Makoto Hashizume, Kenzo Tanaka, Kiyoshi Inokuchi – 1 January 1983 – Morphologic alterations in the gastric microcirculation in cirrhosis were investigated following infusion of a silicone rubber compound into vessels of the excised stomach which was then cleared with methyl salicylate. In cirrhosis, arteriovenous anastomoses 15 to 50 jum in diameter were present in 5 of 10 patients; spiral arterioles were less than one‐tenth as numerous as in stomachs from noncirrhotic patients.

Jaime Bosch, Rosa Enriquez, Roberto J. Groszmann, Edward H. Storer – 1 January 1983 – Splanchnic and systemic hemodynamics were measured in six normal dogs and in 18 dogs that had the bile ducts ligated for a period of 8 weeks. In the bile duct‐ligated dogs, there was a decrease in arterial pressure (110 ± 4 mm Hg vs. normal 136 ± 6 mm Hg; p < 0.005) and peripheral vascular resistance (4.60 ± 0.38 vs. 6.28 ± 0.38 dynes‐sec‐cm−5; p < 0.02), and an increase in cardiac index (129 ± 7 vs. 98 ± 9 ml per min per kg; p < 0.05).

Gabriele E. Schrempf‐Decker, Diethard P. Baron, Norbert W. Brattig, Hermann Bockhorn, Peter A. Berg – 1 January 1983 – The liver immunoregulatory protein (LIP) was originally characterized as human liver‐derived soluble factor which inhibited the alloantigen and phytohemagglutinin‐induced proliferation of human lymphocytes (1). Soluble extracts prepared under the same experimental conditions from kidney, spleen, heart, lymph nodes, and erythrocytes did not exert any inhibitory activity (2). The purpose of this study was to characterize the immunobiological properties of LIP.

John E. Hegarty, Kayhan T. Nouri Aria, Bernard Portmann, Adrian L. W. F. Eddleston, Roger Williams – 1 January 1983 – A prospective study was performed to evaluate the outcome of treatment withdrawal in 30 patients with “autoimmune” chronic active hepatitis in remission for periods of 1.5 to 9 years on maintenance corticosteroid and azathioprine therapy. Reactivation of disease, with marked rises in serum aminotransferase level (mean 668 ± S.D.

William V. Mcdermott – 1 January 1983

Clyde Crumpacker – 1 January 1983

Sten Eriksson, Christer Larsson – 1 January 1983 – Three of four adult siblings in a family which was studied for three generations had clinical and/ or laboratory signs of slowly progressive intrahepatic cholestasis. Slight hyper pigmentation, facial hypertrichosis, and hypothyroidism were seen in affected individuals who also had prolonged increase in serum transaminase, γ‐glutamyltranspeptidase, and alkaline phosphatase activities.

William G. M. Hardison, Robin G. Weiner, David E. Hatoff, Katsumi Miyai – 1 January 1983 – Biliary obstruction in the rat causes known biochemical and morphological abnormalities. These abnormalities might be caused simply by retention of biliary constituents or might require other factors such as high biliary pressure, interruption of the normal flux of fluid, ions, and other biliary constituents through the hepatocyte and/or changes in intracellular concentrations, binding, and distribution of biliary constituents.

Gary C. Kanel, George Radvanand, Robert L. Peters – 1 January 1983 – To establish whether there is any significant relationship between high‐density lipoprotein cholesterol (HDLC) concentrations and biopsy‐documented liver disease, 169 patients had needle biopsies, serum cholesterol, and HDLC evaluated. Twenty‐four patients had serial cholesterol, HDLC, prothrombin, and aminotransferase levels and activities examined. In both men and women, HDLC decreased strikingly and significantly in acute alcoholic hepatitis and in acute viral hepatitis, compared to controls (p < 0.001).

Geoffrey Dusheiko, Ernest Song, Sheila Bowyer, Michael Whitcutt, Gunthild Maier, Anthony Meyers, Mlchael C. Kew – 1 January 1983 – Hepatitis B virus (HBV) markers were measured in 83 immunosuppressed renal transplant patients who were followed for periods of 2 to 15 years. Sixty‐nine patients were negative for HBsAg before transplantation, of whom 14 were positive for anti‐HBs. The remaining 14 patients were HBsAg positive prior to transplantation. Eighteen patients were identified as being HBsAg positive during the follow‐up period.