Comparison of Dietary Protein with an Oral, Branched Chain‐Enriched Amino Acid Supplement in Chronic Portal‐Systemic Encephalopathy: A Randomized Controlled Trial

Douglas Horst, Norman D. Grace, Harold O. Conn, Eugene Schiff, Steven Schenker, Alfredo Viteri, David Law, Colin E. Atterbury – 1 March 1984 – A randomized study was conducted in 37 hospitalized patients at six cooperating hospitals in which protein‐intolerant cirrhotic patients were fed increasing amounts of either dietary protein or a branched‐chain enriched amino acid solution (BCAA) until they attained an intake of 80 gm protein per day or equivalent or until they developed stage 2 encephalopathy.

Metabolic Bone Disease in Alcoholic Cirrhosis: A Comparison of the Effect of Vitamin D2 25‐Hydroxyvitamin D, or Supportive Treatment

Sohrab A. Mobarhan, Robert M. Russell, Robert R. Recker, David B. Posner, Frank L. Iber, Pamela Miller – 1 March 1984 – In a study of 56 alcoholics with liver cirrhosis, 18 (32%) had decreased bone density and low levels of serum 25‐hydroxyvitamin D (25‐OH‐D) (<20 ng per ml).

Frequency of Papillary Dysfunction Among Cholecystectomized Patients

Simon Bar‐Meir, Zamir Halpern, Eithan Bardan, Tuvia Gilat – 1 March 1984 – Four hundred and fifty‐four consecutive patients who had had their gallbladder removed were interviewed to determine the presence of upper abdominal pain, increased serum alkaline phosphatase and/or serum amylase activity. Patients with unexplained upper abdominal pain and/or enzyme abnormalities were offered endoscopic retrograde cholangiopancreatography (ERCP) and manometric evaluations.

Induction of Taurocholate Release from Isolated Rat Hepatocytes in Suspension by α‐Adrenergie Agents and Vasopressin: Implications for Control of Bile Salt Secretion

David A. Gewirtz, Joyce K. Randolph, I. David Goldman – 1 March 1984 – Hepatocytes incubated with 25 μM. [3H]taurocholate rapidly deplete the extracellular medium of [3H]taurocholate and achieve a steady‐state level of intracellular bile salt within 15 min. Exposure of cells at steady state ith extracellular taurocholate to the catecholamines norepinephrine or epinephrine results in release of 3H from the cells into the incubation medium; the 3H released represents almost exclusively unmetabolized [3H]taurocholate.

Liver Membrane Antibodies Detected by Immunoradiometric Assay in Acute and Chronic Virus‐Induced and Autoimmune Liver Disease

K. H. Wiedmann, T. C. Bartholemew, D. J. C. Brown, Howard C. Thomas – 1 March 1984 – In this study, we describe a radioimmunoassay to detect liver membrane binding antibodies. The assay was designed to exclude binding of aggregated IgG or immune complexes to Fc 7 receptors of hepatocytes. When this assay was applied to sera from 142 patients, antibodies were found in highest titer in patients with autoimmune chronic active hepatitis, rarely in patients with hepatitis B virus‐induced chronic active liver disease, and in 32% of patients with primary biliary cirrhosis.

Biochemical and Morphological Alterations of Baboon Hepatic Mitochondria After Chronic Ethanol Consumption

Masao Arai, Maria A. Leo, Masayuki Nakano, Ellen R. Gordon, Charles S. Lieber – 1 March 1984 – Baboons fed ethanol (50% of total calories) chronically develop ultrastructural alterations of hepatic mitochondria. To determine whether mitochondrial functions are also altered, mitochondria were isolated from nine baboons fed ethanol chronically and their pair‐fed controls. At the fatty liver stage, ADP‐stimulated respiration was depressed in ethanol‐fed baboons by 59.4% with glutamate, 43.2% with acetaldehyde, 45.1% with succinate and 51.1% with ascorbate as substrates.

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