Prognosis of Primary Hepatocellular Carcinoma

Kunio Okuda, Hiroshi Obata, Yukio Nakajima, Toshio Ohtsuki, Nobuo Okazaki, Kunihiko Ohnishi – 1 January 1984 – Prognosis of 600 consecutive patients with hepatocellular carcinoma was analyzed in relation to treatment. They were divided into three stages based on four parameters of advanced disease: ascites, tumor greater than 50% of the two‐dimensional size of the liver, serum albumin below 3 gm per dl, and serum bilirubin above 3 mg per dl. Stage I had none of these signs; Stage II one or two signs, and Stage III three or all signs.

Hepatic Graft Versus Host Disease: A Study of the Predictive Value of Liver Biopsy in Diagnosis

Dale C. Snover, Sally A. Weisdorf, Norma K. Ramsay, Philip Mcglave, John H. Kersey – 1 January 1984 – Ninety‐six liver biopsies [32 bone marrow transplant (BMT), 7 pre‐BMT, and 57 non‐BMT] are reviewed for histological evidence of graft versus host disease (GVHD), based on bile duct atypia and related inflammatory changes. In addition, the presence of cholestasis, piecemeal necrosis, and attachment of lymphocytes to vascular endothelium (endothelialitis) are evaluated.

Effect of Ursodeoxycholic Acid on Biliary Bile Acid and Bile Lipid Composition in Gallstone Patients

Adolf Stiehl, Richard Raedsch, Gerda Rudolph, Siegfried Walker – 1 January 1984 – In five patients with radiolucent gallstones, the effect of ursodeoxycholic acid (Urso) in doses of 250, 500, 750, 1,000, and 1,250 mg per day on biliary lipid and bile acid composition was studied. Biliary cholesterol decreased from 8.8 ± 0.8 mole% to 4.4 ± 0.2 mole% at 500 mg Urso per day (7.1 mg per kg) and to 4.2 ± 0.3 mole% at 750 mg Urso per day (10.7 mg per kg). Administration of 1,000 or 1,250 mg Urso per day produced no further decrease of biliary cholesterol.

The Influence of Vasoactive Agents on Metabolic Activity of the Liver in Cirrhosis: A Study of the Effects of Posterior Pituitary Extract, Vasopressin, and Somatostatin

Jean‐Claude Barbare, Raoul Poupon, Patrice Jaillon, Philippe Bories, Michele Aussanaire, François Darnis, Henri Michel, Georges Cheymol – 1 January 1984 – We studied the influence of posterior pituitary extract, vasopressin, and somatostatin on hepatic elimination function. Hepatic clearance and its two biological determinants, hepatic blood flow and metabolic activity (clearance Vmax/Km), were determined from hepatic indocyanine green elimination at steady‐state in cirrhotic patients.

Human Liver Transplantation: Analysis of Data on 540 Patients from Four Centers

Bruce F. Scharschmidt – 1 January 1984 – The results of liver transplantation in a total of 540 patients from four centers in the United States and Western Europe have been collated. Twenty‐five per cent of all transplants were performed for neoplastic disease. One– and 3–year survivals for this group were approximately 26 and 12% overall, and survival differed little for patients transplanted before and after January 1, 1980. Among the 44% of patients transplanted for endstage cirrhosis, 3–year survival was lowest for patients with alcoholic cirrhosis (20%).

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