Richard J. Stock, Eugene V. Cilento, Robert S. McCuskey – 1 January 1989 – Hepatic extraction of solutes depends on microvascular angioarchitecture, hemodynamics and solute concentrations. These factors may contribute to the heterogeneity observed in solute transport and uptake in the hepatic lobules. However, predictions of liver extraction based on black‐box models require assumptions about these factors and the microvascular transport mechanisms involved. Consequently, the purpose of this study was to investigate solute transport and uptake by hepatocytes.

Yasuo Yamaguchi, R. Randal Bollinger, Eliana Defaria, Barry Landis, Steven Quarfordt – 1 January 1989 – A technique is described to remove the entire liver in a single stage with preservation of intestinal absorptive function. An inverted V‐shape polyethylene cannula, either heparin bonded or silicon coated, was inserted into the portal vein and inferior vena cava to maintain venous return from the splanchnic and lower caval regions of the anhepatic rat.

Peter P. Anthony – 1 January 1989 – Nine adult white men ranging in age from 27 to 76 (mean, 55 years) were treated for primary hepatic lymphoma between 1972 and 1986 at the Memorial Sloan‐Kettering Cancer Center. Six patients presented with right upper quadrant or epigastric pain or discomfort, and three patients complained of fatigue and lethargy. Fever and night sweats were evident in two, and two patients had lost weight. One patient was asymptomatic; the liver mass was detected during the work‐up for cancer of the prostate.

Hans‐Jörg Burger, Rolf Gebhardt, Claus Mayer, Dieter Mecke – 1 January 1989 – Periportal and perivenous hepatocytes were isolated from rat liver by digitonin/collagenase perfusion for investigating the acinar heterogeneity of amino acid transport activities related to glutamine and ammonia metabolism.

Kenneth W. Warren – 1 January 1989

David H. Van Thiel, Judith S. Gavaler – 1 January 1989 – In elderly males hormonal changes occur that are believed to cause benign prostatic hyperplasia (BPH). These are decreased testosterone production, an increased testosterone SHBG and a slightly increased estradiol production. Liver cirrhosis in males causes similar endocrine changes. We carried out a post mortem study evaluating the prostates of 51 men who died with liver cirrhosis compared with a similar group without any hepatic disease.

Michael C. Kew, Ann McKnight, John Hodkinson, Stanley Bukofzer, Jan D. Esser – 1 January 1989 – Membranous obstruction of the inferior vena cava has been incriminated as a risk factor for hepatocellular carcinoma in South African Blacks and in Japanese. However, the frequency with which this anomaly is found in patients with hepatocellular carcinoma, and hence its numerical importance as an etiological association of the tumor, has not been ascertained.

Antoine Hadengue, Richard Moreau, Raimondo Cerini, Abraham Koshy, Samuel S. Lee, Didier Lebrec – 1 January 1989 – Drugs reported to reduce portal pressure through different mechanisms were combined in the hope of either additive portal hypotensive effects in “responders,” or inducing a portal hypotensive effect in “nonresponders” to the initial drug. Seven patients with alcoholic cirrhosis received verapamil, 10 mg i.v., and, 60 min later, ketanserin, 5 mg i.v.

Peter Schauder – 1 November 1988 – The effects of branched‐chain α‐ketoacids on flux through and activity state of the branched‐chain α‐ketoacid dehydrogenase complex were studied in hepatocytes prepared from chow‐fed, starved, and low‐protein‐diet‐fed rats. Very low concentrations of α‐ketoisocaproate caused a dramatic stimulation (50% activation at 20 μM) of α‐ketoisovalerate decarboxylation in hepatocytes from low‐protein‐fed rats. α‐Keto‐β‐methylvalerate was also effective, but less so than α‐ketoisocaproate.

Yolanta Kruszynska, Nicholas Williams, Michael Perry, Philip Home – 1 November 1988 – We have examined the hypothesis that insulin insensitivity in hepatic cirrhosis is related to abnormalities of glycogen deposition and skeletal muscle enzyme activities. Otherwise well patients with biopsy‐proven hepatic cirrhosis secondary to previous excess alcohol intake were studied.