Robert E. Kane Iii, Lee J. Chen, M. Michael Thaler – 1 November 1984 – We studied the regulation of hepatic bile salt sulfotransferase activity by gonadal hormones and the effect of gonadal hormones on two bile salt sulfotransferase isoenzymes. Bile salt sulfotransferase enzyme activity was three times greater in the female than in the male rats. Oophorectomy significantly decreased bile salt sulfotransferase activity in the female, but orchidectomy had no effect on bile salt sulfotransferase activity in the male.

Dale C. Snover, Richard K. Sibley, Deborah K. Freese, Harvey L. Sharp, Joseph R. Bloomer, John S. Najarian, Nancy L. Ascher – 1 November 1984 – The histopathological features of orthotopic liver transplants were evaluated in 63 serial biopsy specimens from 17 patients. Biopsies were taken at the time of insertion of the liver (six biopsies), at the time of development of liver function abnormalities (11 biopsies) and as follow‐up to previously abnormal biopsies (46 biopsies).

Charles S. Lieber – 1 November 1984

Alan M. Leichtner, Monty Krieger, Alan L. Schwartz – 1 November 1984 – Low density lipoprotein (LDL) processing was investigated in a human hepatoma‐derived cell line, Hep G2. Hep G2 cells bound, internalized and degraded LDL via a saturable, high affinity (Kd ∼ 2 x 10−8M) pathway similar to that present in other mammalian cells. Although 80% of the uptake and degradation of 125I‐LDL was inhibited by 40‐fold excess native LDL, the same concentration of methylated LDL, which cannot bind to LDL receptors, had virtually no effect on processing.

Antonio Ponzetto, Leonard B. Seeff, Zelma Buskell‐Bales, Kamal G. Ishak, Jay H. Hoofnagle, Hyman J. Zimmerman, Robert H. Purcell, John L. Gerin – 1 November 1984 – Hepatitis B virus and hepatitis delta virus co‐infection in drug addicts has been well described in Europe, the latter agent appearing to have been introduced there in the mid‐1970's. Currently, similar data are scanty among United States addicts.

Hannu Väänänen, Mikko Salaspuro, Kai Lindros – 1 September 1984 – Periportal (pp) and perivenous (pv) hepatocyte populations were separated using a two‐diree‐tional closed perfusion technique with selective addition of collagenase either to direct or retrograde perfusions (Vaananen, H. et al., Liver 1983; 3:131). The activity of GPT in hepatocytes from the pp‐area was 1.9 times higher than in cells from the pv‐area (p < 0.01).

Kenneth S. Warren – 1 September 1984

BjÖRn Lindman – 1 September 1984 – Multicomponent self‐diffusion studies provide a general picture of amphiphile self‐association. Both micelles and microemulsions based on bile salts show a lower degree of association coopera‐tivity, lower aggregate charge densities and more extensive hydration than corresponding ionic surfactant systems. Effectively bicontinuous isotropic solutions of the microemulsion type are more easily formed by bile salts than by surfactants.

George H. Nancollas – 1 September 1984 – The formation of crystalline components in gallstones is governed by the physical‐chemical factors controlling the crystallizaton of minerals in aqueous systems. The elucidation of the mechanism of these reactions, especially at the low supersaturations of interest in vivo, is facilitated by the use of a constant composition method in which the reactions are studied at supersaturation levels automatically sustained, potentiometrically, during the experiments.

1 September 1984