Johan Fevery, Norbert Blanckaert, Pol Leroy, Roger Michiels, Karel P. M. Heirwegh – 1 January 1983 – A method was developed to extract quantitatively the bilirubins from bile, urine, serum, stool, and preparations from liver with a chloroform‐ethanol mixture at pH 1.8 in the presence of ascorbic acid and NaCl.

Giulio Marchesini, Gabriele Forlani, Marco Zoli, Cristina Dondi, Glampaolo Blanchi, Vlncenzo Bua, Pletro Vannini, Emilio Plsi – 1 January 1983 – To test the hypothesis that hyperinsulinism is responsible for reduced branched‐chain amino acids in cirrhotics, plasma amino acids were sequentially determined in 8 controls and 8 matched cirrhotics during continuous i.v. insulin infusion. An artificial endocrine pancreas which infused glucose was used to sustain euglycemia. Basal plasma insulin levels were high and branched‐chain amino acids were reduced in cirrhotics.

Alan F. Hofmann, Paul A. Kantrowitz – 1 January 1983

J. Thomas Lamont, Allen S. Ventola, Bruce W. Trotman, Roger D. Soloway – 1 January 1983 – Mucin glycoproteins, a secretory product of the gallbladder, are thought to contribute to the matrix or nucleus of gallstones. Human black pigment stones originate in the gallbladder and have as their major constituent calcium bilirubinate, as well as inorganic salts and small amounts of cholesterol. The object of this study was to estimate the amount of glycoprotein in black pigment stones and to isolate gallbladder mucin from dissolved stones.

Peter Ferenci, David Covell, Daniel F. Schafer, Jeanne G. Waggoner, Richard Shrager, E. Anthony Jones – 1 January 1983 – The serum concentration of 7‐aminobutyric acid (GABA) has been found to be elevated by more than an order of magnitude in a rabbit model of acute hepatic failure. A potential mechanism for increased serum GABA levels in liver failure is decreased catabolism of GABA.

Giovambattista, Rosa Giovanna Simonetti, Antonio Craxí, Sonia Di Piazza, Caterina Spanó, Luigi Pagliaro – 1 January 1983 – Two hundred and twenty‐four consecutive inpatients with cirrhosis, mostly of nonalcoholic etiology, and ascites were prospectively investigated on admission for spontaneous bacterial peritonitis (SBP) by culture, smear, and polymorphonuclear (PMN) counts of ascitic fluid. Positive cultures were found in 54 patients. A possible intraabdominal source of infection was apparent in five of them, all with clinically overt peritonitis (secondary peritonitis).

1 January 1983

Kenichi Kobayashi, Kenichi Fukuoka, Fumiaki Matsushita, Hideo Morimoto, Yoshinobu Hinoue, Hideo Honjo, Nobuyoshi Tanaka, Tatsuho Sugimoto, Yasuhiro Kato, Nobu Hattori, Shigeharu Ueda, Shiro Kato – 1 January 1983 – Woodchuck hepatocellular carcinoma has been successfully transplanted into nude (athymic) mice. The morphology of heterotransplanted tumor is similar to that of naturally occurring hepatocellular carcinoma before transplantation. The growth rate of transplanted tumor was very slow compared with those of other transplanted tumors. During the first month, only two tumors appeared.

Clifford J. Steer, Doris A. Wall, Gilbert Ashwell – 1 January 1983 – Coated vesicles were isolated from rat liver by a modification of the procedure described by Nandi et al. for bovine brain (Proc. Natl. Acad. Sci. U.S.A. 1982; 79:5881–5885). The hepatic receptor for asialoglycoproteins was shown to be an integral constitutent of these vesicles as evidenced by their ability to bind 125I‐asialo‐orosomucoid in a specific and saturable manner.

Thomas S. Edgington – 1 January 1983