Natarajan Rajagopalan, Siegfried Lindenbaum – 1 September 1984 – The binding of Ca2+ to micelles of glycine and taurine bile acid conjugates was studied using a Ca2+−‐specific electrode. An investigation of the effect of buffer concentration, pH, added electrolyte and lecithin was also performed. The results indicate that the binding of Ca2+ to bile salt micelles is dependent on the number of hydroxyl groups on the steroid nucleus and on the nature of the head conjugating group, namely, glycine or taurine.

1 September 1984

Joseph B. Bogardus – 1 September 1984 – Monooctanoin is used clinically for dissolution of common bile duct cholesterol gallstones. A number of factors influencing the dissolution rate of cholesterol monohydrate in this solvent were investigated. Water increased cholesterol dissolution rate in a manner inconsistent with previous solubility measurements. Dissolution rate increased approximately 50% in the presence of 10 to 15% water in monooctanoin.

Yun‐Fan Liaw, Miau‐Ju Huang, Chia‐Ming Chu, I‐Shyan Sheen, Deng‐Yn Lin – 1 July 1984 – To examine the period between disappearance of hepatitis B e antigen (HBeAg) and appearance of anti‐HBe, 48 patients with clinicopathologically verified chronic B hepatitis were followed every 1 to 3 months after HBeAg clearance. Sera were tested by radioimmunoassay for HBeAg and anti‐HBe. Anti‐HBe appeared in days to years, mostly (78.7%) within 1 year, after disappearance of HBeAg. Only 40.5% of patients had an “e‐window” shorter than 1 month.

Bruno Descos, Olivier Bernard, Francis Brunelle, Jacques Valayer, Delphine Feldmann, Michelle Hadchouel, Daniel Alagille – 1 July 1984 – Ten infants of less than 6 months of age presented with cholestatic jaundice and gallstones. Jaundice occurred after a lag period, and sepsis was present in three children. Ultrasound examination showed dilatation of intrahepatic and extrahepatic bile ducts in eight patients and detected cholelithiasis in three.

Yukio Yokoi, Toshihiko Namihisa, Hlroyuki Kuroda, Ikutoshi Komatsu, Akihisa Miyazaki, Sumio Watanabe, Koh Usui – 1 July 1984 – Desmin is a smooth muscle protein consisting of intermediate filaments. It is also present in other cell types. We obtained desmin antibodies from New Zealand white rabbits which were immunized with desmin following its extraction from chicken gizzard smooth muscle. By immunocytochemical methods, the antibody stained the Z‐line of rat skeletal myofibrils and produced only one band with chicken gizzard desmin by immunoblotting.

Ardythe A. Mccracken, Merrill Emmett, Alfred J. Crowle, Jerry L. Brown – 1 July 1984 – We have used crossed Immunoelectrophoresis to identify and establish the relative amounts of serum proteins secreted by a differentiated cell line (Fao) derived from a Reuber H35 rat hepatoma. Our results show that these cells secrete at least 15 plasma proteins. Ten of these: albumin, α1‐antitrypsin, α1‐lipoprotein, α1‐macroglobulin, α1‐antichymotrypsin, GC‐globulin (transcalciferin), fibronectin, hemopexin, transferrin and the C3 component of complement have been identified.

William W. Faloon – 1 July 1984

Gilles Duhamel, Bertrand Nalpas, Sonia Goldstein, P. Michel Laplaud, Pierre Berthelot, M. John Chapman – 1 July 1984 – In the present study, we report on alterations in plasma lipid, lipoprotein and apolipoprotein patterns in three separate populations of alcoholic patients, one without liver damage (Group I), a second presenting steatosis or mild alcoholic hepatitis or both (Group II) and a third with alcoholic cirrhosis (Group III), using a healthy, normolipidemic, nonalcoholic group as controls (Group C).

Albert J. Czaja, Gary L. Davis, Jurgen Ludwig, Howard F. Taswell – 1 July 1984 – To assess the frequency and significance of complete resolution of inflammatory activity following corticosteroid therapy, 115 patients with severe HBsAg‐negative chronic active hepatitis were followed regularly for 84 ± 5 months. Of 83 patients eligible to revert to normal liver tissue, 18 did so after 56 ± 8 months. Five of the 18 relapsed after treatment withdrawal.