Chung Park, Anthony S. Tavill – 1 May 1982 – Arteriohepatic dysplasia (syndromatic ductular hypoplasia, Alagille syndrome) is a condition of chronic cholestasis dating from infancy accompanied by characteristic facies, pulmonic stenosis, and other somatic abnormalities. The pathologic hallmark of arteriohepatic dysplasia is a paucity or absence of intrahepatic bile ducts, wildely regarded as a congenital deficiency.

1 May 1982

1 May 1982

George W. Mihaly, Denis J. Morgan, Richard Smallwood, Kenneth J. Hardy – 1 May 1982 – The steady‐state disposition of the β‐adrenoreceptor blocking drug, propranolol, and its metabolite, 4‐hydroxypropranolol, was studied in the anesthetized pregnant sheep near term. Following infusion of propranolol to the mother, steady‐state plasma concentrations were obtained at three dosage levels in each of the eight animals studied. Blood samples were obtained from: (i) maternal facial artery and hepatic vein; (ii) umbilical vein, and (iii) fetal carotid artery, portal vein, and right hepatic vein.

Mauro Podda, Massimo Zuin, Maria L. Dioguardi, Susanna Festorazzi, Nicola Dioguardi – 1 May 1982 – The effects on biliary lipids of 10 mg per kg per day of chenodeoxycholic acid (CDCA), 10 mg per kg per day of ursodeoxycholic acid (UDCA), and their equimolar combination (5 mg per kg per day of each), all administered for 45 to 60 days, were investigated in 18 patients with gallstones in a double‐blind study with a balanced latin square design.

Helmer Ring‐Larsen, Birger Hesse, Jens H. Henriksen, Niels J. Christensen – 1 May 1982 – Systemic and renal neurovascular reactivity was investigated in eight patients with cirrhosis and in eight control subjects with fatty liver during postural changes. In the supine position, mean renal blood flow averaged 1.51 and 2.97 ml per gm per min in patients and controls, respectively (p < 0.02).

Charles S. Davidson, Samuel W. French – 1 May 1982

Ruth V. W. Dimlich, Samuel F. Townsend, Frank D. Reilly – 1 May 1982 – Blood glucose, hepatic glycogen, and mean carotid blood pressure were determined in anesthetized Sprague‐Dawley rats receiving an i.v. infusion of Compound 48/80, pilocarpine, or Ringer's solution as a control. Histochemical determinations of the integrity and number of hepatic mast cells and hepatic glycogen content also were performed at the light microscopic level, and the results compared to those from rats whose livers were treated topically with each of these compounds.

John M. Vierling, Paul D. Berk, Alan F. Hofmann, James F. Martin, Allan W. Wolkoff, Bruce F. Scharschmidt – 1 May 1982 – Fasting levels of cholic acid conjugates were determined by radioimmunoassay in the serum of 24 patients with extensively documented Gilbert's syndrome and in 98 healthy controls without unconjugated hyperbilirubinemia. The Gilbert's syndrome patients studied included all three subtypes, as determined from studies of the plasma disappearance kinetics of sulf obromophthalein and indocyanine green.

Paul R. Harmatz, Ronald E. Kleinman, Bruce W. Bunnell, Kurt J. Bloch, W. Allan Walker – 1 May 1982 – The formation and clearance of circulating IgA immune complexes from blood to bile was investigated in this study. The i.v. injection of either MOPC‐315, an IgA M‐component with anti‐dinitrophenyl (DNP) specificity, or TEPC‐15, an IgA M‐component of a different specificity, was followed by i.v. injection of 125I‐DNP10‐bovine serum albumin (BSA) as the antigen.