Cimetidine Kinetics and Dynamics in Patients with Severe Liver Disease

Jean‐Pierre Villeneuve, Hélène Fortunet‐Fouin, Dominique Arsène – 1 January 1983 – Following cimetidine administration, 60% of the dose is excreted as unchanged drug in the urine, and 40% is eliminated by metabolism. We evaluated the effect of liver disease on cimetidine disposition by comparing its kinetics in 7 healthy subjects and 8 patients with alcoholic cirrhosis.

Arteriohepatic Dysplasia. I. Pitfalls in Diagnosis and Management

James Markowitz, Fredric Daum, Ellen I. Kahn, Keith M. Schneider, Henry B. So, R. Peter Altman, Harvey W. Aiges, Garth Alperstein, Mervin Silverberg – 1 January 1983 – Differentiating intrahepatic cholestasis from extrahepatic biliary tract obstruction may be difficult. Four patients with intraoperative cholangiographic evidence of extrahepatic ductal atresia who underwent hepatoportoenterostomy are described. All were ultimately shown to have arteriohepatic dysplasia with hypoplastic but patent extrahepatic ductal systems.

The Effect of Progesterone on the Regulatory Mechanisms of Biliary Cholesterol Secretion in the Rat

Flavio O. Nervi, Reginald Del Pozo, Carmen F. Covarrubias, Beatriz O. Ronco – 1 January 1983 – We tested the hypothesis that progesterone, an inhibitor of cholesterol esterification in liver microsomes, increases biliary cholesterol output by increasing the availability of cholesterol. Initial bile samples of 20 min were obtained from acute bile fistula rats after seven daily doses of progesterone (5 to 55 mg per kg of body weight). Biliary cholesterol output correlated with the doses of progesterone, r = 0.64 (p < 0.005).

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