Bertrand Nalpas, Anne Vassault, Alain Le Guillou, Bruno Lesgourgues, Nicolas Ferry, Bernard Lacour, Pierre Berthelot – 1 September 1984 – Serum activity of the mitochondrial isoenzyme of aspartate aminotransferase (mAST) was measured with an immunological method in 74 subjects. Fourty‐six were chronic alcoholics with (30) or without (16) obvious alcoholic liver disease; 28 were nonalcoholic controls among whom 14 had acute or chronic viral hepatitis, the remaining 14 being healthy individuals.

Ernest Seidman, Andrée M. Weber, Claude L. Morin, Roméo Ethier, Jacques B. Lamarche, Ara J. Guerguérian, Guy Geoffroy, Claude C. Roy – 1 September 1984 – A child with cryptogenic cirrhosis underwent a third session of elective sclerotherapy. Endoscopic therapy consisted of intravascular injection of ethanolamine oleate in varices newly developed at the midesophagus level. Irreversible paraplegia was documented within 8 hr postoperatively. Two years later she eventually died from gastrointestinal bleeding.

1 September 1984

Edward W. Moore – 1 September 1984 – Calcium is present in all pigment gallstones as a salt of one or more of the anions in bile which are most readily precipitable by calcium: (i) carbonate; (ii) bilirubinate; (iii) phosphate, and (iv) “palmitate”. We term these “calcium‐sensitive” anions.

Donald M. Small, Donna J. Cabral, David P. Cistola, John S. Parks, James A. Hamilton – 1 September 1984 – The ionization behavior of carboxylic acids including aliphatic chain fatty acids and bile acids in solutions, micelles, membranes and proteins is of considerable biological interest. The 13C nuclear magnetic resonance chemical shift of carboxyl carbon of a variety of acids has been shown to be a linear function of the state of ionization of the carboxyl group.

Natarajan Rajagopalan, Siegfried Lindenbaum – 1 September 1984 – The binding of Ca2+ to micelles of glycine and taurine bile acid conjugates was studied using a Ca2+−‐specific electrode. An investigation of the effect of buffer concentration, pH, added electrolyte and lecithin was also performed. The results indicate that the binding of Ca2+ to bile salt micelles is dependent on the number of hydroxyl groups on the steroid nucleus and on the nature of the head conjugating group, namely, glycine or taurine.

1 September 1984

Joseph B. Bogardus – 1 September 1984 – Monooctanoin is used clinically for dissolution of common bile duct cholesterol gallstones. A number of factors influencing the dissolution rate of cholesterol monohydrate in this solvent were investigated. Water increased cholesterol dissolution rate in a manner inconsistent with previous solubility measurements. Dissolution rate increased approximately 50% in the presence of 10 to 15% water in monooctanoin.

Yun‐Fan Liaw, Miau‐Ju Huang, Chia‐Ming Chu, I‐Shyan Sheen, Deng‐Yn Lin – 1 July 1984 – To examine the period between disappearance of hepatitis B e antigen (HBeAg) and appearance of anti‐HBe, 48 patients with clinicopathologically verified chronic B hepatitis were followed every 1 to 3 months after HBeAg clearance. Sera were tested by radioimmunoassay for HBeAg and anti‐HBe. Anti‐HBe appeared in days to years, mostly (78.7%) within 1 year, after disappearance of HBeAg. Only 40.5% of patients had an “e‐window” shorter than 1 month.

Bruno Descos, Olivier Bernard, Francis Brunelle, Jacques Valayer, Delphine Feldmann, Michelle Hadchouel, Daniel Alagille – 1 July 1984 – Ten infants of less than 6 months of age presented with cholestatic jaundice and gallstones. Jaundice occurred after a lag period, and sepsis was present in three children. Ultrasound examination showed dilatation of intrahepatic and extrahepatic bile ducts in eight patients and detected cholelithiasis in three.