Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet

Hidekazu Tsukamoto, Samuel W. French, Nancy Benson, George Delgado, G. Ananda Rao, Edward C. Larkin, Corey Largman – 1 March 1985 – Blood alcohol levels (BAL) were maintained at high levels (overall mean ± S.D. achieved in 14 alcoholic rats was 216.0 ± 120.1 mg%) in male Wistar rats for 15 to 85 days by continuous intragastric infusion of ethanol and nutritionally defined low fat liquid diet. The ethanol intake was progressively increased from 32% of total calories up to 41.4% in order to maintain high BAL. Pair‐fed animals received isocaloric glucose solution and the liquid diet.

Lack of in vivo activation of the interferon system in HBsAg‐positive chronic active hepatitis

Alain Poitrine, Suzanne Chousterman, Michel Chousterman, Sylvie Naveau, Ming Nguy Thang, Jean‐Claude Chaput – 1 March 1985 – The in vivo activation state of the interferon system was biochemically evaluated in patients with HBsAg‐positive liver disease by assaying the interferon‐induced enzyme, 2′5′‐oligoadenylate synthetase, in peripheral blood mononuclear cells. All patients with chronic active hepatitis had normal levels of enzyme activity.

The effect of cimetidine on hepatic drug elimination in cirrhosis

Donald C. Nelson, George R. Avant, K. Vincent Speeg, Anastacio M. Hoyumpa, Steven Schenker – 1 March 1985 – Both cimetidine therapy and cirrhosis individually interfere with normal elimination of various drugs. Cimetidine is often prescribed in patients with cirrhosis but there is incomplete data on its effect on drug elimination in cirrhotics. The purpose of this study was to address this issue. Eight stable cirrhotics were studied prior to and following 7 days of cimetidine administration, (300 mg orally q.i.d.).

Decreased serum group‐specific component protein levels and complexes with actin in fulminant hepatic necrosis

William M. Lee, David L. Emerson, Phillip A. M. Werner, Philippe Arnaud, Pascal Goldschmidt‐Clermont, Robert M. Galbraith – 1 March 1985 – Monomeric G‐actin has recently been shown to form high‐affinity complexes with group‐specific component protein (Gc), and this process might be expected to occur in vivo when hepatocyte necrosis with release of actin takes place. We therefore measured serum Gc levels and searched for evidence of actin‐containing complexes of Gc in 147 sera from 21 normal subjects and 126 patients with acute and chronic liver diseases.

Pharmacokinetic‐hemodynamic interactions between vasopressin and nitroglycerin: Comparison between intravenous and cutaneous routes of nitrate delivery

Andres T. Blei, Steve Friedman, Jeanne Gottstein, Gary Robertson, Ho‐Leung Fung – 1 March 1985 – Addition of nitroglycerin (NTG) improves the hemodynamic response to vasopressin and may thus be useful in the treatment of gastrointestinal hemorrhage. We studied in the rat the influence of vasopressin on the disposition of a constant intravenous infusion of NTG and the cutaneous absorption of NTG ointment. The effect of NTG on the pharmacokinetics of vasopressin was also defermined. Animals were divided into four groups: control, NTG, vasopressin and vasopressin + NTG.

Temporal relationship between hyperaldosteronism, sodium retention and ascites formation in rats with experimental cirrhosis

Wladimiro Jiménez, Antonio Martinez‐Pardo, Vicente Arroyo, Jordi Bruix, Antoni Rimola, Joan Gaya, Francisca Rivera, Joan Rodés – 1 March 1985 – To investigate the role of aldosterone in sodium retention and ascites in cirrhosis, the urinary sodium excretion, sodium balance and urinary excretion of aldosterone‐18‐glucuronide (UAidV) were serially measured in 11 rats undergoing cirrhosis induction with carbon tetrachloride (CT) and phenobarbital (CT rats) and in 10 control rats which received phenobarbital.

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