Jean‐Pierre Villeneuve, Hélène Fortunet‐Fouin, Dominique Arsène – 1 January 1983 – Following cimetidine administration, 60% of the dose is excreted as unchanged drug in the urine, and 40% is eliminated by metabolism. We evaluated the effect of liver disease on cimetidine disposition by comparing its kinetics in 7 healthy subjects and 8 patients with alcoholic cirrhosis.
Roberto J. Groszmann – 1 January 1983
Solomon Papper – 1 January 1983
James Markowitz, Fredric Daum, Ellen I. Kahn, Keith M. Schneider, Henry B. So, R. Peter Altman, Harvey W. Aiges, Garth Alperstein, Mervin Silverberg – 1 January 1983 – Differentiating intrahepatic cholestasis from extrahepatic biliary tract obstruction may be difficult. Four patients with intraoperative cholangiographic evidence of extrahepatic ductal atresia who underwent hepatoportoenterostomy are described. All were ultimately shown to have arteriohepatic dysplasia with hypoplastic but patent extrahepatic ductal systems.
K. P. Maier, H. Blum, W. Gerok, R. Herz, H. Berthold, Peter B. Gregory, Gianpaolo Molino, Alan F. Hofmann – 1 January 1983
Flavio O. Nervi, Reginald Del Pozo, Carmen F. Covarrubias, Beatriz O. Ronco – 1 January 1983 – We tested the hypothesis that progesterone, an inhibitor of cholesterol esterification in liver microsomes, increases biliary cholesterol output by increasing the availability of cholesterol. Initial bile samples of 20 min were obtained from acute bile fistula rats after seven daily doses of progesterone (5 to 55 mg per kg of body weight). Biliary cholesterol output correlated with the doses of progesterone, r = 0.64 (p < 0.005).
Sherman D. Levine – 1 January 1983
1 January 1983
Didier Lebrec, Christian Bataille, Eric Bercoff, Dominique Valla – 1 January 1983 – Splanchnic and systemic hemodynamics were evaluated in five adult patients with portal hypertension due to portal venous obstruction and were compared with those of patients with cirrhosis and those of a control group. In patients with portal venous obstruction, the gradient between wedged and free hepatic venous pressures ranged from 2 to 3 mm Hg, as in the control group, and was significantly lower than in patients with cirrhosis.