Hans Popper – 1 January 1983

Maria Anna Leo, Charles S. Lieber – 1 January 1983 – Rats were fed up to 9 months diets supplemented with vitamin A in an amount that, by itself, had no apparent adverse effect on the liver. When associated with chronic ethanol administration, vitamin A supplementation strikingly exacerbated ethanol‐induced abnormalities: fat accumulation was increased and numerous giant mitochondria were observed. Furthermore, lesions appeared which ethanol alone does not produce in rats, namely necrosis, inflammation, and fibrosis.

Daniel Mirouze, Robert D. Zipser, Telfer B. Reynolds – 1 January 1983 – The effect of inhibitors of prostaglandin synthesis on diuretic action was examined in patients with ascites due to chronic liver disease and in normal subjects. In patients with ascites, natriuresis after 80 mg i.v. furosemide was reduced 82% by pretreatment with indomethacin. Creatinine clearance was reduced only 16%. These effects were likely due to inhibition of renal prostaglandin synthesis, since urinary prostaglandin E2 fell and there was also reduction in natriuresis with naproxen (52%).

Earl F. Meierhenry, Boris H. Ruebner, M. Eric Gershwin, Lucy S. Hsieh, Samuel W. French – 1 January 1983 – Mallory bodies (MBs) were induced in hepatic tumors by administration for up to 85 weeks of a diet containing 10 ppm dieldrin to 50 C3H/He and 62 C57BL/6J X C3H/He B6C3F1 male mice. MBs were seen in 15 of 28 (54%) mice which developed benign hepatic tumors and 33 of 45 (73%) mice with hepatocellular carcinoma, but in only 3 of 39 (8%) mice without hepatic tumors.

Ruy Perez Tamayo – 1 January 1983

Harold O. Conn – 1 January 1983

Peter G. Mavrelis, Helmut V. Ammon, John J. Gleysteen, Richard A. Komorowski, Ursula K. Charaf – 1 January 1983 – Alcoholic liver disease is characterized by the accumulation of fat and inflammatory changes in the liver. Because free fatty acids, the precursors of triglycerides, can damage biological membranes, accumulation of free fatty acids in the liver might be in part responsible for the functional and morphological changes seen in alcoholic liver disease.

Roberto J. Groszmann, David Kravetz, Jaime Bosch, Mortom Glickman, Jordi Bruix, James Bredfeldt, Harold O. Conn, Juan Rodes, Edward H. Storer – 1 November 1982 – This study was designed to investigate whether the addition of nitroglycerin to vasopressin infusion could avoid the deleterious systemic effects of vasopressin while maintaining or enhancing the therapeutic benefits of portal pressure reduction. The effect of nitroglycerin on splanchnic and systemic hemodynamics was studied in cirrhotic patients and portal hypertensive dogs receiving i.v. vasopressin. During i.v.

M. James Phillips, Chikara Oshio, Mamoru Miyairi, Hart Katz, Charles R. Smith – 1 November 1982 – Living hepatocytes observed under standard methods of cell isolation and culture show frequent active contractions of bile canaliculi when viewed by time‐lapse cinephotomicrography. This report gives details of the methods used to show the contractions. In addition, the characteristics of the contraction pattern are defined and analyzed. The contractions are regular, canalicular contraction time (systole) lasts 60 sec, and the most probable interval between contractions is 5 1/2 min.

Kunihiko Ohnishi, Akihiko Mishima, Kunio Okuda – 1 November 1982 – The localization of the form of cytochrome P‐450 that is induced by phenobarbital was studied by direct immunofluorescence in the hepatocytes of rats pretreated with phenobarbital in comparison with saline‐treated rats. Specific fluorescence was seen in the hepatocyte cytoplasm in saline‐ and phenobarbital‐treated rats; a more concentrated halo of fluorescence was detected surrounding the nuclei in the centrilobular zones after phenobarbital treatment.