Ultrastructural Evidence of Intrahepatic Cholestasis Before and After Chenodeoxycholic Acid Therapy in Patients with Cholelithiasis: The National Cooperative Gallstone Study
M. James Phillips, Rosemarie L. Fisher, Deborah W. Anderson, Shu‐Ping Lan, John M. Lachin, James L. Boyer, The Steering Committee for the National Cooperative Gallstone Study Group – 1 January 1983 – Electron microscopy was performed to assess potential hepatotoxicity before and after 9 and 24 months of chenodeoxycholic acid (CDCA) therapy (375 or 750 mg, daily) in 103 patients with cholelithiasis.