Bertram I. Cohen, Anil K. Singhal, Richard J. Stenger, Patricia May‐Donath, Judith Finver‐Sadowsky, Charles K. Mcsherry, Erwin H. Mosbach – 1 March 1984 – The prevention of cholesterol cholelithiasis by dietary chenodeoxycholic and ursodeoxycholic acids was studied in the male prairie dog (Cynotttys ludovicianus). Gallstones were induced by administration of a semisynthetic diet containing 0.4% cholesterol for a period of 8 weeks. Groups of 5 or 6 animals received the lithogenic diet with added chenodeoxycholic or ursodeoxycholic acid (0.03% “low dose” or 0.06% “high dose”).

William Allan Tisdale – 1 March 1984

Luc Bouwens, Marijke Baekeland, Eddie Wisse – 1 March 1984 – Partial hepatectomy and a single intravenous injection of zymosan were used to provoke expansion of the Kupffer cell population in rat liver. The number of Kupffer cells per microscopic field increased exponentially for 4 to 5 days after either stimulation. During this exponential growth phase, high mitotic activity of Kupffer cells was observed.

Christian Beaubernard, Marie‐Louise Delorme, Pierre Opolon, Mlchele Boschat, Joelle Morin, Marie‐Plerre Oryszcyn, Dominique Franco – 1 March 1984 – The aim of this study was to investigate the effect of oral administration of branched‐chain amino acid (BCAA)‐enriched diets after portacaval shunt (PCS) in rats. Fifty‐one Sprague‐Dawley male rats (200 gm) underwent PCS and 55 a sham operation. Half of the animals received BCAA 142 mg per day through a gastric tube; the other half underwent a sham procedure.

Takeshi Okanoue, Isao Kondo, Thomas J. Ihrig, Samuel W. French – 1 March 1984 – In order to demonstrate the effect to the acute administration of ethanol and chlorpromazine (CPZ) on bile flow and transhepatic transport of horseradish peroxidase (HRP) into bile, male rats were administered either 5 gm per kg ethanol intragastrically (E‐rats) or 3 mg per kg CPZ intraperitoneally (CPZ rats). Control rats (C‐rats) received saline. Two hours after ethanol feeding or 90 min after CPZ injection HRP was injected into the portal vein, and bile samples were collected at 1 0‐min intervals for 2 hr.

Hyman J. Zimmerman, James H. Lewis, Kamal G. Ishak, Willis C. Maddrey – 1 March 1984 – Ticrynafen, a uricosuric diuretic, was withdrawn from clinical use in the United States in 1980 after having been implicated as the cause of a number of instances of serious hepatic injury. In this report, we analyze 340 cases of ticrynafen‐associated hepatic disease reported to the manufacturer from the time of initial marketing until shortly after the drug had been recalled. Jaundice was recorded in 246 of 287 patients with sufficient clinical information, and 25 (10.2%) of these icteric patients died.

Eugene Roberts – 1 March 1984

Oscar W. Portman, Jayanta Roy Chowdhury, Namita Roy Chowdhury, Manfred Alexander, Charles E. Cornelius, Irwin M. Arias – 1 March 1984 – A Bolivian population of squirrel monkeys, Saimiri sciureus, exhibits several features of Gilbert's syndrome in man, and is proposed as a nonhuman primate model of the condition. The Bolivian population was found to have higher fasting (40.6 ± 2.7 μM; mean ± S.E.) and postcibal (9.9 ± 0.9 μM) plasma unconjugated bilirubin concentrations (p < 0.001) than a closely related Brazilian population (fasting 5.5 ± 0.7 μM); postcibal (2.4 ± 0.7 μM).

Charles S. Davidson, William G. M. Hardison – 1 March 1984

Hans Schomerus, Karl H. Wiedmann, Wolfgang Dölle, Herrmann Peerenboom, Georg Strohmeyer, Klaus Balzer, Harald Goebell, Hans K. Dürr, Christian Bode, André L. Blum, Gert Frösner, Wolfram Gerlich, Peter A. Berg, Klaus Dietz – 1 March 1984 – One‐hundred sixty patients (81 cyanidanol, 79 placebo) were included in a double‐blind placebo‐controlled clinical trial to evaluate the effect of 3 gm (+)‐cyanidanol‐3 per day for 8 weeks on the clinical course of acute viral hepatitis and HBsAg elimination. Quantitative determination of HBsAg was performed at frequent intervals.