Alterations in Endothelial Fenestrations in Liver Sinusoids of Baboons Fed Alcohol: A Scanning Electron Microscopic Study

Ki M. Mak, Charles S. Lieber – 1 May 1984 – The effects of chronic alcohol consumption on the ultrastructure of endothelial fenestrations in liver sinusoids were studied by scanning electron microscopy in surgical liver biopsies of 16 baboons pair‐fed with nutritionally adequate diets containing alcohol or isocaloric carbohydrate for up to 112 months. Alcohol consumption for 4 to 24 months resulted in a decreased number of fenestrations (1.4 per μm2 of the endothelial surface vs. 3.3 in pair‐fed controls; p < 0.01) and an increase in their geometric mean diameter (115.6 vs.

Lack of Glucagon Receptors in Morris Hepatoma 7800

Marisabel Mourelle, Marcos Rojkind – 1 May 1984 – When compared to normal liver membranes, purified plasma membranes of regenerating liver and Morris hepatomas contain low but variable capacities to bind glucagon. This property is inversely related to the capacity of the isolated hepatocytes to bind to heterologous biomatrix glycoproteins. Since these parameters are characteristic of the proliferative state of the cells, it was important to further study the glucagon receptor protein and stimulation of adenylate cyclase activity.

Acute Hepatitis A Infection in Hepatitis B Chimpanzee Carriers

Kwesi N. Tsiquaye, Tim J. Harrison, Bernard Portmann, Shanlian Hu, Arie J. Zuckerman – 1 May 1984 – Two hepatitis B virus carrier chimpanzees which were superinfected with hepatitis A virus developed acute hepatitis followed by the production of antibodies to hepatitis A virus. The Southern blot technique employed to monitor liver hepatitis B virus DNA revealed that the amount of viral DNA in both animals was significantly reduced during the acute phase of hepatitis A infection. The levels of plasma hepatitis B DNA polymerase activity were also reduced in one chimpanzee.

Hepatic Transport of Sulfated and Non‐Sulfated Bile Acids in the Rat Following Relief of Bile Duct Obstruction

D. Paul Cleland, T. Carl Bartholomew, Barbara H. Billing – 1 May 1984 – The effect of bile duct ligation for 5 days on the hepatic transport of sulfated and nonsulfated bile acids was studied. Tracer doses of radioactive bile acids [3H]taurochenodeoxycholate‐3‐sulfate [3H]chenodeoxycholate‐3‐sulfate, [3H]taurochenodeoxycholic acid and [14C]taurocholic acid were injected 90 min after relief of obstruction when the plasma total bile acid concentration had reverted to normal.

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