Sarah Shefer, F. George Zaki, Gerald Salen – 1 January 1983 – The effect of high doses of chenodeoxycholic and ursodeoxycholic acids on hepatic morphology and on cholesterol and hile acid metabolism was examined in the rat. After 2 weeks of either cheno or ursodeoxycholic acid feeding, the livers of the treated rats revealed marked proliferation of the smooth endoplasmic reticulum which appeared as an adaptation phenomenon of the microsomal enzyme system in response to bile acid intake.

H. G. Weed – 1 January 1983

Michel Odièvre, Giuseppe Maggiore, Jean‐Claude Homberg, Fabrice Saadoun, Anne‐Marié Courouce, Jeannine Yvart, Michelle Hadchouel, Daniel Alagille – 1 January 1983 – A seroimmunologic evaluation of 57 children with chronic hepatitis is presented. Twenty‐one patients had chronic persistent hepatitis and 36 had chronic active hepatitis. Serum samples obtained before treatment were tested for HBsAg, anti‐HBs, anti‐HBc, smooth muscle antibody, and antibody to endoplasmic reticulum.

Daniel P. Rosenberg, Rachel Morecki, Lance O. Lollini, Joy Glaser, Charles E. Cornelius – 1 January 1983 – Extrahepatic biliary atresia was observed in a 6‐week‐old female rhesus monkey. Jaundice and conjugated hyperbilirubinemia were detected at the age of 6 days and persisted throughout life. At 6 weeks of age, the diagnosis of extrahepatic biliary atresia was established at exploratory laparotomy, and bile duct remnants were biopsied.

James L. Boyer – 1 January 1983

Merrill C. Johnson – 1 January 1983

Norbert W. Brattig, Peter A. Berg – 1 January 1983 – Sera from patients with acute viral hepatitis B were found to inhibit the in vitro proliferation of normal lymphocytes induced by different mitogens and antigens. In addition, an effect on concanavalin A‐induced T suppressor cell activity and pokeweed mitogen‐stimulated IgG and IgM synthesis was demonstrated.

Norbert W. Brattig, Gabriele E. Schrempf‐Decker, Christoph W. Brockl, Peter A. Berg – 1 January 1983 – Immunosuppressive factor(s) in sera from patients with acute viral hepatitis B [serum inhibition factor(s) (SIF)] which functioned like an antiactivator of lymphocytes were further characterized and purified. The active moiety could be separated from immunoglobulins and other serum proteins by means of gel filtration, anion exchange, and affinity chromatography. The major SIF activity always copurified with albumin.

Evangelista Sagnelli, Felice Piccinino, Giuseppe Manzillo, Francesca M. Felaco, Pietro Filippini, Giuseppe Maio, Giuseppe Pasquale, Crescenzo M. Izzo – 1 January 1983 – Two hundred and four patients with biopsy‐proven HBsAg‐positive chronic active hepatitis were treated for at least 2 years with azathioprine, prednisolone or a combination of both, or were untreated. Prevalences of HBeAg, anti‐HBe, and anti‐HBc were 26, 58, and 100%, respectively.

Suri Anand, Robert R. Schade, Carlos Bendetti, Robert Kelly, Bruce S. Rabin, John Krause, Thomas E. Starzl, Shunzaburo Iwatsuki, David H. Van Thiel – 1 January 1983 – A patient with coexistent hemochromatosis and alpha‐1‐antitrypsin deficiency which led to cirrhosis and death despite adequate therapy for hemochromatosis is reported. Evaluation of the family revealed first degree relatives with iron overload and others with alpha‐1‐antitrypsin deficiency but none with both conditions.