Richard B. Jennett, Michael F. Sorrell, Abbas Saffari‐fard, James L. Ockner, Dean J. Tuma – 1 January 1989 – Hepatic ethanol oxidation generates the reactive intermediate acetaldehyde, which binds to proteins. Previous work, using bovine brain tubulin as a model protein, has shown that acetaldehyde preferentially formed stable adducts on the α‐chain of the heterodimeric molecule. This binding resulted in functional impairment of the tubulin/microtubule system as evidenced by a decreased ability of adducted tubulin to form microtubules.

Giorgio Hassan, Stefania Stefanini, Anna Maria Bargagli, Francesco Autuori – 1 January 1989 – The incorporation of 3H‐proline in cells of liver biopsy specimens from patients with chronic active liver diseases has been studied by light and electron microscopic autoradiography. The labeled proline is incorporated by hepatocytes of the external rows of the residual liver lobule, by the cells of the proliferating bile ductule and very actively by the plasma cells localized at the boundary between the inflammatory infiltrate and the liver lobule.

Julio Vorobioff, Guadalupe Garcia‐Tsao, Roberto Groszmann, Guillermo Aceves, Eduardo Picabea, Roberto Villavicencio, Jorge Hernandez‐Ortiz – 1 January 1989 – Ketanserin, a 5‐hydroxytryptamine‐2 receptor blocker, has been shown to decrease portal pressure in recent acute hemodynamic studies that have been performed both in experimental animals and portal hypertensive patients. The present study was designed to investigate the effects of chronic oral administration of ketanserin in portal hypertensive patients with cirrhosis.

Richard J. Stock, Eugene V. Cilento, Robert S. McCuskey – 1 January 1989 – Hepatic extraction of solutes depends on microvascular angioarchitecture, hemodynamics and solute concentrations. These factors may contribute to the heterogeneity observed in solute transport and uptake in the hepatic lobules. However, predictions of liver extraction based on black‐box models require assumptions about these factors and the microvascular transport mechanisms involved. Consequently, the purpose of this study was to investigate solute transport and uptake by hepatocytes.

Yasuo Yamaguchi, R. Randal Bollinger, Eliana Defaria, Barry Landis, Steven Quarfordt – 1 January 1989 – A technique is described to remove the entire liver in a single stage with preservation of intestinal absorptive function. An inverted V‐shape polyethylene cannula, either heparin bonded or silicon coated, was inserted into the portal vein and inferior vena cava to maintain venous return from the splanchnic and lower caval regions of the anhepatic rat.

Peter P. Anthony – 1 January 1989 – Nine adult white men ranging in age from 27 to 76 (mean, 55 years) were treated for primary hepatic lymphoma between 1972 and 1986 at the Memorial Sloan‐Kettering Cancer Center. Six patients presented with right upper quadrant or epigastric pain or discomfort, and three patients complained of fatigue and lethargy. Fever and night sweats were evident in two, and two patients had lost weight. One patient was asymptomatic; the liver mass was detected during the work‐up for cancer of the prostate.

Hans‐Jörg Burger, Rolf Gebhardt, Claus Mayer, Dieter Mecke – 1 January 1989 – Periportal and perivenous hepatocytes were isolated from rat liver by digitonin/collagenase perfusion for investigating the acinar heterogeneity of amino acid transport activities related to glutamine and ammonia metabolism.

Kenneth W. Warren – 1 January 1989

David H. Van Thiel, Judith S. Gavaler – 1 January 1989 – In elderly males hormonal changes occur that are believed to cause benign prostatic hyperplasia (BPH). These are decreased testosterone production, an increased testosterone SHBG and a slightly increased estradiol production. Liver cirrhosis in males causes similar endocrine changes. We carried out a post mortem study evaluating the prostates of 51 men who died with liver cirrhosis compared with a similar group without any hepatic disease.

Michael C. Kew, Ann McKnight, John Hodkinson, Stanley Bukofzer, Jan D. Esser – 1 January 1989 – Membranous obstruction of the inferior vena cava has been incriminated as a risk factor for hepatocellular carcinoma in South African Blacks and in Japanese. However, the frequency with which this anomaly is found in patients with hepatocellular carcinoma, and hence its numerical importance as an etiological association of the tumor, has not been ascertained.