John E. Coe, Kamal G. Ishak, Mary J. Ross – 1 January 1983 – An unusual and impressive hyperbilirubinemia was induced in Chinese hamsters by administration of diethylstilbestrol (DES). This icterus was dose‐dependent and affected females more severely than males. However, a similar mortality was detected in both sexes. Another hamster, the Armenian hamster, was even more susceptible to the icteric and lethal effects of DES. The hamster model of DES‐induced icterus showed many clinical dissimilarities when compared to the human estrogen‐induced jaundice, simple cholestatic jaundice.

John R. Senior – 1 January 1983

1 January 1983

E. Anthony Jones – 1 January 1983

Rashmi V. Patwardhan, Mack C. Mitchell, Raymond F. Johnson, Steven Schenker – 1 January 1983 – The effects of oral contraceptive steroids (OCS) on the disposition and elimination of lorazepam, oxazepam, and chlordiazepoxide were examined. Lorazepam and oxazepam are metabolized via glucuronidation while chlordiazepoxide is metabolized by oxidation in the liver. The disposition and elimination of lorazepam, oxazepam, and chlordiazepoxide was studied in females not taking OCS and females taking OCS (norethindrone acetate, 1 mg; ethinyl estradiol, 50 m̈g) for 6 months or more.

Jeffrey Rank, I. Dodd Wilson – 1 January 1983 – Polymeric IgA is rapidly transported from blood to bile by the rat liver. The effect of varying degrees of biliary obstruction on this transport process was studied. IgA concentrations were measured by radioimmunoassay. Serum IgA concentrations increased progressively, and IgA output in bile declined with increasing bile duct obstruction. The decline in bile IgA output was explained by both diminished bile flow and decreased concentrations of IgA in bile. Very little polymeric IgA was present in normal rat serum.

Floris M. J. Zuyderhoudt, Jan W. Sindram, Joannes J. M. Marx, George G. A. Jorning, Jacobus Van Gool – 1 January 1983 – Depot iron, ferritin iron, and ferritin protein were measured in 34 liver needle biopsy specimens obtained from patients with primary and secondary iron‐loading diseases.

Kurt H. Chau, Martha P. Hargie, Richard H. Decker, Isa K. Mushahwarand, Lacy R. Overby – 1 January 1983 – time sequence, relative reactivity, and persistence of anti‐HBc IgM were assessed in patients with HBsAg‐positive viral hepatitis. A solid‐phase immunoassay was developed using the IgM capture procedure with anti‐m̈ated polystyrene beads. HBcAg was purified from serum Dane particles and used as a probe with 125I‐labeled anti‐HBc IgG. This immunoassay exhibited a pronounced prozoning phenomenon, and relative titers of sera differed widely depending upon the dilution of serum tested.

Norman D. Grace – 1 January 1983

Brian R. D. Macdougall, Roger Williams – 1 January 1983 – In a prospective randomized double‐blind controlled trial, 51 patients, 16 with cirrhosis and 35 with extrahepatic portal hypertension all of whom presented with variceal bleeding, were given either long‐term cimetidine in a dosage of 1.6 gm daily (24 patients) or placebo tablets (27 patients). Thirty‐eight patients completed 2 years of treatment. For 16 patients with cirrhosis, there was no significant difference in the frequency of rebleeding between the cimetidine (62.5%) and placebo (75.0%) groups.