Peter L. M. Jansen, Wilbert H. Peters, Wouter H. Lamers – 1 July 1985 – A mutant rat strain is described with autosomal recessive conjugated hyperbilirubinemia. Transport of conjugated bilirubin and tetrabromosulfophthalein from liver to bile is severely impaired whereas uptake of organic anions from plasma to liver is normal. During the first 10 days of life, serum bilirubin levels are 147 ± 11 μmoles per liter with 68.7% diconjugates and 27.9% monoconjugates. In adult rats, serum bilirubin is 33 ± 8 μmoles per liter with 81.8% diconjugates and 12.1% monoconjugates vs.

Stephanos J. Hadziyannis, Morris Sherman, Harvey M. Lieberman, David A. Shafritz – 1 July 1985 – Delta antigen is currently thought to reflect superinfection of the liver with a defective RNA virus (delta agent), requiring helper function from hepatitis B virus for its replication.

H. Dirk Sostman, John C. Gore, M. Wayne Flye, G. Allan Johnson, Robert J. Herfkens – 1 July 1985 – We studied the proton T1 and T2, water and lipid content of regenerating rat liver from 1 to 7 days after 70% hepatectomy. Liver from normal and sham‐operated animals and splenic tissue from all animals were studied as controls. In vivo proton spectroscopy and imaging of liver was performed in a separate group of control and posthepatectomy rats. The T2 of regenerating liver, but not of sham or normal control liver, was prolonged.

K. Robert McIntire – 1 May 1985

John B. Rogers – 1 May 1985

J. Fred Dice – 1 May 1985 – The age‐associated decjline in function of several organs, including the liver, may be caused by mechanisms operating on the cellular level. Fibroblasts and several other cell types derived from normal individuals have limited lifespans in culture, and several abnormalities described for senescent cultured fibroblasts also apply to hepatocytes and other cell types obtained from aged organisms.

Eugene R. Schiff, Hector Serrano – 1 May 1985

Chia‐Ming Chu, Peter Karayiannis, Martin J. F. Fowler, Jon Monjardino, Yun‐Fan Liaw, Howard C. Thomas – 1 May 1985 – Hepatitis B virus DNA (HBV DNA) in serum was measured by a Spot hybridization technique in a consecutive series of 79 cases with chronic HBV infection from Taiwan. HBV DNA was found in 96.3% (52/54) of HBeAg‐positive, 66% (2/3) with neither HBeAg or anti‐HBe and in 63.6% (14/22) of anti‐HBe positive patients. The levels of HBV DNA in the HBe‐Ag‐positive patients were significantly higher than in the anti‐HBe positive patients (median, 944 vs. 58 pg per ml, p < 0.001).

Richard J. Kroeger, Roberto J. Groszmann – 1 May 1985 – Present investigations support major contributions from increases in both portal blood flow and portal vascular resistance in the mechanism that maintains portal hypertension. β‐Adrenergic blockers have been shown to reduce the elevated portal blood flow component. The possibility that nitroglycerin administration could reduce the elevated portal vascular resistance component is investigated here. Portal hypertension was induced in rats by a calibrated constriction of the portal vein.

Gary E. Sanders, Robert P. Perrillo – 1 May 1985 – The potential immunoregulatory effects of rosette inhibitory factor (RIF) were evaluated using lymphocyte subpopulations defined by monoclonal antibodies (OKT4, OKT8). Initial experiments indicated that RIF inhibits E‐rosette formation by T cells that provide helper/inducer function (OKT4+). Subsequently, experiments were done to assess if RIF had an inhibitory effect on in vitro immunoglobulin and anti‐HBs production. These studies used peripheral blood mononuclear cells from convalescent and hepatitis B‐vaccinated donors.