The spectrum of complement‐fixing antinuclear antibodies in patients with hepatocellular carcinoma

Kendo Kiyosawa, Richard J. Daemer, Li‐Fang He, Ferruccio Bonino, O. W. Prozesky, Robert H. Purcell – 1 July 1985 – Sera from 230 hepatocellular carcinoma patients were tested for antinuclear antibodies by anticomplement immunofluorescence in 16 types of transformed, diploid or primary cells of human, monkey, chimpanzee or rat origin. As controls, we tested 85 sera from patients with chronic liver diseases, 48 sera from patients with nonhepatic cancers and 164 sera of normal controls.

Endoscopic sclerosis and esophageal balloon tamponade in acute hemorrhage from esophagogastric varices: A prospective controlled randomized trial

Karl‐Joseph Paquet, Hubertus Feussner – 1 July 1985 – A prospective randomized controlled clinical trial was performed in 43 consecutive histologically proved cirrhotic patients with endoscopically proved actively bleeding esophageal varices. Twenty‐two were randomly selected to have esophageal tamponade with the Sengstaken‐Blakemore tube, and 21 were selected to have endoscopic sclerosis of the esophageal wall.

Effects of anesthetic agents on bile pigment excretion in the rat

Glenn R. Gourley, William Mogilevsky, Richard A. Arend, Frank L. Siegel, Gerard B. Odell – 1 July 1985 – Anesthesia‐induced alterations in bilirubin conjugation were studied. Rats were fitted with bile duct and jugular vein catheters while anesthetized with diethyl ether, ketamine or pentobarbital. As anesthesia abated, bile was collected for the next 5 hr and analyzed for flow rate, total bilirubin excretion and bilirubin glucuronide composition. The high‐performance liquid chromatography method used allowed direct analysis of bile without derivatization or extraction.

A carrier‐protein receptor is not a prerequisite for avid hepatic elimination of highly bound compounds: A study of propranolol elimination by the isolated perfused rat liver

D. Brian Jones, Michael S. Ching, Richard A. Smallwood, Denis J. Morgan – 1 July 1985 – The highly efficient hepatic extraction of propranolol by the isolated perfused rat liver does not diminish when albumin binding is increased from 30 to 75%. One possible explanation of this insensitivity of propranolol uptake to changes in albumin binding is the mediation of uptake of bound ligand by an albumin receptor on the hepatocyte as postulated for oleate, taurocholic acid and rose bengal.

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