Hepatorenal Disorders. By S. P. Wilkinson. viii + 196 pp. New York: Marcel Dekker, 1982. $32.75.
Norman G. Levinsky – 1 January 1983
Cimetidine Does Not Reduce Liver Blood Flow in Cirrhosis
J. Michael Henderson, Shakir Z. Ibrahim, William J. Millikan, Michael Santi, W. Dean Warren – 1 January 1983 – Cimetidine has been shown to reduce liver blood flow, as measured by indocyanine green clearance, in normal subjects. Concern over the potential deleterious effects of such reduction in cirrhosis led to the measurement of blood flow in 14 cirrhotics receiving oral or intravenous cimetidine. Liver blood flow was measured by the clearance of galactose at steady state during infusion of 40 mg per min.
Chemoprotective Effects of Two Dithiolthiones and of Butylhydroxyanisole Against Carbon Tetrachloride and Acetaminophen Toxicity
Sherry S. Ansher, Patrick Dolan, Ernest Bueding – 1 January 1983 – Administration of tert‐butyl‐4‐hydroxyanisole or of two dithiolthiones to female CD‐I mice protected against the acute toxic effects of two hepatotoxic agents, acetaminophen and carbon tetrachloride. Reduced mortality of mice was observed following pretreatment with tert‐butyl‐4‐hydroxyanisole or dithiolthiones. Pretreatment reduced or prevented hepatic glutathione depletion produced by these two hepatotoxic agents.
Randomized Controlled Trial of Quinacrine for the Treatment of HBsAg‐Positive Chronic Hepatitis
Henry C. Bodenheimer, Fenton Schaffner, Salvatore Vernace, Shalom Z. Hirschman, Judith D. Goldberg, Thomas Chalmers – 1 January 1983 – Several drugs which react with DNA decrease hepatitis B viral (HBV) DNA polymerase activity in vitro. Because such an alteration of viral replication, if produced in patients with hepatitis B surface antigen (HBsAg)‐positive chronic hepatitis, may lead to elimination of viral infection, we conducted a controlled trial of the use of the intercalating agent, quinacrine hydrochloride, in treatment of HBsAg‐positive chronic hepatitis.
Oncogene Expression in Liver Regeneration and Hepatocarcinogenesis
Nelson Fausto, Peter R. Shank – 1 January 1983
Murine Hepatitis Induced by Frog Virus 3: A Model for Studying the Effect of Sinusoidal Cell Damage on the Liver
André Kirn, Jean‐Pierre Gut, Annick Bingen, Anne‐Marie Steffan – 1 January 1983
Analysis of Bilirubins in Biological Fluids by Extraction and Thin‐Layer Chromatography of the Intact Tetrapyrroles: Application to Bile of Patients with Gilbert's Syndrome, Hemolysis, or Cholelithiasis
Johan Fevery, Norbert Blanckaert, Pol Leroy, Roger Michiels, Karel P. M. Heirwegh – 1 January 1983 – A method was developed to extract quantitatively the bilirubins from bile, urine, serum, stool, and preparations from liver with a chloroform‐ethanol mixture at pH 1.8 in the presence of ascorbic acid and NaCl.