Jean‐Marc Begue, Christiane Guguen‐Guillouzo, Nicole Pasdeloup, Andre Guillouzo – 1 September 1984 – The cytochrome P‐450 content promptly fell in adult rat hepatocytes cultured in conventional conditions whereas no obvious change was detected over a 10‐day period when these cells were co‐cultured with another rat liver epithelial cell type. A concomitant maintenance of the amino‐pyrine N‐demethylase activity and a high aflatoxin B1‐induced cytotoxicity was observed, and addition of phenobarbital to the culture medium produced about a 2‐fold increase in cytochrome P‐450 level.

Alain Frei, Arthur Zimmermann, Kurt Weigand – 1 September 1984 – To evaluate the diagnostic significance of the collagen Type III (Col 1–3) JV‐terminal propeptide of procollagen Type III, with respect to activity and degree of liver fibrosis, Col 1–3 serum concentrations were measured in 111 patients with chronic liver diseases and in 60 patients were correlated with liver histology and morphometry. Col 1–3 was measured by a specific radioimmunoassay. Biopsies were read without knowledge of diagnosis.

Henry W. Kao, Mary Ashcavai, Allan G. Redeker – 1 September 1984 – Hepatitis A IgM antibody (IgM anti‐HAV), detected by commercially available solid‐phase radioimmunoassay, is an accepted marker of acute viral hepatitis A infection. However, persistence of this serological marker far beyond the acute illness and immediate convalescent period has been reported. To determine the persistence of IgM anti‐HAV following clinically manifest acute hepatitis A infection, 59 patients with this diagnosis were followed prospectively until this marker disappeared or persisted for greater than 60 days.

Kurt A. Black, Viravan Virayotha, Thomas R. Tephly – 1 September 1984 – The exhalation of 14CO2 after the administration of [dimethylamino‐14C]aminopyrine to an organism is assumed to reflect the demethylation of aminopyrine by hepatic mixed‐function oxidase activity. The formaldehyde formed as a result of the demethylation of aminopyrine is then sequentially oxidized to formic acid and CO2.

G. Donald Whedon, Alan F. Hofmann – 1 September 1984

Alan F. Hofmann – 1 September 1984

Martin C. Carey – 1 September 1984 – The hydrophilic‐hydrophobic balance of bile salt monomers can be readily quantified by their elution sequence during reverse‐phase high‐performance liquid chromatography. Such studies have demonstrated that subtle variations in bile salt structure have profound effects on the hydrophilic‐hydrophobic balance of this important family of detergent‐like molecules. The common trihydroxy bile salt, cholate, is more hydrophilic than dihydroxy bile salts with alpha‐oriented OH groups.

Norman B. Javitt – 1 September 1984

Georg Karlaganis, Jan SjÖVall – 1 September 1984

Kenneth Holt, Michael Bennett, Mario Chojkier – 1 September 1984 – The mechanisms responsible for the increased hepatic collagen deposition in alcoholic cirrhosis remain unknown. The question of whether ethanol or acetaldehyde has a direct effect on collagen and noncollagen protein production was investigated in human fibroblasts with no detectable activity of alcohol dehydrogenase to distinguish the effects of these metabolites. To eliminate environmental factors, protein production by confluent human skin, fetal and hepatic fibroblasts was studied after three passages.