Respective roles of hypoxia and halothane metabolism in halothane‐induced liver injury in rats

Hitoshi Hatano, Fumio Nomura, Kunihiko Ohnishi, Toshihiko Iijima, Akira Hayasaka, Shinji Iida, Hirofumi Koen, Kunio Okuda – 1 March 1985 – To evaluate the respective roles of halothane metabolism and hypoxia in rats with halothane hepatotoxicity, experiments were designed with special reference to blood gas. After pretreatment with phenobarbital (80 mg per kg., i.p.) for four consecutive days, rats were exposed to 1.0% halothane under a mildly hypoxic condition (FiO2 = 14%) for 2 hr.

The effects of colchicine and vinblastine on the biliary excretion of carcinoembryonic antigen

Peter Thomas, Paul F. O'Neil, Norman Zamcheck – 1 March 1985 – The biliary output of carcinoembryonic antigen (CEA) in bile fistula rats following treatment with the microtubule poisons vinblastine and colchicine increased 3‐fold over a 4‐hr period. Cytochalasin B and the inactive colchicine derivative lumicolchicine had no effect. These treatments did not effect the rate of CEA clearance from the circulation. Biliary output of low molecular weight fragments from CEA degradation was decreased in the presence of colchicine and vinblastine.

Endocytosis and binding of asialoorosomucoid by hepatocytes from rats with jejunoileal bypass

Nathalie Serbource‐Goguel/Seta, Béatrice Borel, Michèle Dodeur, Pierre Scarmato, Benoit Bourel, Jeanne Feger, Geneviève Durand – 1 March 1985 – Rats with Jejunoileal bypass were used to study the biological activity of the hepatic binding protein. Hepatocytes were prepared 11 weeks after surgical procedure, and presence of asialoo‐rosomucoid in serum has been determined.

The effect of concentration on hepatic transport of exogenous epidermal growth factor

Susan Jo Burwen, Mary E. Barker, Ira S. Goldman, Albert L. Jones – 1 March 1985 – Epidermal growth factor (EGF), taken up by rat liver hepatocytes, is primarily transported to the lysosomes and degraded. However, a small but significant percentage of endocytosed EGF is transported by a nonlysosomal pathway and is secreted intact into bile. There is no information as to the mechanisms that regulate the selection of transport pathway and thereby determine the different metabolic fates for EGF.

Reversal of ethanol and indomethacin‐induced suppression of hepatic DNA synthesis by 16,16‐dimethyl prostaglandin E2

Gloria E. McNeil, Thomas S. Chen, Carroll M. Leevy – 1 January 1985 – Investigations were undertaken to determine effectiveness of 16,16‐dimethyl prostaglandin E2 (dmPGE2) in overcoming the suppressive effects of ethanol and/or indomethacin on hepatic DNA synthesis. Adult litter mate Sprague‐Dawley rats were subjected to sham operation or partial hepatectomy. Immediately after partial hepatectomy, and at 8‐hr intervals for 24 hr, the rats were given: (a) ethanol with and without dmPGE2 or (b) indomethacin with and without ethanol and/or dmPGE2.

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