Oliver E. Owen – 1 November 1987 – The purpose of this study was to investigate the effect of interleukin 1 (IL 1) on glucocorticoid‐regulated hepatic metabolism. Steroid binding in liver cytosol, plasma glucose, plasma corticoster‐one, and phosphenolpyruvate carboxykinase (PEPCK) activity were assayed in C3H/HeJ mice after IL 1 administration. Mice received 5 pyrogenic U (PU) of rabbit IL 1 i.p. and were sacrificed 4 hr later.

Thomas D. Boyer, Donald A. Vessey – 1 September 1987 – Inhibition of a major hepatic form of human cationic glutathione S‐transferase by bilirubin, biliverdin, indocyanine green and chenodeoxycholic acid was investigated as a function of pH (range = 6.5 to 9.1). Changes in pH had little effect on the extent of inhibition by indocyanine green. However, inhibition by bilirubin, biliverdin and chenodeoxycholic acid was found to be pH‐dependent, with markedly less inhibition at the high values of pH.

Gregory J. Anderson, June W. Halliday, Lawrie W. Powell – 1 September 1987

Joseph Alcorn, Mario Chojkier – 1 September 1987 – Immunolocalization of type III collagen and procollagen in cirrhotic human liver was studied using monoclonal antibody specific for the helical determinant of type III collagen extracted from human placenta. Deparaffinized, trypsin‐treated cirrhotic liver sections from 8 autopsy cases were examined by the unlabeled peroxidase‐antiperoxidase and immunofluorescence techniques.

Peter F. Malet, Y. Peled – 1 September 1987

David J. Schneiderman, David M. Arenson, John P. Cello, William Margaretten, Thomas E. Weber – 1 September 1987 – The spectrum of liver disease in patients with acquired immune deficiency syndrome (AIDS) and the clinical impact of diagnostic percutaneous liver biopsy in this population were evaluated by a retrospective review of hepatic histology, clinical features and laboratory data in 85 patients (26 biopsies, 59 autopsies). Only 1 (3.8%) biopsy and 9 (15%) postmortem livers were histologically normal.

Scott M. Grundy, Sarah C. Kalser – 1 September 1987

Dale C. Snover – 1 September 1987 – The histologic findings in the original liver obtained from 9 liver allograft patients with active B virus hepatitis were compared with 28 post‐transplant pathology specimens. All specimens were studied with the use of light and immunohistochemical microscopy in conjunction with pertinent clinical data. Eight of the 9 patients had chronic active hepatitis B (HB) with cirrhosis, prior to transplant, one of which had coexistent hepatocellular carcinoma. The ninth patient had fulminant hepatic necrosis secondary to acute HB prior to transplantation.

Harold O. Conn, Abby Van Voorhees, Sidney N. Klaus – 1 September 1987 – Although paraneoplastic phenomena occur frequently in patients with hepatocellular carcinoma, cutaneous changes have rarely been reported. During the past two years, ten South African blacks with hepatocellular carcinoma and pityriasis rotunda have been seen in a single hospital. The rash affected the trunk, especially the lower back and buttocks. The lesions ranged in size from 1.5 to 25 cm and were always multiple.

Kunio Okuda – 1 September 1987 – A total of 105 cases of fulminant hepatitis sen during the period fom January 1979 to December 1983 and filed by the pediatric services of major hospitals throughout Japan with the diagnostic criteria set by the 12th Inuyama Liver Symposium were analyzed. The male:Female atio was 2:1. Fifty‐six per cent of he cases werre younge than 2 years and 29.5% were thought to be due to hepaitis B infection. The majority of B‐type fulminant heptitis cases younger than 6 months not related to blood transfusion had been born to HBeAg‐negative caie mohers.