Donald M. Small, Donna J. Cabral, David P. Cistola, John S. Parks, James A. Hamilton – 1 September 1984 – The ionization behavior of carboxylic acids including aliphatic chain fatty acids and bile acids in solutions, micelles, membranes and proteins is of considerable biological interest. The 13C nuclear magnetic resonance chemical shift of carboxyl carbon of a variety of acids has been shown to be a linear function of the state of ionization of the carboxyl group.

Edward W. Moore – 1 September 1984 – Calcium is present in all pigment gallstones as a salt of one or more of the anions in bile which are most readily precipitable by calcium: (i) carbonate; (ii) bilirubinate; (iii) phosphate, and (iv) “palmitate”. We term these “calcium‐sensitive” anions.

1 September 1984

Ernest Seidman, Andrée M. Weber, Claude L. Morin, Roméo Ethier, Jacques B. Lamarche, Ara J. Guerguérian, Guy Geoffroy, Claude C. Roy – 1 September 1984 – A child with cryptogenic cirrhosis underwent a third session of elective sclerotherapy. Endoscopic therapy consisted of intravascular injection of ethanolamine oleate in varices newly developed at the midesophagus level. Irreversible paraplegia was documented within 8 hr postoperatively. Two years later she eventually died from gastrointestinal bleeding.

Bertrand Nalpas, Anne Vassault, Alain Le Guillou, Bruno Lesgourgues, Nicolas Ferry, Bernard Lacour, Pierre Berthelot – 1 September 1984 – Serum activity of the mitochondrial isoenzyme of aspartate aminotransferase (mAST) was measured with an immunological method in 74 subjects. Fourty‐six were chronic alcoholics with (30) or without (16) obvious alcoholic liver disease; 28 were nonalcoholic controls among whom 14 had acute or chronic viral hepatitis, the remaining 14 being healthy individuals.

Claes Söderlund, Lars Backman, Rolf Erwald, Lennart Forsgren, Olle Marions, Karl‐Ludvig Wiechel – 1 September 1984 – A prospective series of 26 patients with portal hypertension and recent bleeding from esophageal varices was investigated with percutaneous transhepatic selective portography (PTP). PTP was performed immediately prior to and, in 23 patients, just after the initial endoscopic injection sclerotherapy (ST) session to study the acute effects of ST on the mediastinal portal‐systemic collaterals.

Michael S. Kressner, Richard J. Stockert, Anatol G. Morell, Irmin Sternlieb – 1 September 1984 – We tested the hypothesis that the copper present in bile‐the major route of elimination of the metal from the body‐is derived exclusively from hepatocytes by administering radiocopper (84Cu or 67Cu)‐labeled ionic Cu, desialylated (AsCPN) or intact human ceruloplasmin (CPN), intravenously, to rats with cannulated bile ducts. The rates of appearance and the total amounts of radiolabeled isotope recovered in bile were measured.

Edna Ben‐Porath, Jack Wands, Mignon Gruia, Kurt Isselbacher – 1 September 1984 – We assessed the significance of the enhanced detection by monoclonal radioimmunoassay (M‐RIA) of HBsAg in serum of patients with hepatitis B virus (HBV) infection. In acute HBV infection, the M‐RIA detected HBsAg in the blood for a far longer period of time than previously recognized. In some patients, the “window phase” of HBV infection (defined as the presence of anti‐HBc and the lack of detectable HBsAg and anti‐HBs) was shortened or completely eliminated.

Padmanabhan Balaram – 1 September 1984

William I. Higuchi – 1 September 1984 – The purpose of this paper is to review the past and current in vitro studies aimed at understanding the mechanisms of cholesterol gallstone dissolution in bile. As is pointed out, there has been considerable progress in this area during the past 15 years with regard to the physical chemistry of the dissolution process.