Transmission of ground squirrel hepatitis virus to homologous and heterologous hosts

Daniel Trueba, Michael Phelan, John Nelson, Fred Beck, Brian S. Pecha, R. James Brown, Harold E. Varmus, Don Ganem – 1 May 1985 – The infectivity and host range of ground squirrel hepatitis virus (GSHV) have been further examined by animal inoculation experiments. Although carrier squirrel sera usually harbor 109 to 1010 virions per ml as determined by physical measurements, titration of one such serum revealed that squirrel infectivity was lost following dilution of the sample over 106‐fold. Infectivity is markedly reduced by NP40 pretreatment of infected serum.

Biliary and urinary excretion of sulfated, glucuronidated and tetrahydroxylated bile acids in cirrhotic patients

Adolf Stiehl, Richard Raedsch, Gerda Rudolph, Ursula Gundert‐Remy, Martin Senn – 1 May 1985 – In patients with hepatobiliary diseases, considerable amounts of sulfated and glucuronidated bile acids are excreted in urine. Information on the biliary excretion of these compounds is lacking. We used an intestinal perfusion method to determine the biliary excretion of sulfated and glucuronidated bile acids in eight patients with alcoholic cirrhosis and moderately severe cholestasis and compared results with urinary excretion rates.

Portal pressure, presence of gastroesophageal varices and variceal bleeding

Guadalupe Garcia‐Tsao, Roberto J. Groszmann, Rosemarie L. Fisher, Harold O. Conn, Colin E. Atterbury, Morton Glickman – 1 May 1985 – This study was performed to examine the relationships between portal pressure measurements and the presence of esophagogastric varices, the size of varices and the occurrence of hemorrhage from varices in 93 patients with alcoholic cirrhosis, using standardized measurements of portal pressure by hepatic vein catheterization.

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