James S. Dooley, Barry J. Potter, Howard C. Thomas, Sheila Sherlock – 1 May 1982 – In the rat, dimeric immunoglobulin A (dIgA) is cleared rapidly from the systemic circulation into bile by vesicular transport through the hepatocyte. Whether such transfer of dIgA occurs in man is controversial. The fate of dIgA and monomeric IgA (mIgA) was studied in rats with biliary drainage, and in parallel in 4 patients, 3 of whom had biliary drainage. Human dIgA and mIgA were prepared from myeloma sera and labeled with radioisotopes of iodine.

Paul R. Harmatz, Ronald E. Kleinman, Bruce W. Bunnell, Kurt J. Bloch, W. Allan Walker – 1 May 1982 – The formation and clearance of circulating IgA immune complexes from blood to bile was investigated in this study. The i.v. injection of either MOPC‐315, an IgA M‐component with anti‐dinitrophenyl (DNP) specificity, or TEPC‐15, an IgA M‐component of a different specificity, was followed by i.v. injection of 125I‐DNP10‐bovine serum albumin (BSA) as the antigen.

John M. Vierling, Paul D. Berk, Alan F. Hofmann, James F. Martin, Allan W. Wolkoff, Bruce F. Scharschmidt – 1 May 1982 – Fasting levels of cholic acid conjugates were determined by radioimmunoassay in the serum of 24 patients with extensively documented Gilbert's syndrome and in 98 healthy controls without unconjugated hyperbilirubinemia. The Gilbert's syndrome patients studied included all three subtypes, as determined from studies of the plasma disappearance kinetics of sulf obromophthalein and indocyanine green.

Ruth V. W. Dimlich, Samuel F. Townsend, Frank D. Reilly – 1 May 1982 – Blood glucose, hepatic glycogen, and mean carotid blood pressure were determined in anesthetized Sprague‐Dawley rats receiving an i.v. infusion of Compound 48/80, pilocarpine, or Ringer's solution as a control. Histochemical determinations of the integrity and number of hepatic mast cells and hepatic glycogen content also were performed at the light microscopic level, and the results compared to those from rats whose livers were treated topically with each of these compounds.

Charles S. Davidson, Samuel W. French – 1 May 1982

Helmer Ring‐Larsen, Birger Hesse, Jens H. Henriksen, Niels J. Christensen – 1 May 1982 – Systemic and renal neurovascular reactivity was investigated in eight patients with cirrhosis and in eight control subjects with fatty liver during postural changes. In the supine position, mean renal blood flow averaged 1.51 and 2.97 ml per gm per min in patients and controls, respectively (p < 0.02).

Mauro Podda, Massimo Zuin, Maria L. Dioguardi, Susanna Festorazzi, Nicola Dioguardi – 1 May 1982 – The effects on biliary lipids of 10 mg per kg per day of chenodeoxycholic acid (CDCA), 10 mg per kg per day of ursodeoxycholic acid (UDCA), and their equimolar combination (5 mg per kg per day of each), all administered for 45 to 60 days, were investigated in 18 patients with gallstones in a double‐blind study with a balanced latin square design.

George W. Mihaly, Denis J. Morgan, Richard Smallwood, Kenneth J. Hardy – 1 May 1982 – The steady‐state disposition of the β‐adrenoreceptor blocking drug, propranolol, and its metabolite, 4‐hydroxypropranolol, was studied in the anesthetized pregnant sheep near term. Following infusion of propranolol to the mother, steady‐state plasma concentrations were obtained at three dosage levels in each of the eight animals studied. Blood samples were obtained from: (i) maternal facial artery and hepatic vein; (ii) umbilical vein, and (iii) fetal carotid artery, portal vein, and right hepatic vein.

1 May 1982

1 May 1982