Reversal of Intrahepatic Cholestasis of Pregnancy in Women after High Dose S‐Adenosyl‐L‐Methionine Administration

Mario Frezza, Gabriele Pozzato, Lucio Chiesa, Giorgio Stramentinoli, Carlo Di Padova – 1 March 1984 – Previous investigations have indicated that S‐adenosyl‐L‐methionine (SAMe) leads to reversal of estrogen‐induced bile flow impairment in rats. This randomized, single‐blind clinical trial was performed to determine whether SAMe reverses intrahepatic cholestasis of pregnancy (ICP) which occurs in hypersensitive women associated with increased estrogen levels in late pregnancy.

Franco‐Belgian Cooperative Study of Ursodeoxycholic Acid in the Medical Dissolution of Gallstones: A Double‐Blind, Randomized, Dose‐Response Study, and Comparison with Chenodeoxycholic Acid

Serge Erlinger, Alice Le Go, Jean‐Marc Husson, Johan Fevery – 1 March 1984 – A double‐blind randomized, multicenter study was carried out to determine the efficacy and safety of ursodeoxycholic acid (UDCA) at 4 doses of 2.1 to 16.2 mg‐kg−1 day−1, and chenodeoxycholic acid (CDCA) at the dose of 16.9 mg‐kg−1 ‐day−1, in 197 patients treated for up to 1 year for radiolucent gallstones in functioning (opacified) gallbladders.

Prognostic Value of Total Serum Bilirubin/γ‐Glutamyl Transpeptidase Ratio in Cirrhotic Patients

Thierry Poynard, Othar Zourabichvili, Gerard Hilpert, Sylvie Naveau, Alain Poitrine, Clarisse Benatar, Jean‐Claude Chaput – 1 March 1984 – The aim of this study was to assess the prognostic value of total serum bilirubin (TSB), γ‐glutamyl transpeptidase (GGT) and the TSB/GGT ratio in 129 consecutive cirrhotic patients, and to determine how seven other clinical and biochemical variables affect the prognostic value of these measurements. The Cox model and log rank test were used to compare survival rates at 1 year.

Intestinal Calcium Absorption and Vitamin D Status in Chronic Cholestatic Liver Disease

Jose M. Bengoa, Michael D. Sitrin, Stephen Meredith, Susan E. Kelly, Nikunj Shah, Alfred L. Baker, Irwin H. Rosenberg – 1 March 1984 – Metabolic bone disease is common in patients with cholestatic liver disease. The importance of vitamin D status and calcium malabsorption in the pathogenesis of bone disease in these patients remains undefined. We have measured intestinal calcium absorption in relation to vitamin D status in 14 patients with chronic cholestatic liver disease including 11 with primary biliary cirrhosis.

Frequency of Hyperprolinemia in Alcoholic Liver Cirrhosis: Relationship to Blood Lactate

Spencer Shaw, Theresa M. Worner, Charles S. Lieber – 1 March 1984 – In alcohol‐induced liver injury, hyperprolinemia has been proposed as a marker of fibrogenesis probably secondary to hyperlactacidemia. However, some studies of plasma proline in alcoholics with cirrhosis have reported normal rather than increased levels.

Ultrastructural Studies of Fibroblasts Transfected with Hepatitis B Virus DNA

Naoto Aoki, Michael A. Gerber, Swan N. Thung, Mei‐Ling Chen, Judith K. Christman, Peter M. Price, Christos S. Flordellis, George Acs – 1 January 1984 – Cultured 3T3 mouse fibroblasts transfected with cloned hepatitis B virus genome and DNA coding for methotrexate‐resistant dihydrofolate reductase, produce and secrete significant amounts of hepatitis B surface antigen (HBsAg).

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