Liver Ultrastructure in Mitochondrial Urea Cycle Enzyme Deficiencies and Comparison with Reye's Syndrome

Patricia S. Latham, Douglas R. Labrecque, John W. Mcreynolds, Gerald Klatskin – 1 May 1984 – The liver ultrastructural findings in two girls with partial carbamyl phosphate synthetase I (CPS) deficiency and their heterozygote parents and two siblings with ornithine transcarbamylase (OTC) deficiency are described. Liver ultrastructure in the four patients with inherited deficiences of urea cycle enzymes showed minimal alterations with essentially normal mitochondria when biopsy was performed during periods of good control of their hyperammonemia.

Comparison of Intravenous Somatostatin and Vasopressin Infusions in Treatment of Acute Variceal Hemorrhage

David Kravetz, Jaime Bosch, Josep Terés, Jordi Bruix, Antoni Rimola, Juan Rodés – 1 May 1984 – The present trial compared the effectiveness and complications of intravenous somatostatin and vasopressin in treatment of variceal bleeding. Sixty‐one cirrhotic patients with endoscopically proven active variceal bleeding were included. Both drugs were given as continuous intravenous infusions for 48 hr. Thirty patients received somatostatin (250 #ig per hr after a bolus of 50 ng) and 31 vasopressin (0.4 units per min).

Hepatocytes of Zones 1 and 3 Conjugate Sulfobromophthalein with Glutathione

Elinor H. Chen, Jorge J. Gumucio, Norman H. Ho, Deborah L. Gumucio – 1 May 1984 – The capacity of hepatocytes of Zones 1 and 3 of the liver acinus to conjugate sulfobromophthalein (BSP) with glutathione and to secrete the conjugate into bile was studied. BSP was infused into the in situ perfused rat liver in concentrations of 0.01 and 0.05 mM. Perfusions were performed either in the portal to hepatic vein direction (forward perfusion) or in the hepatic vein to portal vein direction (retrograde perfusion).

Measurement of Azygos Venous Blood Flow by a Continuous Thermal Dilution Technique: An Index of Blood Flow Through Gastroesophageal Collaterals in Cirrhosis

Jaime Bosch, Roberto J. Groszmann – 1 May 1984 – A method to quantitate blood flow through the gastroesophageal collaterals in portal hypertensive patients was developed. Since gastroesophageal collaterals drain into the azygos system, it is postulated that measurement of blood flow in the azygos vein should provide a quantitative measurement of gastroesophageal collateral blood flow changes in portal hypertensive patients. Azygos blood flow was measured using a double thermodilution catheter directed under fluoroscopy to the azygos vein. Ten patients with alcoholic cirrhosis were studied.

Prognostic Value of Child‐Turcotte Criteria in Medically Treated Cirrhosis

Erik Christensen, Poul Schlichting, Lis Fauerholdt, Christian Gluud, Per Kragh Andersen, Erik Juhl, Hemming Poulsen, Niels Tygstrup, The Copenhagen Study Group For Liver Diseases – 1 May 1984 – The Child‐Turcotte criteria (CTC) (based on serum bilirubin and albumin, ascites, neurological disorder and nutrition) are established prognostic factors in patients with cirrhosis having portacaval shunt surgery. The objective of this study was to evaluate the prognostic value of CTC in conservatively treated cirrhosis.

Nuclear Particles of Non‐A, Non‐B Type in Healthy Volunteers and Patients with Hepatitis B

Hanspeter Spichtin, Fred Gudat, Hans Berthold, Gunthild Krey, Martin Schmid, Mauro Pirovino, Josef Altorfer, Georg Stalder, Gerald Eder, Leonardo Bianchi – 1 May 1984 – In an electron microscopic study, nuclear aggregates of virus‐like spherical and tubular particles measuring 20 to 29 nm in diameter were found in 5 of 7 clinically healthy volunteers with normal liver histology, 6 of 10 patients with hepatitis B and 17 of 18 patients with hepatitis non‐A, non‐B. The incidence of hepatocytes containing nuclear particles was approximately 0.5 to 2% in all three groups.

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