Julius Erdstein, Steven Wisebord, Shaindel Y. Mishkin, Seymour Mishkin – 1 April 1989 – Morris hepatoma 44, whose growth is sensitive to thyroid hormones and prolactin, contains specific receptors for these hormones. In the present experiments, male Buffalo rats bearing Morris hepatoma 7787 were studied to determine the effects of several sex steroid hormones. Castration 1 week postimplantation inhibited tumor growth relative to controls (‐53%). Replacement with testosterone propionate (1 mg per day s.c.

Bruce F. Scharschmidt, John R. Lake – 1 April 1989 – An impaired sulfoxidation pathway has been implicated in the pathogenesis of chlorpromazine‐induced hepatotoxicity. Since some patients with chronic chlorpromazine‐induced cholestasis may have features of primary biliary cirrhosis, we studied the ability to sulfoxidate the amino acid analogue S‐carboxymethyl‐cysteine in 44 patients with primary biliary cirrhosis and in two control groups—one without liver disease and one with a variety of liver diseases other than primary biliary cirrhosis.

Sergio Sainz, Germán Soriano, Carlos Guarner, Pere Coll, Francisco Vilardell, Bruce A. Runyon – 1 April 1989

Craig J. McClain, Donald A. Cohen – 1 March 1989 – Tumor necrosis factor is a cytokine that mediates many of the biologic actions of endotoxin. Recent studies have shown that tumor necrosis factor administration may cause liver injury and that tumor necrosis factor may mediate the lethality of the hepatotoxin galactosamine. One of the most potent inducers of tumor necrosis factor production is endotoxin.

Tse‐Ling Fong, Evangelos A. Akriviadis, Bruce A. Runyon, Telfer B. Reynolds – 1 March 1989 – The purposes of this study were (a) to measure serially ascitic fluid polymorphonuclear cell response in treated spontaneous bacterial peritonitis and (b) to determine whether an ascitic fluid polymorphonuclear cell count of less than 250 per mm3 on serial paracenteses was a satisfactory endpoint for antibiotic therapy.

Georg A. Mathis, Sandra A. Walls, Paul D'Amico, Thomas F. Gengo, Alphonse E. Sirica – 1 March 1989 – An extensive bile ductular cell hyperplasia with the formation of well‐differentiated bile ductules is the most prominent feature of rat liver at 6 to 15 weeks after bile duct ligation. We have improved our previous cell isolation procedure and are now routinely able to obtain from such livers high yields of viable bile ductular epithelial cells.

Dwain L. Thiele – 1 March 1989

Ernest Urban, Vincent J. Dindzans, David H. Van Thiel – 1 March 1989 – This is a report of six patients with cirrhosis of the liver in whom primary hyperparathyroidism occurred due to a solitary parathyroid adenoma 3 months to 9 years after undergoing emergency portacaval shunt for hemorrhage from esophageal varices. The presenting symptoms in all six patients were weakness and bone pain. Three patients had a bone fracture after insignificant trauma, one and probably two passed kidney stones, and a duodenal ulcer developed in two.

Owen Epstein – 1 March 1989

Richard Moreau, Samuel S. Lee, Antoine Hadengue, Yves Ozier, Christian Sicot, Didier Lebrec – 1 March 1989 – To elucidate the relationship between oxygen transport and uptake in cirrhosis, we studied the effects of three vasoactive drugs that change O2 transport. Systemic hemodynamics, blood gases and lactate concentration were measured in patients with alcoholic cirrhosis before and after intravenous dobutamine, propranolol and nitroglycerin. Nine patients received successively dobutamine and then propranolol. Ten patients received nitroglycerin.