Arteriohepatic Dysplasia. I. Pitfalls in Diagnosis and Management

James Markowitz, Fredric Daum, Ellen I. Kahn, Keith M. Schneider, Henry B. So, R. Peter Altman, Harvey W. Aiges, Garth Alperstein, Mervin Silverberg – 1 January 1983 – Differentiating intrahepatic cholestasis from extrahepatic biliary tract obstruction may be difficult. Four patients with intraoperative cholangiographic evidence of extrahepatic ductal atresia who underwent hepatoportoenterostomy are described. All were ultimately shown to have arteriohepatic dysplasia with hypoplastic but patent extrahepatic ductal systems.

The Effect of Progesterone on the Regulatory Mechanisms of Biliary Cholesterol Secretion in the Rat

Flavio O. Nervi, Reginald Del Pozo, Carmen F. Covarrubias, Beatriz O. Ronco – 1 January 1983 – We tested the hypothesis that progesterone, an inhibitor of cholesterol esterification in liver microsomes, increases biliary cholesterol output by increasing the availability of cholesterol. Initial bile samples of 20 min were obtained from acute bile fistula rats after seven daily doses of progesterone (5 to 55 mg per kg of body weight). Biliary cholesterol output correlated with the doses of progesterone, r = 0.64 (p < 0.005).

Hemodynamic Changes in Patients with Portal Venous Obstruction

Didier Lebrec, Christian Bataille, Eric Bercoff, Dominique Valla – 1 January 1983 – Splanchnic and systemic hemodynamics were evaluated in five adult patients with portal hypertension due to portal venous obstruction and were compared with those of patients with cirrhosis and those of a control group. In patients with portal venous obstruction, the gradient between wedged and free hepatic venous pressures ranged from 2 to 3 mm Hg, as in the control group, and was significantly lower than in patients with cirrhosis.

Morphologic and Biochemical Changes in Dogs After Portacaval Shunt Plus Bile Fistula or Ileal Bypass: Failure of Bile Fistula or Ileal Bypass to Prevent Hepatocyte Atrophy

Jon S. Thompson, Kendrick A. Porter, Nobuo Hayashida, Donald J. Mcnamara, Thomas S. Parker, William J. I. Russell, Antonio Francavilla, Thomas E. Starzl – 1 January 1983 – External biliary fistula (BF) or ileal bypass (IB) was performed in dogs at the time of or 2 weeks after portacaval shunt (PCS). The pathologic changes in the dog livers 2 to 4 weeks later were compared to those caused by PCS alone. Histopathologic differences between PCS alone vs. PCS plus BF or IB could not be found.

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