Jay H. Lefkowitch, Kuo‐Ching Feng‐Chen, Jeffrey A. Sklar, Maureen B. Poh‐Fitzpatrick – 1 January 1983 – We studied the effects of cholic acid treatment on hepatic histology and ultrastructure in mice with griseofulvin‐induced protoporphyria. After 5 weeks of feeding griseofulvin alone, control mice developed darkly pigmented livers which by light microscopy showed birefringent, brown pigment deposits in bile ducts and ductules, sinusoidal Kupffer cell aggregates, and occasionally in hepatocytes and bile canaliculi.

Felix Witassek, Johannes Bircher, Philipp Huguenin, Rudolf Preisig – 1 January 1983 – The disposition of zomepirac was investigated in 18 patients with various liver diseases and in 10 healthy normal subjects in order to further test the hypothesis that glucuronidation of drugs may be spared in liver disease. Severity of the liver disease was assessed by the galactose elimination capacity. Following oral administration of zomepirac (200 mg), plasma and urinary drug concentrations were measured by high‐pressure liquid chromatography. Urine was assayed before and after alkaline hydrolysis.

Elie S. Zafrani, Bernard Leclercq, Jean‐Paul Vernant, Yvon Pinaudeau, Guy Chomette, Daniel Dhumeaux – 1 January 1983 – The clinical and pathological findings in four cases of fulminant hepatic failure due to massive infiltration of the liver by acute leukemia or lymphoma are reported. Liver abnormalities were found simultaneously with or led to the discovery of hematologic malignancies, and consisted of marked hepatomegaly and severe hepatocellular insufficiency associated with hyperlactatemia. The blood malignancies were peculiar in their fast cellular growth and large tumor mass.

Clifford J. Steer, Richard D. Klausner – 1 January 1983

Sheila Sherlock, Howard C. THomas – 1 January 1983 – Assays for the detection of nucleic acid in serum are likely to be better systems for determining infectivity than indirect ones dependent on detection of virus‐encoded proteins such as HBeAg. The hybridization assays are particularly useful in monitoring spontaneous or treatment‐related conversion from the “replicative” to “nonreplicative” phase of HB V infection.

John Wahren, Jacques Denis, Philippe Desurmont, Ljusk S. Eriksson, Jean‐Marc Escoffier, André P. Gauthier, Lars Hagenfeldt, Henri Michel, Pierre Opolon, Jean‐Claude Paris, Michel Veyrac – 1 January 1983 – The influence of intravenous infusion of branched‐chain amino acids (BCAAs) on brain function in patients with liver cirrhosis and acute hepatic encephalopathy was examined using a double‐blind, randomized study design. Five medical centers in France and Sweden participated, and 50 patients were studied.

John A. Balint – 1 January 1983

Gary Gitnick, Steven Weiss, Lacy R. Overby, Chung‐Mei Ling, Ruben Chairez, Khosrow Parsa – 1 January 1983 – An outbreak of non‐A, non‐B hepatitis (NANBH) in a hemodialysis unit was prospectively studied and the clinical, biochemical, and serologic events were correlated with an experimental immunodiffusion assay for serum antigen and antibody. One hundred sixteen subjects (76 dialysis patients and 40 staff members) were studied over an 8‐month period.

Alex W. Marshall, David Kingstone, Margot Boss, Marsha Y. Morgan – 1 January 1983 – Ethanol pharmacokinetics were determined following oral ethanol, 0.5 gm per kg, in nine normal women and 10 normal men, and related to total body water measured by 3H‐water dilution and body fat determined anthropometrically. Ethanol pharmacokinetics were similar in the females throughout the menstrual cycle. No variation was seen in mean peak blood ethanol concentration or elimination rate in the midfollicular (Days 8 to 10) and midluteal (Days 22 to 24) phases.

Harold O. Conn – 1 January 1983