Wilson's disease: Transplantation when all else has failed

Irmin Sternlieb – 1 July 1988 – Experience with liver transplantation for patients with Wilson's disease who have major neurological impairment is limited, and this report describes the results obtained in two such patients. The first was a 30‐year‐old man with a 14‐month history of hepatic and neurological impairment. In spite of treatment with d‐penicillamine, he developed increasing dysarthria, dysphagia, akinesia and rigidity of all four limbs, and required continuous nursing care.

Phospholipids and bile acids as diffusional carriers of Na+ across nonpolar media

Luigi Accatino, Patricia Gavilan – 1 July 1988 – Phospholipids and bile acids, by virtue of their amphiphilic properties, can interact in nonpolar media forming “inverted” structures (micelles) which presumably have an hydrophilic core and might act as diffusional carriers (ionophores) of electrolytes across low dielectric constant media or lipid membranes.

Thallium‐201 per rectum for the diagnosis of cirrhosis in patients with asymptomatic chronic hepatitis

Agesilao D'Arienzo, Luigi Celentano, Alessandro Scuotto, Pasqualina Di Siervi, Vinicio Lombardi, Giovanni Squame, Gabriele Mazzacca – 1 July 1988 – In normal subjects, thallium‐201, administered per rectum, is taken up mainly by the liver (heart/liver ratio in normal subjects: 0.04 to 0.12). It has been claimed that an increased heart/liver ratio is suggestive of portal‐caval shunting and portal hypertension.

Characterization of H+ efflux pathways in rat hepatocytes

M. Sawkat Anwer, Kathleen Nolan – 1 July 1988 – A pH‐stat method was used to characterize H+ efflux pathways in hepatocytes in order to determine if Na+/ H+ and Ca++/H+ exchange are involved in H+ efflux from hepatocytes under basal conditions and if cyclic AMP analogs affect Na+/H+ exchange. Total H+ efflux of freshly prepared hepatocytes ranged from 10 to 15 nmoles per min per mg protein. A part of total H+ efflux (35 to 50%) was dependent on extracellular Na+.

Effects of vasopressin on the intravariceal pressure in patients with cirrhosis: Comparison with the effects on portal pressure

Jaime Bosch, Josep M. Bordas, Ricardo Mastai, David Kravetz, Miquel Navasa, Jaime Chesta, M. Pilar Pizcueta, Juan C. García‐Pagán, Joan Rodés – 1 July 1988 – The present study investigated to what extent measurements of wedged and free hepatic venous pressures adequately reflect the effects of vasopressin at the esophageal varices in patients with cirrhosis.

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