Albert J. Czaja, Gary L. Davis, Jurgen Ludwig, Howard F. Taswell – 1 July 1984 – To assess the frequency and significance of complete resolution of inflammatory activity following corticosteroid therapy, 115 patients with severe HBsAg‐negative chronic active hepatitis were followed regularly for 84 ± 5 months. Of 83 patients eligible to revert to normal liver tissue, 18 did so after 56 ± 8 months. Five of the 18 relapsed after treatment withdrawal.

1 July 1984

Maria H. Sjogren, Stanley M. Lemon, Whan K. Chung, Hee S. Sun, Jay H. Hoofnagle – 1 July 1984 – Primary hepatocellular carc1inoma (PHC) has been linked etiologically to persistent hepatitis B virus (HBV) infections by epidemiologic, serologic and molecular lines of evidence. To evaluate the frequency of IgM antibody to the viral core antigen (IgM anti‐HBc) detected by a highly sensitive radioimmunoassay, we compared 110 Korean patients with PHC to a group of 63 age‐and sex‐matched control patients with other tumors. Results were correlated with those of commercially available HBV assays.

Masao Omata, Osamu Yokosuka, Fumio Imazeki, Yasuhisa Matsuyama, Katsuo Uchiumi, Yoshimi Ito, Junko Mori, Kunio Okuda – 1 July 1984 – Human hepatitis B‐like viruses have been found in several animal species, including Chinese ducks. Sera from Chinese carrier ducks which were positive for duck hepatitis B virus (DHBV) were inoculated in 33 Japanese one‐day‐old ducklings. The same sera were inoculated in four 3‐week‐old ducklings, and three 3‐month‐oId ducks. Ten uninoculated ducklings served as controls.

Ernest Song, Geoffrey M. Dusheiko, Sheila Bowyer, Michael C. Kew – 1 July 1984 – Sera from 106 southern African blacks with hepatocellular carcinoma and hepatitis B surface antigenemia (HBsAg) were tested for hepatitis B viral DNA (HBV‐DNA) activity, HBV‐DNA polymerase concentrations, and HBV e antigen (HBeAg) and antibody (anti‐HBe) to investigate the state of viral replication in these patients.

Pedro Valencia‐Mayoral, James Weber, Ernest Cutz, Vernon D. Edwards, M. James Phillips – 1 July 1984 – Ultrastructural observations on 12 liver biopsies from 10 patients with arteriohepatic dysplasia syndrome (Alagille's syndrome) are reported. The electron microscopic changes in the liver in this condition are different from those seen in other forms of chronic intra‐ and extrahepatic cholestasis. In particular, the bile canalicular and pericanalicular changes classically observed in cholestasis are infrequently seen.

Alton Meister – 1 July 1984

Maurizio Muraca, Roger Leyten, Johan Fevery – 1 July 1984 – Hepatic bilirubin conjugation and excretion were investigated during pregnancy and lactation in the rat. Bilirubin uridine diphosphate‐glucuronyltransferase activity was decreased by 30% in pregnant rats, both when expressed per milligram of protein or as specific activity and per unit of liver weight. Liver size increased during pregnancy, and, as a consequence, total hepatic glucuronyltransferase activity was unchanged.

Irving S. Benjamin, Calvin J. Ryan, Gert H. C. Engelbrecht, John A. H. Campbell, Rosemaryvan Hoorn‐Hickman, Leslie H. Blumgart – 1 July 1984 – Portacaval transposition (PCT) in rats results in a smaller loss of body mass and liver mass than end‐to‐side portacaval shunt (PCS). Detailed studies of liver function, mass and histology were not previously available and have been undertaken in two different strains of growing rat in order to define the value of this model. PCT rats gained weight normally, while only 50% of PCS rats regained their preoperative weight by the tenth week.

Seymour M. Sabesin, Stuart W. Weidman – 1 July 1984