Paul R. Harmatz, Ronald E. Kleinman, Bruce W. Bunnell, Kurt J. Bloch, W. Allan Walker – 1 May 1982 – The formation and clearance of circulating IgA immune complexes from blood to bile was investigated in this study. The i.v. injection of either MOPC‐315, an IgA M‐component with anti‐dinitrophenyl (DNP) specificity, or TEPC‐15, an IgA M‐component of a different specificity, was followed by i.v. injection of 125I‐DNP10‐bovine serum albumin (BSA) as the antigen.

James S. Dooley, Barry J. Potter, Howard C. Thomas, Sheila Sherlock – 1 May 1982 – In the rat, dimeric immunoglobulin A (dIgA) is cleared rapidly from the systemic circulation into bile by vesicular transport through the hepatocyte. Whether such transfer of dIgA occurs in man is controversial. The fate of dIgA and monomeric IgA (mIgA) was studied in rats with biliary drainage, and in parallel in 4 patients, 3 of whom had biliary drainage. Human dIgA and mIgA were prepared from myeloma sera and labeled with radioisotopes of iodine.

Christopher Pizzo, Donald Lee, Francis V. Chisari – 1 May 1982 – Isolated rat liver perfusates contain a substance which inhibits 3H‐thymidine uptake by phyto‐hemagglutinin‐stimulated human peripheral blood lymphocytes in a dose‐dependent, noncytotoxic fashion. Suppression is not due to interference of lymphocyte‐phytohemagglutinin interaction or dilution of the thymidine pool. Complete inhibition of thymidine uptake is achieved with less than 1.0 fig of material per ml (which is a potentially achievable concentration in vivo).

Catherine H. Wu, Marie‐Adele Giambrone, David J. Howard, Marcos Rojkind, George Y. Wu – 1 May 1982 – Livers from CF 1 mice infected with Schistosoma mansoni, 50 cercariae each, were examined 8 weeks postinfection. The collagen content of the livers was increased about 18‐fold over that for normal control animals. Quantitation of the collagen types in pepsin‐solubilized collagen showed a change in the ratio of Type I to Type III from 2:1 in normal mice to 1:1 in the fibrotic animals.

Stephan G. M. Meuwissen, Kurt P. Dingemans, Anneke Strijland, Joseph M. Tager, Bert C. M. Ooms – 1 March 1982 – Ultrastructural and biochemical analyses were made of liver biopsy material from a patient with longstanding Fabry's disease. Both hepatocytes as well as periportal macrophages showed lipid accumulations consisting of amorphous material as well as stacks of lamellar leaflets. Lipid inclusions in periportal macrophages were much larger than in hepatocytes. Furthermore, small round spheres were found exclusively in periportal macrophages.

Howard C. Thomas, David Brown, Guitaine Routhier, George Janossy, Patrick C. Kung, Gideon Goldstein, Sheila Sherlock – 1 March 1982 – During acute type B hepatitis, the proportion of inducer to cytotoxic/suppressor T‐cells is decreased due to an increase in the concentration of suppressor cells. Similar changes are seen in chronically infected subjects with evidence of active viral replication (HBeAg positive) and chronic hepatitis of varying severity.

Hyman J. Zimmerman – 1 March 1982

Roger D. Soloway, Eleanor B. Fayusal, Bruce W. Trotman, Norman E. Weston, James F. Ficca – 1 March 1982 – The water content of black pigment and cholesterol gallstones was evaluated with the use of moisture evolution analysis, electron spectroscopy for surface analysis, and X‐ray diffraction. X‐ray diffraction identified complex hydrated hydroxyapatite compounds in two stones. Moisture evolution analysis demonstrated that 18 pigment gallstones contained between 0.83 and 6.87% water; six cholesterol stones contained 0 to 0.27% (p < 0.001).

Frank D. Reilly, Ruth V. W. Dimlich, Eugene V. Cilento, Robert S. Mccuskey – 1 March 1982 – Several cholinergic agonists and their antagonists were administered topically at various concentrations (10−10 to 10−4 gm per ml) to the livers of anesthetized Sprague‐Dawley rats. Changes in the microvasculature were measured for a period of 15 min using in vivo microscopic methods. The influence of cholinergic agonists on hepatic mast cells was determined by histochemical methods.

Shizuko Takahashi, Michio Kobayashi – 1 March 1982 – Mice infected with Schistosoma mansoni develop hepatic fibrosis associated with enhanced collagen synthesis that out‐paces induced collagenase activity. Administration of one dose of concanavalin A [Con A (200 jug)] by i.p. injection to mice at 5 or 6 weeks after infection with 50 S. mansoni cercariae decreased liver collagen content by 50% compared to levels in control‐infected mice injected with either homologous immunoglobulin (200 jug) or phosphate‐buffered saline; additional doses of Con A had no further effect.