Morphologic and Biochemical Changes in Dogs After Portacaval Shunt Plus Bile Fistula or Ileal Bypass: Failure of Bile Fistula or Ileal Bypass to Prevent Hepatocyte Atrophy

Jon S. Thompson, Kendrick A. Porter, Nobuo Hayashida, Donald J. Mcnamara, Thomas S. Parker, William J. I. Russell, Antonio Francavilla, Thomas E. Starzl – 1 January 1983 – External biliary fistula (BF) or ileal bypass (IB) was performed in dogs at the time of or 2 weeks after portacaval shunt (PCS). The pathologic changes in the dog livers 2 to 4 weeks later were compared to those caused by PCS alone. Histopathologic differences between PCS alone vs. PCS plus BF or IB could not be found.

Plasma Norepinephrine, Weak Neurotransmitters, and Renin Activity During Active Tilting in Liver Cirrhosis: Relationship with Cardiovascular Homeostasis and Renal Function

Mauro Bernardi, Franco Trevisani, Costanza Santini, Giorgio Zoli, Mario Baraldini, Amedeo Ligabue, Giovanni Gasbarrini – 1 January 1983 – Derangements in cardiovascular homeostasis are well‐known features of liver failure. To evaluate the role of possible alterations in adrenergic and reninangiotensin systems in this context, tilting‐induced changes in plasma norepinephrine, octopamine, β‐phenylethanolamine, and plasma renin activity were related to modifications in blood pressure, heart rate, plasma volume, and renal function in 10 healthy controls and 20 patients with liver cirrhosis.

Hepatitis B Virus Status of Southern African Blacks with Hepatocellular Carcinoma: Comparison Between Rural and Urban Patients

Michael C. Kew, Elizabeth Rossouw, John Hodkinson, Alan Paterson, Geoffrey M. Dusheiko, J. Whitcutt Michael – 1 January 1983 – Hepatocellular carcinoma (HCC) is less common and occurs at a much older age in urban than in rural southern African Blacks. These differences may reflect differences in the etiology of the tumor in the two populations.

Ultrastructural Evidence of Intrahepatic Cholestasis Before and After Chenodeoxycholic Acid Therapy in Patients with Cholelithiasis: The National Cooperative Gallstone Study

M. James Phillips, Rosemarie L. Fisher, Deborah W. Anderson, Shu‐Ping Lan, John M. Lachin, James L. Boyer, The Steering Committee for the National Cooperative Gallstone Study Group – 1 January 1983 – Electron microscopy was performed to assess potential hepatotoxicity before and after 9 and 24 months of chenodeoxycholic acid (CDCA) therapy (375 or 750 mg, daily) in 103 patients with cholelithiasis.

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