1 July 1982

Bernard Nordlinger, Michel Parquet, Recaredo Infante, Reginald Moreels, Pol Blondiau, Michele Boschat, Michèle Groussard, Claude Huguet – 1 July 1982 – All of the methods proposed for measuring portal blood flow are either invasive, estimate total rather than nutrient flow, and none has proved reliable in cirrhotic patients. A method has been derived from pharmacokinetic principles used for the calculation of bioavailability of drugs according to the route of administration (i.v. or p.o.) and tested experimentally in 20 pigs.

Douglas R. Labrecque, Frank A. Mitros, Radha J. Nathan, Ken G. Romanchuk, George F. Judisch, George H. El‐Khoury – 1 July 1982 – Arteriohepatic dysplasia (AHD) is a multisystem disorder which is characterized by liver, heart, eye, and bony abnormalities. A characteristic facies is also present. The etiology is not clear, and some authors have favored an in utero toxin or infection as the cause. Other reports have shown parent‐to‐child transmission suggesting an autosomal dominant form of inheritance.

Howard A. Liebman, Barbara C. Furie, Bruce Furie – 1 July 1982

John C. Hoefs, Hanna N. Canawati, Francisco L. Sapico, R. Randy Hopkins, John Weiner, John Z. Montgomerie – 1 July 1982 – Forty‐three patients with spontaneous bacterial peritonitis (SBP) between 1973 and 1978 were identified. Criteria for SBP included a positive ascites culture and polymorphonuclear cell concentration greater than 250 cells per mm3. Chronic liver disease was documented by varices in 91%, severe histologic fibrosis or cirrhosis in 94%, splenomegaly in 91%, and past hospitalization for liver disease in 57% of the patients.

Harold O. Conn – 1 July 1982

Dale A. Schoeller, Alfred L. Baker, Paul S. Monroe, Patricia S. Krager, John F. Schneider – 1 July 1982 – Different methods of expressing the results of the aminopyrine C02 breath test (ABT) were compared to determine the method that would be most sensitive for evaluating liver function.

Catherine H. Wu, Marie‐Adele Giambrone, David J. Howard, Marcos Rojkind, George Y. Wu – 1 May 1982 – Livers from CF 1 mice infected with Schistosoma mansoni, 50 cercariae each, were examined 8 weeks postinfection. The collagen content of the livers was increased about 18‐fold over that for normal control animals. Quantitation of the collagen types in pepsin‐solubilized collagen showed a change in the ratio of Type I to Type III from 2:1 in normal mice to 1:1 in the fibrotic animals.

Christopher Pizzo, Donald Lee, Francis V. Chisari – 1 May 1982 – Isolated rat liver perfusates contain a substance which inhibits 3H‐thymidine uptake by phyto‐hemagglutinin‐stimulated human peripheral blood lymphocytes in a dose‐dependent, noncytotoxic fashion. Suppression is not due to interference of lymphocyte‐phytohemagglutinin interaction or dilution of the thymidine pool. Complete inhibition of thymidine uptake is achieved with less than 1.0 fig of material per ml (which is a potentially achievable concentration in vivo).

James S. Dooley, Barry J. Potter, Howard C. Thomas, Sheila Sherlock – 1 May 1982 – In the rat, dimeric immunoglobulin A (dIgA) is cleared rapidly from the systemic circulation into bile by vesicular transport through the hepatocyte. Whether such transfer of dIgA occurs in man is controversial. The fate of dIgA and monomeric IgA (mIgA) was studied in rats with biliary drainage, and in parallel in 4 patients, 3 of whom had biliary drainage. Human dIgA and mIgA were prepared from myeloma sera and labeled with radioisotopes of iodine.