The Effect of Progesterone on the Regulatory Mechanisms of Biliary Cholesterol Secretion in the Rat

Flavio O. Nervi, Reginald Del Pozo, Carmen F. Covarrubias, Beatriz O. Ronco – 1 January 1983 – We tested the hypothesis that progesterone, an inhibitor of cholesterol esterification in liver microsomes, increases biliary cholesterol output by increasing the availability of cholesterol. Initial bile samples of 20 min were obtained from acute bile fistula rats after seven daily doses of progesterone (5 to 55 mg per kg of body weight). Biliary cholesterol output correlated with the doses of progesterone, r = 0.64 (p < 0.005).

Hemodynamic Changes in Patients with Portal Venous Obstruction

Didier Lebrec, Christian Bataille, Eric Bercoff, Dominique Valla – 1 January 1983 – Splanchnic and systemic hemodynamics were evaluated in five adult patients with portal hypertension due to portal venous obstruction and were compared with those of patients with cirrhosis and those of a control group. In patients with portal venous obstruction, the gradient between wedged and free hepatic venous pressures ranged from 2 to 3 mm Hg, as in the control group, and was significantly lower than in patients with cirrhosis.

Morphologic and Biochemical Changes in Dogs After Portacaval Shunt Plus Bile Fistula or Ileal Bypass: Failure of Bile Fistula or Ileal Bypass to Prevent Hepatocyte Atrophy

Jon S. Thompson, Kendrick A. Porter, Nobuo Hayashida, Donald J. Mcnamara, Thomas S. Parker, William J. I. Russell, Antonio Francavilla, Thomas E. Starzl – 1 January 1983 – External biliary fistula (BF) or ileal bypass (IB) was performed in dogs at the time of or 2 weeks after portacaval shunt (PCS). The pathologic changes in the dog livers 2 to 4 weeks later were compared to those caused by PCS alone. Histopathologic differences between PCS alone vs. PCS plus BF or IB could not be found.

Plasma Norepinephrine, Weak Neurotransmitters, and Renin Activity During Active Tilting in Liver Cirrhosis: Relationship with Cardiovascular Homeostasis and Renal Function

Mauro Bernardi, Franco Trevisani, Costanza Santini, Giorgio Zoli, Mario Baraldini, Amedeo Ligabue, Giovanni Gasbarrini – 1 January 1983 – Derangements in cardiovascular homeostasis are well‐known features of liver failure. To evaluate the role of possible alterations in adrenergic and reninangiotensin systems in this context, tilting‐induced changes in plasma norepinephrine, octopamine, β‐phenylethanolamine, and plasma renin activity were related to modifications in blood pressure, heart rate, plasma volume, and renal function in 10 healthy controls and 20 patients with liver cirrhosis.

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