Importance of Solvent Drag and Diffusion in Bile Acid‐Dependent Bile Formation: Ion Substitution Studies in Isolated Perfused Rat Liver
M. Sawkat ANWER, Dietmar Hegner – 1 September 1982 – Ion substitution studies were carried out in the isolated perfused rat liver to define the importance of solvent drag and diffusion in bile acid‐dependent bile formation. Two different methods, namely single injection (20 μmoles) and continuous infusions at 0.4, 0.8, 1.2, and 1.6 μmoles per min taurocholate (TC), were used to determine the bile acid‐dependent bile flow (BADF). Both methods gave essentially the same results. Replacement of Na+ (146 mM) by 120 or 146 mM Li+ and Cl− (127 mM) by 120 mM NO3− increased BADF significantly.
HLA in Chileans with Intrahepatic Cholestasis of Pregnancy
Humberto Reyes, María E. Wegmann, Nelly Segovia, Miguel Cuchacovich, Enrique Jadresic, Mónica Contador, Cecilia Fuentes, Mireya Melendez – 1 July 1982 – A possible association between intrahepatic cholestasis of pregnancy (ICP) and human‐leukocyte histocompatibility (HLA) antigens–used as genetic markers–was studied in 100 women with ICP compared to 100 multiparous women without a past history of the disease. Because we previously found a higher frequency of ICP in women with an overt Araucanian Indian descent than in Chilean Caucasoids, women from both ethnic groups were studied.
Notices
1 July 1982
Hepatocellular Carcinoma in Women: Probable Lack of Etiologic Association with Oral Contraceptive Steroids
Zachary D. Goodman, Kamal G. Ishak – 1 July 1982 – To investigate the possibility of an association between oral contraceptive steroids (CS) and hepatocellular carcinoma (HCC), we reviewed 128 cases of HCC in women collected between 1953 and 1980. There were 48 cases under the age of 40, and 13 of these (27%) had used CS. However, 62% of HCC associated with CS and 58% of HCC in women under 40 not using CS were classified histologically as “fibrolamellar” carcinoma. This subtype of HCC occurs predominantly in young people, both male and female.
Dane Particle‐Associated Hepatitis B e Antigen in Patients with Chronic Hepatitis B Virus Infection and Hepatitis B e Antibody
Giovanni Raimondo, Serafino Recchia, Carla Lavarini, Osvaldo Crivelli, Mario Rizzetto – 1 July 1982 – A commercial radioimmunoassay was adapted to detect serum Dane particle‐associated HBeAg in patients whose sera contained the homologous antibody. HBeAg was released from Dane particles with guanidine HC1.
Prothrombin and Vitamin K Revisited
Irwin M. Arias – 1 July 1982
Hepatitis A and Non‐A, Non‐B Viral Hepatitis in São Paulo, Brazil: Epidemiological, Clinical, and Laboratory Comparisons in Hospitalized Patients
Raymond S. Koff, Claudio S. Pannuti, Marcelo L. G. Pereira, Bengt G. Hansson, Jules L. Dienstag, V. Amato NETO, Doris C. Wong, Robert H. Purcell – 1 July 1982 – During a 33‐month period, 295 patients with acute viral hepatitis were admitted to a state hospital for civil servants and their dependents in Sao Paulo, Brazil. Seventy‐nine per cent (232) were HBsAg negative. To define the contribution of non‐A, non‐B viral hepatitis to hepatitis morbidity in this population, further serological studies were performed in 147 confirmed HBsAg‐negative patients.