David L. Williams, Edward R. Sherwood, Rose B. McNamee, Ernest L. Jones, Nicholas R. Di Luzio – 1 March 1985 – Glucan, a particulate β‐1,3‐polyglucose immunomodulator, was evaluated for its ability to modify hepatic metastases and survival in mice with reticulum cell sarcoma. Sarcoma M5076 cells were injected subcutaneously (1 × 105 cells) into syngeneic C57BL/6J male mice. On Day 20, histopathological studies indicated the presence of hepatic micrometastases. At this time, glucan (0.45 mg per mouse) or dextrose was administered intravenously.

Hans K. Kley, Wolfgang Stremmel, Claus Niederau, Rainer Hehrmann, Omar Shams, Georg Strohmeyer, Hans L. Krüskemper – 1 March 1985 – Gonadal function in idiopathic hemochromatosis (IHC) was evaluated by comparing clinical features and levels of sex hormones in 10 male patients with IHC (cirrhosis, 4; fibrosis, 6), 6 male patients with alcoholic cirrhosis (AC) and 10 healthy, age‐matched controls. Impotence was present in 9 IHC and all AC patients and was associated with decreased plasma testosterone levels.

Kelvin R. Palmer, William J. Jenkins – 1 March 1985 – Hepatic aldehyde dehydrogenase activity is depressed in alcoholic liver disease and may account for the observation that alcoholics develop high blood acetaldehyde concentrations following ethanol. To determine whether this is a specific defect in alcoholics, aldehyde dehydrogenase was studied in liver tissue obtained from three groups of subjects.

Dale A. Schoeller, Alvin N. Kotake, George H. Lambert, Patricia S. Krager, Alfred L. Baker – 1 March 1985 – The phenacetin breath test (PBT) has been proposed as an alternative to the aminopyrine breath test (ABT) for the assessment of hepatic function. To investigate the clinical utility of the PBT, we compared the PBT with the ABT in 9 healthy subjects and 18 patients with biopsy‐proven liver disease.

Polly Feigl – 1 March 1985

F. Jeffrey Field, John S. Boydstun, Douglas R. Labrecque – 1 January 1985 – Two groups of rats were pair‐fed diets in which 36% of the calories were provided by either ethanol or dextrimaltose. After 60 days on these liquid diets, rats fed ethanol were significantly smaller than control rats fed dextrimaltose. Serum cholesterol levels in ethanol‐fed animals were 20% higher than control rats. Cholestasis was not observed histologically, and serum alkaline phosphatase and bilirubin levels were the same in both groups.

Michael A. Marletta – 1 January 1985

F. Diaz De Rojas, M. Castro Garcia, I. Abaitua Borda, M. Posada De La Paz, J. M. Tabuenca Oliver, J. A. Solis‐Herruzo, G. Castellano, F. Colina, J. D. Morillas, M. T. Muñoz‐Yagüe, J. V. Vidal – 1 January 1985

R. Taylor, R. J. Heine, J. Collins, O. F. W. James, K. G. M. M. Alberti – 1 January 1985 – In vivo insulin sensitivity and adipocyte insulin binding and action were assessed in 16 patients with histologically proven hepatic cirrhosis and 11 age‐, weight‐ and sex‐matched normal control subjects. The cirrhotic group displayed impaired oral glucose tolerance, despite an exaggerated serum immunoreactive insulin response, and in vivo insulin resistance as assessed both by the euglycemic hyperinsulinemic clamp and the glucose‐insulin infusion techniques.

Irmin Sternlieb, Nelson Quintana – 1 January 1985