Eberhard Renner, Hubertus Wietholtz, Philipp Huguenin, Maurice J. Arnaud, Rudolf Preisig – 1 January 1984 – The effects of liver disease on caffeine plasma clearance (CI) and on exhalation of 14CO2 following i.v. injection of 2 μCi of [ 3‐methyl‐14C]caffeine together with 125 mg of the unlabeled compound were measured in 15 patients with cirrhosis, 11 subjects with miscellaneous liver disease, and 10 normal volunteers. Compared to mean values for CI (2.02 ± S.D.

David H. Van Thiel, Robert R. Schade, Thomas R. Hakala, Thomas E. Starzl, Donald Denny – 1 January 1984 – The incidence of prospective organ donors in the United States and the techniques which are to used to guarantee their optimal use after identification are analyzed. Attitudes of the public and health professionals toward organ donation are discussed.

Frank L. Iber – 1 January 1984

Christopher J. Burrell, Eric J. Gowans, Robert Rowland, Pauline Hall, Allison R. Jilbert, Barrie P. Marmion – 1 January 1984 – Liver sections from 18 patients positive for hepatitis B surface antigen (HBsAg), and from 12 negative patients, were examined for the presence of hepatitis B virus (HBV) DNA using an in situ hybridization assay that would identify only those hepatocytes containing more than 10 to 15 HBV genome equivalents per cell. Such cells are likely to be undergoing active viral replication, rather than latent infection.

Antoni Rimola, Ramón Soto, Felipe Bory, Vicente Arroyo, Carlos Piera, Joan Rodes – 1 January 1984 – The reticuloendothelial system phagocytic activity, estimated by the plasma elimination rate constant of 99mtechnetium‐sulfur colloid, was studied in 41 decompensated cirrhotics and 10 normal subjects. The results were related to the incidence and type of bacterial infections occurring during hospitalization and follow‐up, and to survival.

Nikolai V. Naumov, Mario Mondelli, Graeme J. M. Alexander, Richard S. Tedder, Adrian L. W. F. Eddleston, Roger Williams – 1 January 1984 – Previous studies demonstrated that peripheral blood lymphocytes are cytotoxic to autologous hepatocytes in patients with chronic hepatitis B virus infection. We examined whether cytotoxicity is specifically directed against hepatocytes expressing HBsAg or HBcAg.

Robert H. , Fennell Jr, Robert H. Shikes, John M. Vierling – 1 January 1983 – Histopathological features of nonsuppurative destructive cholangitis have been described in primary biliary cirrosis, chronic graft‐vs.‐host disease, and chronic rejection of human liver allografts. To determine whether or not susceptibility to injury of interlobular bile ducts was related to the original hepatobiliary disease requiring transplantation, we compared the histopathology of allografts transplanted into two groups of patients.

Charles S. Davidson – 1 January 1983

Marisabel Mourelle, Javier Cordero‐Hernández, Patricia Ponce‐Noyola, Marcos Rojkind – 1 January 1983 – Liver biomatrix contains a group of connective tissue components needed for attachment, survival, and maintenance of liver‐specific functions of adult rat hepatocytes in culture. An acidic extract of liver biomatrix that contains a group of glycoproteins can replace intact biomatrix in promoting attachment and survival of hepatocytes. However, except for albumin synthesis, liver‐specific functions have not been tested.

Geoffrey Dusheiko, Ernest Song, Sheila Bowyer, Michael Whitcutt, Gunthild Maier, Anthony Meyers, Mlchael C. Kew – 1 January 1983 – Hepatitis B virus (HBV) markers were measured in 83 immunosuppressed renal transplant patients who were followed for periods of 2 to 15 years. Sixty‐nine patients were negative for HBsAg before transplantation, of whom 14 were positive for anti‐HBs. The remaining 14 patients were HBsAg positive prior to transplantation. Eighteen patients were identified as being HBsAg positive during the follow‐up period.