Simon Bar‐Meir, Zamir Halpern, Eithan Bardan, Tuvia Gilat – 1 March 1984 – Four hundred and fifty‐four consecutive patients who had had their gallbladder removed were interviewed to determine the presence of upper abdominal pain, increased serum alkaline phosphatase and/or serum amylase activity. Patients with unexplained upper abdominal pain and/or enzyme abnormalities were offered endoscopic retrograde cholangiopancreatography (ERCP) and manometric evaluations.

Joyce Carlson, Sten Eriksson, Ragnar Alm, Thomas Kjellstrom – 1 March 1984 – The human hepatoma cell line PLC/PRF/5 synthesized and secreted a functioal α‐antitrypsin (α‐AT) glycoprotein with normal molecular size but retarded electrophoretic mobility.

Sohrab A. Mobarhan, Robert M. Russell, Robert R. Recker, David B. Posner, Frank L. Iber, Pamela Miller – 1 March 1984 – In a study of 56 alcoholics with liver cirrhosis, 18 (32%) had decreased bone density and low levels of serum 25‐hydroxyvitamin D (25‐OH‐D) (<20 ng per ml).

Douglas Horst, Norman D. Grace, Harold O. Conn, Eugene Schiff, Steven Schenker, Alfredo Viteri, David Law, Colin E. Atterbury – 1 March 1984 – A randomized study was conducted in 37 hospitalized patients at six cooperating hospitals in which protein‐intolerant cirrhotic patients were fed increasing amounts of either dietary protein or a branched‐chain enriched amino acid solution (BCAA) until they attained an intake of 80 gm protein per day or equivalent or until they developed stage 2 encephalopathy.

Attallah Kappas, George S. Drummond, Creuza S. Simionatto, Karl E. Anderson – 1 March 1984

Thomas S. Edgington – 1 March 1984

William M. Rand – 1 March 1984

Rosa M.

Mario Frezza, Gabriele Pozzato, Lucio Chiesa, Giorgio Stramentinoli, Carlo Di Padova – 1 March 1984 – Previous investigations have indicated that S‐adenosyl‐L‐methionine (SAMe) leads to reversal of estrogen‐induced bile flow impairment in rats. This randomized, single‐blind clinical trial was performed to determine whether SAMe reverses intrahepatic cholestasis of pregnancy (ICP) which occurs in hypersensitive women associated with increased estrogen levels in late pregnancy.

Serge Erlinger, Alice Le Go, Jean‐Marc Husson, Johan Fevery – 1 March 1984 – A double‐blind randomized, multicenter study was carried out to determine the efficacy and safety of ursodeoxycholic acid (UDCA) at 4 doses of 2.1 to 16.2 mg‐kg−1 day−1, and chenodeoxycholic acid (CDCA) at the dose of 16.9 mg‐kg−1 ‐day−1, in 197 patients treated for up to 1 year for radiolucent gallstones in functioning (opacified) gallbladders.