Hepatocellular Carcinoma in Women: Probable Lack of Etiologic Association with Oral Contraceptive Steroids
Zachary D. Goodman, Kamal G. Ishak – 1 July 1982 – To investigate the possibility of an association between oral contraceptive steroids (CS) and hepatocellular carcinoma (HCC), we reviewed 128 cases of HCC in women collected between 1953 and 1980. There were 48 cases under the age of 40, and 13 of these (27%) had used CS. However, 62% of HCC associated with CS and 58% of HCC in women under 40 not using CS were classified histologically as “fibrolamellar” carcinoma. This subtype of HCC occurs predominantly in young people, both male and female.