Histologic Studies of Severe Delta Agent Infection in Venezuelan Indians

Hans Popper, Swan N. Thung, Michael A. Gerber, Stephen C. Hadler, Mario De Monzon, Antonio Ponzetto, Elias Anzola, Dalia Rivera, Alejandro Mondolfi, Ana Bracho, Donald P. Francis, John L. Gerin, James E. Maynard, Robert H. Purcell – 1 January 1983 – To supplement a detailed epidemiologic study of an outbreak of viral hepatitis in Venezuelan Indians in isolated valleys, apparently resulting from delta agent infection, 10 autopsy specimens were studied histologically and immunocytochemically, and five biopsy specimens were examined.

Efficacy of Hepatitis B Immune Globulin for Prevention of Perinatal Transmission of the Hepatitis B Virus Carrier State: Final Report of a Randomized Double‐Blind, Placebo‐Controlled Trial

R. Palmer Beasley, Lu‐Yu Hwang, Cladd E. Stevens, Chia‐Chin Lin, Fon‐Jou Hsieh, Kwei‐Yu Wang, Tsu‐Shen Sun, Wolf Szmuness – 1 January 1983 – A randomized double‐blind, placebo‐controlled efficacy trial of hepatitis B immune globulin (HBIG) for prevention of the mother‐to‐infant transmitted HBsAg carrier state was conducted in Taiwan where the carrier rate in the general population is 15 to 20%. HBIG was given immediately after birth to infants of e antigen positive HBsAg carrier mothers, and all infants were followed for at least 15 months.

Gallbladder Glycoprotein Secretion in Mice with Hemolytic Anemia and Pigment Gallstones

J.Thomas LaMont, Bradley S. Turner, Seldon E. Bernstein, Bruce W. Trotman – 1 January 1983 – The nb/nb mouse with hereditary hemolytic anemia provides an animal model for the study of pigment gallstone disease. We measured glycoprotein synthesis and secretion in gallbladder neck and fundus of 6‐month‐old mice without stones, and in 12‐month‐old mice with and without stones in order to determine the effect of age and presence or absence of stones on mucin release.

Early Morphologic and Enzymatic Changes in Livers of Rats Treated with Chenodeoxycholic and Ursodeoxycholic Acids

Sarah Shefer, F. George Zaki, Gerald Salen – 1 January 1983 – The effect of high doses of chenodeoxycholic and ursodeoxycholic acids on hepatic morphology and on cholesterol and hile acid metabolism was examined in the rat. After 2 weeks of either cheno or ursodeoxycholic acid feeding, the livers of the treated rats revealed marked proliferation of the smooth endoplasmic reticulum which appeared as an adaptation phenomenon of the microsomal enzyme system in response to bile acid intake.

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