The Fate of Polymeric and Secretory Immunoglobulin A After Retrograde Infusion into the Common Bile Duct in Rats

Albert L. Jones, Gary T. Hradek, Douglas L. Schmucker, Brian J. Underdown – 1 November 1984 – In the rat, plasma IgA is rapidly endocytosed by hepatocytes and translocated to the bile via a receptor‐mediated vesicular transport system which appears to remain intact even during cholestasis. During the latter phenomenon, there is an accumulation of secretory IgA (sIgA) in plasma. These data suggest that biliary IgA can be regurgitated into the plasma compartment. The present study was designed to determine the location and mechanism(s) by which this might occur.

HLA‐DR Antigens in HBsAg‐Positive Chronic Active Liver Disease with and without Associated Delta Infection

Barbara Forzani, Giovanni C. Actis, Giorgio Verme, Antonio Amoroso, Iolanda Borelli, Emilio S. Curtoni, Maria Grazia Rumi, Antonio Picciotto, Giovanni Marinucci, Maria Antonietta Freni, Mario Rizzetto – 1 November 1984 – The A, B, C and DR locus specificities of the human leukocyte antigens system (HLA) were determined in 45 delta‐positive and 44 delta‐negative Italian patients, all with HBsAg‐positive chronic active liver disease; controls were 526 healthy Italian blood donors matched for age, sex and geographical origin. HLA‐A, B, C gene frequencies were not significantly changed.

In Vivo Interactions Between H2‐Receptor Antagonists and Ethanol Metabolism in Man and in Rats

Helmut K. Seitz, Siegrid Veith, Peter Czygan, Johann Bösche, Bernd Simon, Roland Gugler, Burkhard Kommerell – 1 November 1984 – The influence of a 7‐day medication of either cimetidine (1,000 mg per day) or ranitidine (300 mg per day) on serum ethanol concentrations after a single oral dose of ethanol (0.8 gm per kg body weight) was investigated in a randomized placebo‐controlled study in eight male volunteers. Compared with the placebo, cimetidine but not ranitidine produced a significant increase in both the peak serum ethanol concentration (85.9 ± 3.5 vs.

The Nicotinic Acid Test in Constitutional Conjugated Hyperbilirubinemias and Effects of Corticosteroid

Hideki Ohkubo, Kunio Okuda – 1 November 1984 – The nicotinic acid test was performed in 5 patients with Dubin‐Johnson syndrome, 5 with Rotor syndrome and 13 with Gilbert's syndrome. The increment in serum bilirubin concentration and bilirubin retention 5 hr later differed; the proportion of conjugated bilirubin in the increment of total bilirubin in Dubin‐Johnson and Rotor syndromes was greater than in Gilbert's syndrome. These observations suggest that the nicotinic acid test reflects, in part, impaired biliary excretion of conjugated bilirubin.

Effects of Propranolol on Azygos Venous Blood Flow and Hepatic and Systemic Hemodynamics in Cirrhosis

Jaime Bosch, Ricardo Masti, David Kravetz, Jordi Bruix, Joan Gaya, Joaquin Rigau, Joan Rodes – 1 November 1984 – The effects of propranolol on blood flow through gastroesophageal collaterals and on systemic and hepatic hemodynamies were investigated in 23 cirrhotic patients with portal hypertension. Gastroesophageal collateral blood flow was evaluated by the measurement of azygos venous blood flow by continuous thermal dilution.

Activity and Regulation of Low Density Lipoprotein Receptors in a Human Hepatoblastoma Cell Line

George Y. Wu, Catherine H. Wu, Vincent A. Rifici, Richard J. Stockert – 1 November 1984 – The responsiveness of low density lipoprotein (LDL) binding and uptake was measured in a human hepatoblastoma cell line, Hep G2. These cells exhibited both saturable, high‐affinity and nonsaturable low‐affinity components similar to that described for LDL binding in other mammalian cells. In addition, receptor‐mediated uptake of [125I]LDL was dependent on the presence of Ca++ and required intact lysine residues in LDL as evidenced by abolition of binding following reductive methylation of LDL.

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