A radioimmunoassay procedure for type III procollagen: Its use in the detection of hepatic fibrosis

Michael R. Galambos, Delwood C. Collins, John T. Galambos – 1 January 1985 – Recent studies suggest that the serum level of Type III procollagen (PC‐III) could be a valuable, noninvasive monitor of hepatic fibrogenesis. We have developed a sensitive and specific radioimmunoassay for PC‐III procollagen isolated and purified from fetal goat skin which shows high cross‐reaction for human PC‐III. In a double‐blind study, serum samples taken from 8 normal volunteers and 50 patients at the time of liver biopsy were assayed for PC‐III.

Liver morphology in southern african blacks with hepatocellular carcinoma: A study within the urban environment

Alan C. Paterson, Michael C. Kew, Allen A. B. Herman, Pieter J. Becker, John Hodkinson, Charles Isaacson – 1 January 1985 – Hepatocellular carcinoma has a lower prevalence and presents at a later age in urban Blacks than in rural Blacks. These differences have previously been shown not to be attributable to differences in serum hepatitis B virus markers.

Pigment gallstone formation in the cholesterol‐fed guinea pig

Wayne W. Lamorte, Erica A. Brotschi, Thayer E. Scott, Lester F. Williams – 1 January 1985 – Female Hartley guinea pigs fed a 0.5% cholesterol‐supplemented diet were found to form pigmented gallstones after 6 weeks (17/23) and 12 weeks (11/11), while only 2 of 44 animals fed a trace cholesterol diet formed gallstones over a comparable period. The light brown stones consisted primarily of aggregates of fine granular crystals, morphologically similar to calcium bilirubinate crystals.

The diagnosis of bacterial peritonitis: Comparison of pH, lactate concentration and leukocyte count

Guadalupe Garcia‐Tsao, Harold O. Conn, Emanuel Lerner – 1 January 1985 – It has been suggested that the hydrogen ion and lactate concentrations may be superior to the polymorphonuclear cell count (PMN) in ascitic fluid, in the diagnosis of bacterial peritonitis (BP). In order to compare the diagnostic accuracy of ascitic fluid measurements of pH, lactate, glucose and the PMN in BP, we analyzed the ascitic fluids of 70 consecutive patients in whom pH, lactate, glucose and the PMN count were measured in ascitic fluid and arterial blood.

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