Franco‐Belgian Cooperative Study of Ursodeoxycholic Acid in the Medical Dissolution of Gallstones: A Double‐Blind, Randomized, Dose‐Response Study, and Comparison with Chenodeoxycholic Acid

Serge Erlinger, Alice Le Go, Jean‐Marc Husson, Johan Fevery – 1 March 1984 – A double‐blind randomized, multicenter study was carried out to determine the efficacy and safety of ursodeoxycholic acid (UDCA) at 4 doses of 2.1 to 16.2 mg‐kg−1 day−1, and chenodeoxycholic acid (CDCA) at the dose of 16.9 mg‐kg−1 ‐day−1, in 197 patients treated for up to 1 year for radiolucent gallstones in functioning (opacified) gallbladders.

Reversal of Intrahepatic Cholestasis of Pregnancy in Women after High Dose S‐Adenosyl‐L‐Methionine Administration

Mario Frezza, Gabriele Pozzato, Lucio Chiesa, Giorgio Stramentinoli, Carlo Di Padova – 1 March 1984 – Previous investigations have indicated that S‐adenosyl‐L‐methionine (SAMe) leads to reversal of estrogen‐induced bile flow impairment in rats. This randomized, single‐blind clinical trial was performed to determine whether SAMe reverses intrahepatic cholestasis of pregnancy (ICP) which occurs in hypersensitive women associated with increased estrogen levels in late pregnancy.

Comparison of Dietary Protein with an Oral, Branched Chain‐Enriched Amino Acid Supplement in Chronic Portal‐Systemic Encephalopathy: A Randomized Controlled Trial

Douglas Horst, Norman D. Grace, Harold O. Conn, Eugene Schiff, Steven Schenker, Alfredo Viteri, David Law, Colin E. Atterbury – 1 March 1984 – A randomized study was conducted in 37 hospitalized patients at six cooperating hospitals in which protein‐intolerant cirrhotic patients were fed increasing amounts of either dietary protein or a branched‐chain enriched amino acid solution (BCAA) until they attained an intake of 80 gm protein per day or equivalent or until they developed stage 2 encephalopathy.

Metabolic Bone Disease in Alcoholic Cirrhosis: A Comparison of the Effect of Vitamin D2 25‐Hydroxyvitamin D, or Supportive Treatment

Sohrab A. Mobarhan, Robert M. Russell, Robert R. Recker, David B. Posner, Frank L. Iber, Pamela Miller – 1 March 1984 – In a study of 56 alcoholics with liver cirrhosis, 18 (32%) had decreased bone density and low levels of serum 25‐hydroxyvitamin D (25‐OH‐D) (<20 ng per ml).

Frequency of Papillary Dysfunction Among Cholecystectomized Patients

Simon Bar‐Meir, Zamir Halpern, Eithan Bardan, Tuvia Gilat – 1 March 1984 – Four hundred and fifty‐four consecutive patients who had had their gallbladder removed were interviewed to determine the presence of upper abdominal pain, increased serum alkaline phosphatase and/or serum amylase activity. Patients with unexplained upper abdominal pain and/or enzyme abnormalities were offered endoscopic retrograde cholangiopancreatography (ERCP) and manometric evaluations.

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