Felix Witassek, Johannes Bircher, Philipp Huguenin, Rudolf Preisig – 1 January 1983 – The disposition of zomepirac was investigated in 18 patients with various liver diseases and in 10 healthy normal subjects in order to further test the hypothesis that glucuronidation of drugs may be spared in liver disease. Severity of the liver disease was assessed by the galactose elimination capacity. Following oral administration of zomepirac (200 mg), plasma and urinary drug concentrations were measured by high‐pressure liquid chromatography. Urine was assayed before and after alkaline hydrolysis.

Jay H. Lefkowitch, Kuo‐Ching Feng‐Chen, Jeffrey A. Sklar, Maureen B. Poh‐Fitzpatrick – 1 January 1983 – We studied the effects of cholic acid treatment on hepatic histology and ultrastructure in mice with griseofulvin‐induced protoporphyria. After 5 weeks of feeding griseofulvin alone, control mice developed darkly pigmented livers which by light microscopy showed birefringent, brown pigment deposits in bile ducts and ductules, sinusoidal Kupffer cell aggregates, and occasionally in hepatocytes and bile canaliculi.

Marshall M. Kaplan, Akiyuki Ohkubo, Elaine G. Quaroni, Duncan Sze‐Tu – 1 January 1983 – The following studies were done to determine the mechanism of the increse in rat liver alkaline phosphatase activity after bile duct ligation. Antiserum was raised in rabbits to highly purified rat liver alkaline phosphatase. In immune titration experiments, the 350% increase in rat liver alkaline phosphatase activity caused by bile duct ligation was paralleled by a similar increase in immuno‐precipitated alkaline phosphatase protein.

Alec Avgerinos, Peter Chu, Charles Greenfield, David S. Harry, Neil Mcintyre – 1 January 1983 – Serum lipids and lipoproteins were analyzed after an overnight fast, and following a fatty meal in 10 patients with cirrhosis, 5 with fatty liver, and 5 normal subjects. Cirrhotic patients were divided into two groups of five on the basis of serum lecithin‐cholesterol acyltransferase activity. Fasting triglyceride levels were similar in all four groups.

Luis Montano, Fernando Aranguibel, Margarita Boffill, Alison H. Goodall, George Janossy, Howard C. Thomas – 1 January 1983 – The composition of the mononuclear cell infiltrate in the liver was studied in patients with autoimmune and hepatitis B virus (HBV)‐induced liver disease. The ratio of inducer to cytotoxic/ suppressor cells was greater in patients with lupoid chronic active liver disease, primary biliary cirrhosis, and HBeAb positive HBV‐induced chronic active liver disease than in patients with HBeAg positive HBV‐induced chronic hepatitis.

Charles S Davidson, Milton M. Weiser – 1 January 1983

Robert S. Mccuskey, Franz J. Vonnahme, Martin Grun – 1 January 1983 – The livers of rats subjected to end‐to‐side portacaval anastomoses were studied 3 to 5 months postoperatively by in vivo and electron microscopy. Compared with sham‐operated controls, the livers of portacaval anastomoses animals contained dilated, tortuous networks of sinusoids. The velocity of blood flow in these vessels tended to be slower and more variable than controls, but always progressed toward the hepatic venules.

Ellen I. Kahn, Fredric Daum, James Markowitz, Harvey W. Aiges, Keith M. Schneider, Henry B. So, Peter Altman, Roma S. Chandra, Mervin Silverberg – 1 January 1983 – Five children were noted to have arteriohepatic dysplasia (Alagille's syndrome) between 3 and 7 months of age. Prior to diagnosis, four underwent Kasai procedures after intraoperative cholangio‐grams failed to demonstrate patency of the extrahepatic bile ducts. In three patients, a focal proximal hypoplasia of the common hepatic duct was demonstrated with fibrosis and increased vascularity.

Carmen Viola, Lydia Vineta, Jaime Bosch, Juan Rodés – 1 January 1983 – Two patients who presented with an exudative ascites in the course of typical acute type B hepatitis are reported. In one of them, ascites was associated with an exudative pleural effusion. In both patients, the clinical course of the hepatitis was uneventful, and ascites and pleural effusion disappeared spontaneously. Portal hypertension and common causes of exudative ascites were excluded.

Chia‐Ming Chu, Yun‐Fan Liaw, I‐Shyan Sheen, Deng‐Yn Lin, Miau‐Ju Huang – 1 January 1983 – Hepatitis B e antigen (HBeAg) and antibody (anti‐HBe) were studied by radioimmunoassay in consecutive series of 145 asymptomatic hepatitis B surface antigen (HBsAg) carriers, 389 patients with HBsAg‐positive chronic liver disease and 194 patients with HBsAg‐positive hepatocellular carcinoma, and compared between male and female subjects. The male to female ratio increased from 1.2 in asymptomatic carriers to 6.3 in chronic liver disease and 9.8 in hepatocellular carcinoma.