Poly(A+)RNA levels of growth‐, differentiation‐ and transformation‐associated genes in the progressive development of hepatocellular carcinoma in the rat

Brian E. Huber, Carole A. Heilman, Snorril S. Thorgeirsson – 1 May 1989 – The development of chemically induced hepatocellular carcinoma in the rat proceeds through a series of premalignant changes that may ultimately progress to a primary malignant tumor. Using the selection technique based on diminished binding of preneoplasic hepatocytes to tissue culture plates precoated with asialofetuin, we have isolated poly(A+)RNA from early preneoplastic foci as well as preneoplastic persistent nodules and primary hepatocellular carcinoma induced by the Solt‐Farber protocol in the Fischer rat.

Hepatic aldehyde dehydrogenase activity in liver diseases, with particular emphasis on alcoholic liver disease

Shujiro Takase, Akira Takada, Minoru Yasuhara, Mikihiro Tsutsumi – 1 May 1989 – Hepatic aldehyde dehydrogenase isozyme activity was measured in 51 patients with various types of liver diseases, including 24 patients with alcoholic liver disease, to elucidate the relationship between hepatic aldehyde dehydrogenase activity and liver disease, especially alcoholic liver disease. The levels of low‐Km and total aldehyde dehydrogenase activity in the liver decreased both in alcoholic and nonalcoholic liver disease patients, who showed an isoelectric focusing pattern of the usual type.

Biologic significance of the detection of HBsAg and HBcAg in liver and tumor from 204 HBsAg‐positive patients with primary hepatocellular carcinoma

Hey‐Chi Hsu, Tsung‐Teh Wu, Jin‐Chuan Sheu, Chieng‐Yen Wu, Tzyy‐Jen Chiou, Chu‐Shue Lee, Ding‐Shinn Chen – 1 May 1989 – Hepatitis B virus surface and core antigens (HBsAg, HBcAg) were examined in the resected primary hepatocellular carcinoma from 204 patients who had HBsAg in serum. Ninety patients had small (<5 cm) and 114 had large hepatocellular carcinoma (>5 cm).

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