Geoffrey Dusheiko, Adrian Dibisceglie, Sheila Bowyer, Evelyn Sachs, Marian Ritchie, Barry Schoub, Michael Kew – 1 July 1985 – We have investigated the efficacy of a relatively prolonged course of recombinant leukocyte interferon treatment in 14 chronic HBsAg‐, HBeAg‐, hepatitis B virus DNA‐ and DNA polymerase‐positive carriers. α‐Interferon was administered for 9 weeks. Six of 14 treated carriers have a sustained loss of HBeAg, hepatitis B virus DNA and DNA polymerase. Four subsequently lost HBsAg (28.5%).

Michèle Corbic, Cristina Muñoz, Micheline Dumont, Ghislaine De Couët, Serge Erlinger – 1 July 1985 – The effect of acute metabolic or respiratory acid‐base disturbances on biliary bicarbonate secretion was examined in bile fistula rats. Animals were infused with ursodeoxycholate at a rate that stimulates bicarbonate secretion (1 μmole · min−1 · 100 gm−1), in control conditions and during acute acid‐base disturbances.

Kendo Kiyosawa, Richard J. Daemer, Li‐Fang He, Ferruccio Bonino, O. W. Prozesky, Robert H. Purcell – 1 July 1985 – Sera from 230 hepatocellular carcinoma patients were tested for antinuclear antibodies by anticomplement immunofluorescence in 16 types of transformed, diploid or primary cells of human, monkey, chimpanzee or rat origin. As controls, we tested 85 sera from patients with chronic liver diseases, 48 sera from patients with nonhepatic cancers and 164 sera of normal controls.

Karl‐Joseph Paquet, Hubertus Feussner – 1 July 1985 – A prospective randomized controlled clinical trial was performed in 43 consecutive histologically proved cirrhotic patients with endoscopically proved actively bleeding esophageal varices. Twenty‐two were randomly selected to have esophageal tamponade with the Sengstaken‐Blakemore tube, and 21 were selected to have endoscopic sclerosis of the esophageal wall.

Glenn R. Gourley, William Mogilevsky, Richard A. Arend, Frank L. Siegel, Gerard B. Odell – 1 July 1985 – Anesthesia‐induced alterations in bilirubin conjugation were studied. Rats were fitted with bile duct and jugular vein catheters while anesthetized with diethyl ether, ketamine or pentobarbital. As anesthesia abated, bile was collected for the next 5 hr and analyzed for flow rate, total bilirubin excretion and bilirubin glucuronide composition. The high‐performance liquid chromatography method used allowed direct analysis of bile without derivatization or extraction.

Peter F. Whitington – 1 July 1985

D. Brian Jones, Michael S. Ching, Richard A. Smallwood, Denis J. Morgan – 1 July 1985 – The highly efficient hepatic extraction of propranolol by the isolated perfused rat liver does not diminish when albumin binding is increased from 30 to 75%. One possible explanation of this insensitivity of propranolol uptake to changes in albumin binding is the mediation of uptake of bound ligand by an albumin receptor on the hepatocyte as postulated for oleate, taurocholic acid and rose bengal.

Charles S. Davidson – 1 July 1985

Thierry Poynard, Claude Degott, Didier Lebrec, Hector Orrego, Yedy Israel, Joan E. Blake, L. M. Blendis, R. Britton, Kim Krogsgaard, Christian Gluud, Jens H. Henriksen, Per Christoffersen – 1 July 1985

Charles Davidson – 1 July 1985