Arnold N. Cohen, Jaime Kapitulnik, J. Donald Ostrow, Eugene A. Zenone, Cecile Cochrane, Lillian Celic, Heidemarie Cheney – 1 March 1985 – Jaundiced Gunn rats, treated with phenobarbital (60 mg per kg i.p. for 7 to 10 days) showed 25 and 36% decreases in mean plasma bilirubin levels in two experiments (p < 0.01). Kinetic studies with tracer 14C‐bilirubin revealed that there was no change in bilirubin turnover or total pool size due to phenobarbital, but a 49% increase in the hepatic pool and a 27% decrease in the cutaneous pool of bilirubin.

Mario Baraldi, Gary W. Goldstein – 1 March 1985

Bruce A. Runyon, John C. Hoefs – 1 March 1985 – A retrospective analysis of 22 patients whose ascitic fluid had been analyzed prior to the onset of spontaneous bacterial peritonitis, during infection and/or after treatment of peritonitis revealed that neither the ascitic fluid total protein nor the absolute ascitic fluid glucose changed during the infection or after treatment of the infection although the ascitic fluid/serum glucose ratio did decrease (p < 0.001) with infection.

Edward Lebovics, Swan N. Thung, Fenton Schaffner, Paul W. Radensky – 1 March 1985 – We reviewed the clinical data and hepatic histologic findings of 25 patients with the acquired immunodeficiency syndrome who underwent 29 liver biopsies. Our experience indicates that the only hepatic feature characteristic of acquired immunodeficiency syndrome is serologic evidence of exposure to the hepatitis B virus. The most common histologic finding was macrovesicular steatosis.

Karin E. Ljunggren, Manuel E. Patarroyo, Ronald Engle, Robert H. Purcell, John L. Gerin – 1 March 1985 – The prevalences of hepatitis B virus (HBV), hepatitis delta virus and hepatitis A virus infections were studied in two regions of Colombia. In Bogota, 10 of 53 patients with acute hepatitis were HBsAg positive and three of these were hepatitis D antigen positive. Hepatitis A virus was the major cause of acute hepatitis in this group. In 366 healthy controls from Bogota, 1.6% were HBsAg positive and 7.1% had at least one marker of HBV infection.

William G. Rector, Gary C. Kanel, Jorge Rakela, Telfer B. Reynolds – 1 March 1985 – We examined β2‐microglobulin (B2MG) excretion, an index of tubular function, in patients with hepatorenal syndrome, in whom tubular function is generally regarded as normal. Urine B2MG was significantly higher in these patients than in control patients with normal serum creatinine concentration. Patients with high urine B2MG concentration had markedly higher serum bilirubin than did patients with normal values (31 ± 3 vs.

Michael R. Hollingdale – 1 March 1985

Charles S. Davidson, Philip M. Lecompte – 1 March 1985

1 March 1985

Hiroyuki Shiraishi, Harvey J. Alter, Stephen M. Feinstone, Robert H. Purcell – 1 March 1985 – Convalescent phase non‐A, non‐B (NANB) human and chimpanzee sera were utilized in a solid‐phase radioimmunoassay (RIA) in an attempt to identify a specific NANB antigen in human plasma, plasma‐derived pellets and NP‐40 disrupted pellets proven to transmit NANB infection to chimpanzees. RIA reactivity was noted in 5 of 8 pedigreed NANB infectious plasmas, but did not appear to be virus‐specific.