Spironolactone‐ and Canrenone‐Induced Changes in Hepatic (Na+, K+)ATPase Activity, Surface Membrane Cholesterol and Phospholipid, and Fluorescence Polarization in the Rat

Philip B. Miner, Michael Sneller, Synda S. Crawford – 1 January 1983 – We studied changes in hepatic membrane (Na+,K+)ATPase activity and membrane lipids induced by canrenoate, the water‐soluble congener of canrenone, the active metabolite of spironolactone. (Na+,K+)ATPase activity was decreased after canrenoate in a dose‐ and time‐dependent manner.

Detection of Regan Variant Type of Alkaline Phosphatase Isoenzyme in Liver Tissue of Indian Childhood Cirrhosis

S. R. Parekh, B. D. Patel, S. R. Damle, G. M. Thanki, D. Khutti – 1 January 1983 – Alkaline phosphatase (ALP) isoenzyme composition was studied in sera and liver from patients with Indian childhood cirrhosis (ICC). A typical pattern consisting of a fast‐moving anodal preliver band with slower moving diffuse liver and placental bands followed by an intestinal band was consistently observed in sera of patients in all stages of ICC and in pregnant mothers of index ICC patients. ICC liver ALP was relatively heat‐stable and inhibited by L‐phenylalanine and L‐leucine.

Vesicular Transport of Horseradish Peroxidase during Chronic Bile Duct Obstruction in the Rat

Richard H. Renston, Gyula Zsigmond, Robin A. Bernhoft, Susan J. Burwen, Albert L. Jones – 1 January 1983 – The vesicular transport system for biliary secretion of plasma‐derived proteins was investigated in rats with chronic bile duct obstruction. Horseradish peroxidase, previously demonstrated to be a suitable tracer for vesicular transport, was employed in these studies.

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