Adolf Stiehl, Richard Raedsch, Gerda Rudolph, Siegfried Walker – 1 January 1984 – In five patients with radiolucent gallstones, the effect of ursodeoxycholic acid (Urso) in doses of 250, 500, 750, 1,000, and 1,250 mg per day on biliary lipid and bile acid composition was studied. Biliary cholesterol decreased from 8.8 ± 0.8 mole% to 4.4 ± 0.2 mole% at 500 mg Urso per day (7.1 mg per kg) and to 4.2 ± 0.3 mole% at 750 mg Urso per day (10.7 mg per kg). Administration of 1,000 or 1,250 mg Urso per day produced no further decrease of biliary cholesterol.

Jean‐Claude Barbare, Raoul Poupon, Patrice Jaillon, Philippe Bories, Michele Aussanaire, François Darnis, Henri Michel, Georges Cheymol – 1 January 1984 – We studied the influence of posterior pituitary extract, vasopressin, and somatostatin on hepatic elimination function. Hepatic clearance and its two biological determinants, hepatic blood flow and metabolic activity (clearance Vmax/Km), were determined from hepatic indocyanine green elimination at steady‐state in cirrhotic patients.

Bruce F. Scharschmidt – 1 January 1984 – The results of liver transplantation in a total of 540 patients from four centers in the United States and Western Europe have been collated. Twenty‐five per cent of all transplants were performed for neoplastic disease. One– and 3–year survivals for this group were approximately 26 and 12% overall, and survival differed little for patients transplanted before and after January 1, 1980. Among the 44% of patients transplanted for endstage cirrhosis, 3–year survival was lowest for patients with alcoholic cirrhosis (20%).

David Schachter – 1 January 1984

Steven Schenker – 1 January 1984

Steven Schenker – 1 January 1984

Charles S. Davidson, Raymond S. Koff – 1 January 1984

Irwin H. Rosenberg – 1 January 1984

Naoto Aoki, Michael A. Gerber, Swan N. Thung, Mei‐Ling Chen, Judith K. Christman, Peter M. Price, Christos S. Flordellis, George Acs – 1 January 1984 – Cultured 3T3 mouse fibroblasts transfected with cloned hepatitis B virus genome and DNA coding for methotrexate‐resistant dihydrofolate reductase, produce and secrete significant amounts of hepatitis B surface antigen (HBsAg).

Peter G. Mavrelis, Helmut V. Ammon, John J. Gleysteen, Richard A. Komorowski, Ursula K. Charaf – 1 January 1983 – Alcoholic liver disease is characterized by the accumulation of fat and inflammatory changes in the liver. Because free fatty acids, the precursors of triglycerides, can damage biological membranes, accumulation of free fatty acids in the liver might be in part responsible for the functional and morphological changes seen in alcoholic liver disease.