Complete Resolution of Inflammatory Activity Following Corticosteroid Treatment of HBsAg‐Negative Chronic Active Hepatitis

Albert J. Czaja, Gary L. Davis, Jurgen Ludwig, Howard F. Taswell – 1 July 1984 – To assess the frequency and significance of complete resolution of inflammatory activity following corticosteroid therapy, 115 patients with severe HBsAg‐negative chronic active hepatitis were followed regularly for 84 ± 5 months. Of 83 patients eligible to revert to normal liver tissue, 18 did so after 56 ± 8 months. Five of the 18 relapsed after treatment withdrawal.

Plasma Lipoprotein and Apolipoprotein Profile in Alcoholic Patients with and without Liver Disease: On the Relative Roles of Alcohol and Liver Injury

Gilles Duhamel, Bertrand Nalpas, Sonia Goldstein, P. Michel Laplaud, Pierre Berthelot, M. John Chapman – 1 July 1984 – In the present study, we report on alterations in plasma lipid, lipoprotein and apolipoprotein patterns in three separate populations of alcoholic patients, one without liver damage (Group I), a second presenting steatosis or mild alcoholic hepatitis or both (Group II) and a third with alcoholic cirrhosis (Group III), using a healthy, normolipidemic, nonalcoholic group as controls (Group C).

Studies on the Secretion of Serum Proteins from Rat Hepatoma Cells

Ardythe A. Mccracken, Merrill Emmett, Alfred J. Crowle, Jerry L. Brown – 1 July 1984 – We have used crossed Immunoelectrophoresis to identify and establish the relative amounts of serum proteins secreted by a differentiated cell line (Fao) derived from a Reuber H35 rat hepatoma. Our results show that these cells secrete at least 15 plasma proteins. Ten of these: albumin, α1‐antitrypsin, α1‐lipoprotein, α1‐macroglobulin, α1‐antichymotrypsin, GC‐globulin (transcalciferin), fibronectin, hemopexin, transferrin and the C3 component of complement have been identified.

Immunocytochemical Detection of Desmin in Fat‐Storing Cells (Ito Cells)

Yukio Yokoi, Toshihiko Namihisa, Hlroyuki Kuroda, Ikutoshi Komatsu, Akihisa Miyazaki, Sumio Watanabe, Koh Usui – 1 July 1984 – Desmin is a smooth muscle protein consisting of intermediate filaments. It is also present in other cell types. We obtained desmin antibodies from New Zealand white rabbits which were immunized with desmin following its extraction from chicken gizzard smooth muscle. By immunocytochemical methods, the antibody stained the Z‐line of rat skeletal myofibrils and produced only one band with chicken gizzard desmin by immunoblotting.

Pigment Gallstones of the Common Bile Duct in Infancy

Bruno Descos, Olivier Bernard, Francis Brunelle, Jacques Valayer, Delphine Feldmann, Michelle Hadchouel, Daniel Alagille – 1 July 1984 – Ten infants of less than 6 months of age presented with cholestatic jaundice and gallstones. Jaundice occurred after a lag period, and sepsis was present in three children. Ultrasound examination showed dilatation of intrahepatic and extrahepatic bile ducts in eight patients and detected cholelithiasis in three.

The Window Period Between Hepatitis B e Antigen and Antibody in Chronic Type B Hepatitis

Yun‐Fan Liaw, Miau‐Ju Huang, Chia‐Ming Chu, I‐Shyan Sheen, Deng‐Yn Lin – 1 July 1984 – To examine the period between disappearance of hepatitis B e antigen (HBeAg) and appearance of anti‐HBe, 48 patients with clinicopathologically verified chronic B hepatitis were followed every 1 to 3 months after HBeAg clearance. Sera were tested by radioimmunoassay for HBeAg and anti‐HBe. Anti‐HBe appeared in days to years, mostly (78.7%) within 1 year, after disappearance of HBeAg. Only 40.5% of patients had an “e‐window” shorter than 1 month.

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