Are Nuclear Particles Specific for Non‐A, Non‐B Hepatitis?

Rita De Vos, Marie J. Vanstapel, Jan Desmyter, Chris De Wolf‐Peeters, Guy De Groote, Jan Colaert, Jan Mortelmans, Jan De Groote, Johan Fevery, Valeer Desmet – 1 January 1983 – This study reports the findings of an electron microscopic search for so‐called non‐A, non‐B nuclear particles in liver biopsies from patients with mainly chronic or prolonged liver disease and from chimpanzees.

Hypouricemia and Hyperuricosuria as Expressions of Renal Tubular Damage in Primary Biliary Cirrhosis

Namiki Izumi, Yasushi Hasumura, Jugoro Takeuchi – 1 January 1983 – Renal tubular damage, in particular, renal tubular acidosis is associated with primary biliary cirrhosis (PBC), but hypouricemia has not been described. We studied four patients with PBC whose serum uric acid levels were 1.4 to 1.8 mg per dl, and compared their renal and liver functions with those of 11 patients with PBC whose serum uric acid levels were normal. In the patients with PBC and hypouricemia, uric acid clearance (Cua) and the ratio of Cua and creatinine clearance (Cua/Ccr) were high enough to cause hypouricemia.

Hepatic Fibrosis After Long‐Term Administration of Ethanol and Moderate Vitamin A Supplementation in the Rat

Maria Anna Leo, Charles S. Lieber – 1 January 1983 – Rats were fed up to 9 months diets supplemented with vitamin A in an amount that, by itself, had no apparent adverse effect on the liver. When associated with chronic ethanol administration, vitamin A supplementation strikingly exacerbated ethanol‐induced abnormalities: fat accumulation was increased and numerous giant mitochondria were observed. Furthermore, lesions appeared which ethanol alone does not produce in rats, namely necrosis, inflammation, and fibrosis.

Effect of Inhibitors of Prostaglandin Synthesis On Induced Diuresis in Cirrhosis

Daniel Mirouze, Robert D. Zipser, Telfer B. Reynolds – 1 January 1983 – The effect of inhibitors of prostaglandin synthesis on diuretic action was examined in patients with ascites due to chronic liver disease and in normal subjects. In patients with ascites, natriuresis after 80 mg i.v. furosemide was reduced 82% by pretreatment with indomethacin. Creatinine clearance was reduced only 16%. These effects were likely due to inhibition of renal prostaglandin synthesis, since urinary prostaglandin E2 fell and there was also reduction in natriuresis with naproxen (52%).

Dieldrin‐Induced Mallory Bodies in Hepatic Tumors of Mice of Different Strains

Earl F. Meierhenry, Boris H. Ruebner, M. Eric Gershwin, Lucy S. Hsieh, Samuel W. French – 1 January 1983 – Mallory bodies (MBs) were induced in hepatic tumors by administration for up to 85 weeks of a diet containing 10 ppm dieldrin to 50 C3H/He and 62 C57BL/6J X C3H/He B6C3F1 male mice. MBs were seen in 15 of 28 (54%) mice which developed benign hepatic tumors and 33 of 45 (73%) mice with hepatocellular carcinoma, but in only 3 of 39 (8%) mice without hepatic tumors.

Hepatic Free Fatty Acids in Alcoholic Liver Disease and Morbid Obesity

Peter G. Mavrelis, Helmut V. Ammon, John J. Gleysteen, Richard A. Komorowski, Ursula K. Charaf – 1 January 1983 – Alcoholic liver disease is characterized by the accumulation of fat and inflammatory changes in the liver. Because free fatty acids, the precursors of triglycerides, can damage biological membranes, accumulation of free fatty acids in the liver might be in part responsible for the functional and morphological changes seen in alcoholic liver disease.

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