Leslie Zieve, Michael Shekleton, Carolyn Lyftogt, Kay Draves – 1 January 1985 – Four injections of subcoma doses of ammonium acetate, octanoic acid or dimethyl disulfide during the first 24 hr after two‐lobe hepatectomy in normal rats markedly depressed DNA synthesis as reflected by liver thymidine kinase activity or the incorporation of tritiated thymidine into hepatic DNA. Recovery from the depressant effects of the three toxins took 16 to 28 hr.

Richard J. Kroeger, Roberto J. Groszmann – 1 January 1985 – We have recently shown that maintenance of portal hypertension in rats is highly dependent on high portal blood flow. This study attempts to determine whether portal hypertension, induced in the rat by partial constriction of the portal vein, can be reduced by lowering portal blood flow with a beta blocking agent.

David J. Greenblatt – 1 January 1985

Gloria E. McNeil, Thomas S. Chen, Carroll M. Leevy – 1 January 1985 – Investigations were undertaken to determine effectiveness of 16,16‐dimethyl prostaglandin E2 (dmPGE2) in overcoming the suppressive effects of ethanol and/or indomethacin on hepatic DNA synthesis. Adult litter mate Sprague‐Dawley rats were subjected to sham operation or partial hepatectomy. Immediately after partial hepatectomy, and at 8‐hr intervals for 24 hr, the rats were given: (a) ethanol with and without dmPGE2 or (b) indomethacin with and without ethanol and/or dmPGE2.

George Wolf – 1 January 1985

James W. Kesterson, G. Richard Granneman, Joseph M. Machinist – 1 November 1984 – Valproic acid (VPA), its unsaturated metabolites and pent‐4‐enoate (4‐PA) were studied for potential hepatotoxicity in rats. 4‐PA, 4‐en‐VPA and 2,4‐dien‐VPA were potent inducers of microvesicular steatosis in young rats. Microvesicular steatosis induced by the 4‐en‐VPA was accompanied by ultrastructural changes characterized by myeloid bodies, lipid vacuoles and mitochondrial abnormalities. Myeloid bodies and lipid vacuoles were seen to a lesser extent in 2,4‐dien‐VPA and 4‐PA‐treated rats.

Francesco B. Bianchi, Graziella Biagini, Giorgio Ballardini, Giovanna Cenacchi, Augusto Faccani, Emilio Pisi, Renzo Laschi, Lance Liotta, Spiridione Garbisa – 1 November 1984 – The immunohistologic distribution of fibronectin, laminin, type IV collagen and whole basement membrane was evaluated in liver biopsies from patients with chronic active liver disease. Fibronectin was consistently increased in the areas of piecemeal necrosis, portal tracts and fibrous septa. Laminin was not detected in normal liver parenchyma.

Mark I. Avigan, Kamal G. Ishak, Richard E. Gregg, Jay H. Hoofnagle – 1 November 1984 – Liver tissue of a newly diagnosed 30‐year‐old patient with abetalipoproteinemia was studied by light and electron microscopy. Despite accumulation of large quantities of lipid droplets in hepatocytes, the lobular architecture remained intact, and there was no fibrosis. Acanthocytes were readily identified in sinusoids by scanning electron microscopy. Profiles of rough endoplasmic reticulum, smooth endoplasmic reticulum and Golgi apparatus appeared normal by transmission electron microscopy.

William V. Mcdermott – 1 November 1984

1 November 1984