Oscar W. Portman, Manfred Alexander, Charles E. Cornelius, Jayanta Roy Chowdhury, Namita Roy Chowdhury, Irwin M. Arias – 1 May 1984 – Bolivian squirrel monkeys (Saimiri sciureus) have fasting unconjugated hyperbilirubinemia (males: 2.0 ± 0.14; females: 3.0 ± 0.26 mg per dl) which resembles that of humans with Gilbert's syndrome. Closely related Brazilian squirrel monkeys have fasting levels (males: 0.29 ± 0.045; females: 0.36 ± 0.073 mg per dl) similar to normal people. The purpose of this study was to identify the underlying mechanisms and the nutritional factors involved.

1 May 1984

1 May 1984

Peter Ferenci, S.Chris Pappas, Peter J. Munson, Ken Henson, E. Anthony Jones – 1 March 1984 – It has previously been shown in an animal model of hepatic encephalopathy (HE) that the number of receptors for the inhibitory neurotransmitter, γ‐aminobutyric acid (GABA), increases and that the number of receptors for the excitatory neurotransmitter, glutamate, decreases.

Hiroshi Murakami, Junsuke Kuriki, Shinichi Kakumu, Kazuhiko Fukui, Nobuo Sakamoto – 1 March 1984 – Hybrid cell lines which secreted antibodies to liver‐specific membrane lipoprotein (LSP) were obtained by immunizing SMA and BALB/c mice with human LSP and fusing their splenocytes with the myeloma cell line P 3‐NSI/l‐Ag 4‐l.

John Gollan, Antony Mcdonagh – 1 March 1984

Charles S. Davidson – 1 March 1984

1 March 1984

Gerald Y. Minuk, John Vergalla, Peter Ferenci, E. Anthony Jones – 1 March 1984 – γ‐Aminobutyric acid (GABA) is a potent inhibitory neurotransmitter which is synthesized by the enteric bacterial flora and delivered into portal venous blood. To determine whether the liver is likely to play an important role in regulating serum GABA levels, the uptake and metabolism of [3H]GABA by three populations of cells isolated from rat liver were studied. GABA was specifically taken up by hepatocytes but not by endothelial or Kupffer cells.

Gary C. Kanel, Robert L. Peters – 1 March 1984 – The hepatorenal syndrome, a primary cause of death from acute and chronic liver disease, consists of a functional renal failure whereby examination of the kidney has previously shown no distinct or specific morphologic change. We describe an unusual renal lesion consisting of the reflux of proximal convoluted tubular epithelium into Bowman's space. An autopsy series shows this glomerular change to be present in 71.4% of cases with the hepatorenal syndrome, while only present in 0 to 27.3% in other autopsy categories (p < 0.001).