Keith D. Lindor, Russell H. Wiesner, Nicholas F. Larusso, Henry A. Homburger – 1 September 1987 – Primary sclerosing cholangitis is a chronic, cholestatic liver disease in which immune mechanisms are thought to play a role in the pathogenesis. We have determined the frequencies and functional phenotypes of autoreactive T‐lymphocytes in peripheral blood specimens from patients with primary sclerosing cholangitis and healthy adults as an indicator of autoreactivity in primary sclerosing cholangitis.

J. Loren Pitcher – 1 September 1987

1 September 1987

Nicholas J. Talley – 1 September 1987

Hans‐Peter Buscher, Mathias Beger, Hella Sauerbier, Wolfgang Gerok – 1 September 1987 – The distribution of [3H]taurocholate between albumin and the lipoproteins of serum of patients with various diseases in which lipoprotein metabolism and/or bile salt concentrations were altered and of healthy control subjects was investigated by means of the density gradient centrifugation method. 1In control sera, bile salts distribute mainly between albumin and high‐density lipoprotein.

Luigi Barbara, Claudia Sama, Antonio Maria Morselli Labate, Francesco Taroni, Anna Giulia Rusticali, Davide Festi, Carlo Sapio, Enrico Roda, Claudio Banterle, Armando Puci, Franco Formentini, Silvia Colasanti, Francesco Nardin – 1 September 1987 – The prevalence of gallstone disease (cholelithiasis and previous cholecystectomy for gallstones) in the population of the town of Sirmione, Italy, examined by ultrasonography, was 6.7% in men and 14.6% in women, ranging from 18 to 65 yr of age (overall prevalence = 11%).

William M. Lee, David L. Emerson, William O. Young, Pascal J. Goldschmidt‐Clermont, David J. Jollow, Robert M. Galbraith – 1 September 1987 – Evidence for increased plasma levels of complexes containing Gc (vitamin D‐binding protein) and cellular actin has been previously reported during fulminant hepatic necrosis in man. In order to study this process in more detail, we produced liver injury in hamsters using increasing doses of acetaminophen, with serial collection of sera for up to 168 hr after acetaminophen injection.

Jean‐Pierre Pignon, Naila C. Bailey, Enrique Baraona, Charles S. Lieber – 1 September 1987 – To study the acute and chronic effects of ethanol on hepatic fatty acid‐binding protein, rats were pair‐fed with liquid diets containing 36% of energy either as ethanol or as additional carbohydrate for 4 to 5 weeks. Animals were killed 90 min after intragastric administration of diets with or without ethanol. Alcohol feeding markedly increased liver triglycerides, with a modest rise in nonesterified fatty acids.

William M. Lee, Lizabeth McLeod, Kylie Martin, David L. Emerson, Robert M. Galbraith – 1 September 1987 – Since antibodies to polyalbumin have been noted to occur in patients with hepatitis or cirrhosis, we investigated sera from 219 patients with a variety of acute and chronic liver diseases with and without HBsAg using an ELISA.

Keun Soo Lee, Hahng Lee, Soo Jee Moon, Kyu Jong Choi, Ki Hong Kim, Chun Won Kim, Wha Soon Chung, Tae Yael Choi – 1 September 1987 – To investigate the efficacy in anti‐HBsAg response with half the recommended adult dose in a standard vaccination schedule or with a full dose in reduced number of vaccination schedule, 201 healthy newborn infants were randomized to receive either 2.5 μg Hevac B vaccine at birth [1, 2 and 14 months in Group I (101)] or 5 μg at birth [2 and 14 months in Group II (100)]. Anti‐HBsAg responses in the two groups were compared.