Harold O. Conn – 1 July 1982

Dale A. Schoeller, Alfred L. Baker, Paul S. Monroe, Patricia S. Krager, John F. Schneider – 1 July 1982 – Different methods of expressing the results of the aminopyrine C02 breath test (ABT) were compared to determine the method that would be most sensitive for evaluating liver function.

Catherine H. Wu, Marie‐Adele Giambrone, David J. Howard, Marcos Rojkind, George Y. Wu – 1 May 1982 – Livers from CF 1 mice infected with Schistosoma mansoni, 50 cercariae each, were examined 8 weeks postinfection. The collagen content of the livers was increased about 18‐fold over that for normal control animals. Quantitation of the collagen types in pepsin‐solubilized collagen showed a change in the ratio of Type I to Type III from 2:1 in normal mice to 1:1 in the fibrotic animals.

Christopher Pizzo, Donald Lee, Francis V. Chisari – 1 May 1982 – Isolated rat liver perfusates contain a substance which inhibits 3H‐thymidine uptake by phyto‐hemagglutinin‐stimulated human peripheral blood lymphocytes in a dose‐dependent, noncytotoxic fashion. Suppression is not due to interference of lymphocyte‐phytohemagglutinin interaction or dilution of the thymidine pool. Complete inhibition of thymidine uptake is achieved with less than 1.0 fig of material per ml (which is a potentially achievable concentration in vivo).

James S. Dooley, Barry J. Potter, Howard C. Thomas, Sheila Sherlock – 1 May 1982 – In the rat, dimeric immunoglobulin A (dIgA) is cleared rapidly from the systemic circulation into bile by vesicular transport through the hepatocyte. Whether such transfer of dIgA occurs in man is controversial. The fate of dIgA and monomeric IgA (mIgA) was studied in rats with biliary drainage, and in parallel in 4 patients, 3 of whom had biliary drainage. Human dIgA and mIgA were prepared from myeloma sera and labeled with radioisotopes of iodine.

Paul R. Harmatz, Ronald E. Kleinman, Bruce W. Bunnell, Kurt J. Bloch, W. Allan Walker – 1 May 1982 – The formation and clearance of circulating IgA immune complexes from blood to bile was investigated in this study. The i.v. injection of either MOPC‐315, an IgA M‐component with anti‐dinitrophenyl (DNP) specificity, or TEPC‐15, an IgA M‐component of a different specificity, was followed by i.v. injection of 125I‐DNP10‐bovine serum albumin (BSA) as the antigen.

John M. Vierling, Paul D. Berk, Alan F. Hofmann, James F. Martin, Allan W. Wolkoff, Bruce F. Scharschmidt – 1 May 1982 – Fasting levels of cholic acid conjugates were determined by radioimmunoassay in the serum of 24 patients with extensively documented Gilbert's syndrome and in 98 healthy controls without unconjugated hyperbilirubinemia. The Gilbert's syndrome patients studied included all three subtypes, as determined from studies of the plasma disappearance kinetics of sulf obromophthalein and indocyanine green.

Ruth V. W. Dimlich, Samuel F. Townsend, Frank D. Reilly – 1 May 1982 – Blood glucose, hepatic glycogen, and mean carotid blood pressure were determined in anesthetized Sprague‐Dawley rats receiving an i.v. infusion of Compound 48/80, pilocarpine, or Ringer's solution as a control. Histochemical determinations of the integrity and number of hepatic mast cells and hepatic glycogen content also were performed at the light microscopic level, and the results compared to those from rats whose livers were treated topically with each of these compounds.

Charles S. Davidson, Samuel W. French – 1 May 1982

Helmer Ring‐Larsen, Birger Hesse, Jens H. Henriksen, Niels J. Christensen – 1 May 1982 – Systemic and renal neurovascular reactivity was investigated in eight patients with cirrhosis and in eight control subjects with fatty liver during postural changes. In the supine position, mean renal blood flow averaged 1.51 and 2.97 ml per gm per min in patients and controls, respectively (p < 0.02).