R. Palmer Beasley, Lu‐Yu Hwang, Cladd E. Stevens, Chia‐Chin Lin, Fon‐Jou Hsieh, Kwei‐Yu Wang, Tsu‐Shen Sun, Wolf Szmuness – 1 January 1983 – A randomized double‐blind, placebo‐controlled efficacy trial of hepatitis B immune globulin (HBIG) for prevention of the mother‐to‐infant transmitted HBsAg carrier state was conducted in Taiwan where the carrier rate in the general population is 15 to 20%. HBIG was given immediately after birth to infants of e antigen positive HBsAg carrier mothers, and all infants were followed for at least 15 months.

J.Thomas LaMont, Bradley S. Turner, Seldon E. Bernstein, Bruce W. Trotman – 1 January 1983 – The nb/nb mouse with hereditary hemolytic anemia provides an animal model for the study of pigment gallstone disease. We measured glycoprotein synthesis and secretion in gallbladder neck and fundus of 6‐month‐old mice without stones, and in 12‐month‐old mice with and without stones in order to determine the effect of age and presence or absence of stones on mucin release.

Sarah Shefer, F. George Zaki, Gerald Salen – 1 January 1983 – The effect of high doses of chenodeoxycholic and ursodeoxycholic acids on hepatic morphology and on cholesterol and hile acid metabolism was examined in the rat. After 2 weeks of either cheno or ursodeoxycholic acid feeding, the livers of the treated rats revealed marked proliferation of the smooth endoplasmic reticulum which appeared as an adaptation phenomenon of the microsomal enzyme system in response to bile acid intake.

H. G. Weed – 1 January 1983

Michel Odièvre, Giuseppe Maggiore, Jean‐Claude Homberg, Fabrice Saadoun, Anne‐Marié Courouce, Jeannine Yvart, Michelle Hadchouel, Daniel Alagille – 1 January 1983 – A seroimmunologic evaluation of 57 children with chronic hepatitis is presented. Twenty‐one patients had chronic persistent hepatitis and 36 had chronic active hepatitis. Serum samples obtained before treatment were tested for HBsAg, anti‐HBs, anti‐HBc, smooth muscle antibody, and antibody to endoplasmic reticulum.

Daniel P. Rosenberg, Rachel Morecki, Lance O. Lollini, Joy Glaser, Charles E. Cornelius – 1 January 1983 – Extrahepatic biliary atresia was observed in a 6‐week‐old female rhesus monkey. Jaundice and conjugated hyperbilirubinemia were detected at the age of 6 days and persisted throughout life. At 6 weeks of age, the diagnosis of extrahepatic biliary atresia was established at exploratory laparotomy, and bile duct remnants were biopsied.

James L. Boyer – 1 January 1983

Merrill C. Johnson – 1 January 1983

Norbert W. Brattig, Peter A. Berg – 1 January 1983 – Sera from patients with acute viral hepatitis B were found to inhibit the in vitro proliferation of normal lymphocytes induced by different mitogens and antigens. In addition, an effect on concanavalin A‐induced T suppressor cell activity and pokeweed mitogen‐stimulated IgG and IgM synthesis was demonstrated.

Norbert W. Brattig, Gabriele E. Schrempf‐Decker, Christoph W. Brockl, Peter A. Berg – 1 January 1983 – Immunosuppressive factor(s) in sera from patients with acute viral hepatitis B [serum inhibition factor(s) (SIF)] which functioned like an antiactivator of lymphocytes were further characterized and purified. The active moiety could be separated from immunoglobulins and other serum proteins by means of gel filtration, anion exchange, and affinity chromatography. The major SIF activity always copurified with albumin.