Splanchnic and Hepatic Metabolism of Somatostatin: A Study in Cirrhotic Patients with a Portacaval Shunt

Susan Webb, David Kravetz, Jaume Bosch, John A. H. Wass, Joan Evans, Ramon Gomis, Lesley H. Rees, Joan Rodes – 1 January 1983 – Experimental data suggest that somatostatin is metabolized by both liver and kidneys. Results in humans are conflicting. By studying a group of cirrhotic patients with surgically induced end‐to‐side portacaval shunts, basally and during a somatostatin infusion, we have been able to analyze separately the hepatic and splanchnic metabolism of this peptide. After catheterization, samples were obtained from the pulmonary artery, portal and hepatic veins.

Glutathione S‐Transferase in Human Hepatocellular Carcinoma

Morris Sherman, John A. H. Campbell, Sally A. Titmuss, Michael C. Kew, Ralph E. Kirsch – 1 January 1983 – Qualitative and quantitative changes in glutathione S‐transferase (GSH‐T) were studied in human hepatocellular carcinoma. GSH‐T specific activity (/imoles per min per mg protein) was variably reduced in hepatocellular carcinoma. Similar changes were seen in “cationic” GSH‐T (ligandin) concentration determined by radioimmunoassay. Immunohistochemical studies with antihuman liver ligandin suggest that positive staining was more frequently found in well‐differentiated tumors.

Decreased Albumin and Increased Fibrinogen Secretion by Single Hepatocytes from Rats with Acute Inflammatory Reaction

Dominique Bernuau, Edith Rogier, Gérard Feldmann – 1 January 1983 – During the acute inflammatory reaction (AIR), the plasma concentration of several plasma proteins, including fibrinogen, is increased as a result of enhanced production by the liver. Whether this increased production influences the production of the other plasma proteins at the single hepatocyte level is not known.

Mallory Body Formation Runs Parallel to γ‐Glutamyl Transferase Induction in Hepatocytes of Griseofulvin‐Fed Mice

Junichi Tazawa, Tetsuya Irie, Samuel W. French – 1 January 1983 – To evaluate whether Mallory bodies (MBs) are linked to the induction of the enzyme γ‐glutamyl transferase (GGT), mice were fed 2.5% griseofulvin (GF). The experimental and control mice livers were examined at four time periods, i.e., after 4 months' of GF feeding, 1 month after GF withdrawal and 13 days after GF refeeding, and at sacrifice after 4 months of GF withdrawal. The livers from mice continuously fed GF or control diet for 10 months were also examined.

The Liver in the IgA Secretory Immune System. Dogs, But Not Rats and Rabbits, Are Suitable Models for Human Studies

Dominique L. Delacroix, Gildo Furtado‐Barreira, Bernard De Hemptinne, Jan Goudswaard, Charles Dive, Jean‐Pierre Vaerman – 1 January 1983 – The liver transport of polymeric IgA (plgA) from plasma into bile and the immunohistochemical distribution of secretory component (SC) in the liver were studied in dogs, and compared to those in humans, rats, and rabbits.

Immunoregulatory T Cell Subsets in Chronic Hepatitis B Virus Infection: The Influence of Homosexuality

Fredric G. Regenstein, Stanford T. Roodman, Robert P. Perrillo – 1 January 1983 – The purposes of this study were 2‐fold: (i) To enumerate peripheral immunoregulatory T cell subsets in untreated patients with chronic hepatitis B virus (HBV) infection and (ii) to examine the relationship between disturbances in the balance of lymphocyte subsets with liver disease and the presence of homosexuality.

Assessment of Prognostic Factors in Alcoholic Liver Disease: Toward a Global Quantitative Expression of Severity

Hector Orrego, Yedy Israel, Joan E. Blake, Alan Medline – 1 January 1983 – The prognostic significance of a battery of clinical, laboratory, and histological indicators was assessed in relation to mortality risk in a 1‐year study of 253 patients with alcoholic liver disease, of whom 51 died within such time. The relative risk associated with each abnormality was calculated. A number of abnormalities was found to be statistically associated with a higher risk of death.

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