Acetaminophen‐Induced hepatotoxic congestion in mice
Robin M. Walker, William J. Racz, T. Francis McElligott – 1 March 1985 – Acetaminophen‐induced (750 mg per kg p.o.) hepatotoxicity in mice is characterized by hepatomegaly and massive centrilobular congestion which precede the appearance of necrosis. The vascular changes are correlated with the morphologic features using liver hemoglobin content to quantitate erythrocyte sequestration, and hematocrit measurements and 125I‐albumin injections to determine plasma and blood volume.