J. Michael Henderson, Shakir Z. Ibrahim, William J. Millikan, Michael Santi, W. Dean Warren – 1 January 1983 – Cimetidine has been shown to reduce liver blood flow, as measured by indocyanine green clearance, in normal subjects. Concern over the potential deleterious effects of such reduction in cirrhosis led to the measurement of blood flow in 14 cirrhotics receiving oral or intravenous cimetidine. Liver blood flow was measured by the clearance of galactose at steady state during infusion of 40 mg per min.

Sherry S. Ansher, Patrick Dolan, Ernest Bueding – 1 January 1983 – Administration of tert‐butyl‐4‐hydroxyanisole or of two dithiolthiones to female CD‐I mice protected against the acute toxic effects of two hepatotoxic agents, acetaminophen and carbon tetrachloride. Reduced mortality of mice was observed following pretreatment with tert‐butyl‐4‐hydroxyanisole or dithiolthiones. Pretreatment reduced or prevented hepatic glutathione depletion produced by these two hepatotoxic agents.

Henry C. Bodenheimer, Fenton Schaffner, Salvatore Vernace, Shalom Z. Hirschman, Judith D. Goldberg, Thomas Chalmers – 1 January 1983 – Several drugs which react with DNA decrease hepatitis B viral (HBV) DNA polymerase activity in vitro. Because such an alteration of viral replication, if produced in patients with hepatitis B surface antigen (HBsAg)‐positive chronic hepatitis, may lead to elimination of viral infection, we conducted a controlled trial of the use of the intercalating agent, quinacrine hydrochloride, in treatment of HBsAg‐positive chronic hepatitis.

Nelson Fausto, Peter R. Shank – 1 January 1983

Michael D. Kaye – 1 January 1983

André Kirn, Jean‐Pierre Gut, Annick Bingen, Anne‐Marie Steffan – 1 January 1983

Karl Sorger – 1 January 1983

Johan Fevery, Norbert Blanckaert, Pol Leroy, Roger Michiels, Karel P. M. Heirwegh – 1 January 1983 – A method was developed to extract quantitatively the bilirubins from bile, urine, serum, stool, and preparations from liver with a chloroform‐ethanol mixture at pH 1.8 in the presence of ascorbic acid and NaCl.

Giulio Marchesini, Gabriele Forlani, Marco Zoli, Cristina Dondi, Glampaolo Blanchi, Vlncenzo Bua, Pletro Vannini, Emilio Plsi – 1 January 1983 – To test the hypothesis that hyperinsulinism is responsible for reduced branched‐chain amino acids in cirrhotics, plasma amino acids were sequentially determined in 8 controls and 8 matched cirrhotics during continuous i.v. insulin infusion. An artificial endocrine pancreas which infused glucose was used to sustain euglycemia. Basal plasma insulin levels were high and branched‐chain amino acids were reduced in cirrhotics.

Alan F. Hofmann, Paul A. Kantrowitz – 1 January 1983