Paul R. Harmatz, Ronald E. Kleinman, Bruce W. Bunnell, Daniel T. Mcclenathan, W. Allan Walker, Kurt J. Bloch – 1 January 1984 – The clearance of circulating IgA immune complexes following acute bile duct obstruction was investigated in this study. IgA immune complexes were formed in vitro from MOPC‐315, an IgA M‐component with anti‐dinitrophenyl (DNP) specificity, and 125I‐DNP10 bovine serum albumin (BSA). Eighteen hours after laparotomy during which the common bile duct was either identified only or identified and ligated, the IgA immune complexes were injected intravenously.

Okio Hino, Tomoyuki Kitagawa, Katsuro Koike, Midori Kobayashi, Mitsuru Hara, Wataru Mori, Toshiro Nakashima, Nobu Hattori, Haruo Sugano – 1 January 1984 – Hepatitis B virus (HBV) DNA in hepatocellular carcinoma (HCC) and/or cirrhotic livers of Japanese patients in Japan was investigated by molecular hybridization utilizing a 32P‐labeled cloned HBV DNA of adr subtype. Among 24 HCC cases, 9 (37.5%) were positive for serum HBsAg and 10 (41.7%), including 2 cases which were negative for serum HBV markers, were positive for tissue HBsAg in noncancerous portions of the liver.

Kerry J. Breen, Ross W. Bury, Ian V. Calder, Paul V. Desmond, Marion Peters, M. Laurie Mashford – 1 January 1984 – Phenacetin, a high‐clearance drug, was labeled as [14C‐ethyl]phenacetin and used in a breath test of hepatic function. 14CO2 appeared rapidly in breath such that more than 30% of the administered radioactivity was expired in 2 hr. For all means of expression used to describe the appearance of 14CO2 in breath, normal controls and hospitalized patients without liver disease were clearly separated from cirrhotic subjects with moderate and severe liver damage.

Irmin Sternlieb – 1 January 1984 – The clinical course of certain patients with Wilson's disease resembles that of patients with viral or drug‐induced fulminant hepatitis lasting only few weeks from recognition of symptoms to severe hepatic insufficiency and death. The disease is complicated by hemolysis and is characterized by hypercupremia. Routine laboratory findings may underestimate the severity of the disease. These patients, as well as patients with decompensated Wilsonian cirrhosis who are not responding to therapy, should be considered as candidates for liver transplants.

1 January 1984

Robert A. Kane – 1 January 1984

Don Paul Jones – 1 January 1984

Irwinm Arias – 1 January 1984

George B. Mcdonald, Pankaj Sharma, David E. Matthews, Howard M. Shulman, E. Donnall Thomas – 1 January 1984 – Venocclusive disease (VOD) of the liver, a fibrous obliteration of small hepatic venules, can be caused by chemoradiation therapy. We reviewed 255 consecutive patients undergoing bone marrow transplantation for malignancy during 1978 to 1980 in order to determine the incidence of VOD and the predisposing factors. Fifty‐three of 255 patients met our criteria for VOD, for an incidence of 21%.

Peter Ferenci, S. Chris Pappas, Peter J. Munson, E. Anthony Jones – 1 January 1984 – The status of the excitatory glutamatergic neurotransmitter system in hepatic encephalopathy has been studied. Synaptic membranes (SM) were prepared from the brains of normal rabbits, hyperammonemic normal rabbits, and rabbits with fulminant hepatic failure.