Y. Katsuma, S. H. H. Swierenga, U. Khettry, N. Marceau, S. W. French – 1 November 1987 – Mouse and human extracted liver tissue were examined by indirect immunofluorescent staining and transmission electron microscopy in order to study the alteration of cytokeratin intermediate filaments associated with Mallory body formation. Frozen sections of griseofulvin‐fed mouse liver and human liver of primary biliary cirrhosis and primary sclerosing cholangitis were extracted by Triton X‐100 and nuclease.

Yasuhiro Mizoguchi, Hiroko Tsutsui, Keiji Miyajima, Yoshihide Sakagami, Shuichi Seki, Kenzo Kobayashi, Sukeo Yamamoto, Seiji Morisawa – 1 November 1987 – When a small amount of Gram‐negative lipopolysaccharide was intravenously injected into mice which had been injected with heat‐killed Propionibacterium acnes 7 days before, massive hepatic cell necrosis was induced and most of the mice died 24 hr later. However, when prostaglandin E1 was administered with lipopolysaccharide, remarkable improvements in the survival rate and in the histological changes of the liver were observed.

Santos Soberon, Mary P. Pauley, Richard Duplantier, Angelita Fan, Charles H. Halsted – 1 November 1987 – The etiology of malnutrition and the metabolic effect of aggressive nutritional support by enteral feeding were evaluated in patients with moderately severe alcoholic hepatitis.

Masao Yamada, William S. Blaner, Dianne Robert Soprano, Joseph L. Dixon, Hild M. Kjeldbye, Dewitt S. Goodman – 1 November 1987 – Hepatic stellate cells play a quantitatively important role in hepatic retinoid metabolism and storage in rats maintained under normal nutritional conditions. Studies were conducted to further explore the biochemical characteristics of hepatic stellate cells. Stellate cells were isolated in high purity and yield from the livers of normal rats.

Marsha Y. Morgan, Katherine E. Hawley – 1 November 1987 – Lactitol (β‐galactosido‐sorbitol) is a nonabsorbable disaccharide available as a powder which, in open comparison, is as effective as lactulose in the treatment of chronic hepatic encephalopathy, but is better tolerated. Twenty‐five cirrhotic patients experiencing 28 episodes of acute hepatic encephalopathy were randomized blindly to treatment with either lactitol (n = 15) or lactulose (n = 13).

Haim Matzkin – 1 November 1987 – Large‐scale epidemics of non‐B (HBsAg‐negative) hepatitis have occurred in the Israel Defense Forces prior to post‐ and preexposure immune serum globulin administration. Presently, hepatitis morbidity rates have stabilized around 1 to 2 per 1,000. Several years after vaccine initiation, a comparison of epidemiological features was made in order to redefine risk groups.

Jean‐Pierre Villeneuve, Claire Infante‐Rivard, Serge Erlinger, Didier Lebrec – 1 November 1987

Marshall J. Orloff – 1 November 1987 – Nine patients with Budd‐Chiari syndrome (BCS) were treated by a portal systemic shunt. One had thrombosis of the superior mesenteric vein (SMV) and another had complete obstruction of the retrohepatic inferior vena cava (IVC). All other patients had a marked stenosis of the retrohepatic IVC with caval pressure ranging from 12 to 24 mmHg (mean: 17 mmHg). Seven patients had an interprosition mesocaval shunt using an autologous jugular vein. The patient with a thrombosed SMV had a portoartial shunt.

Oliver E. Owen – 1 November 1987 – The purpose of this study was to investigate the effect of interleukin 1 (IL 1) on glucocorticoid‐regulated hepatic metabolism. Steroid binding in liver cytosol, plasma glucose, plasma corticoster‐one, and phosphenolpyruvate carboxykinase (PEPCK) activity were assayed in C3H/HeJ mice after IL 1 administration. Mice received 5 pyrogenic U (PU) of rabbit IL 1 i.p. and were sacrificed 4 hr later.

Thomas D. Boyer, Donald A. Vessey – 1 September 1987 – Inhibition of a major hepatic form of human cationic glutathione S‐transferase by bilirubin, biliverdin, indocyanine green and chenodeoxycholic acid was investigated as a function of pH (range = 6.5 to 9.1). Changes in pH had little effect on the extent of inhibition by indocyanine green. However, inhibition by bilirubin, biliverdin and chenodeoxycholic acid was found to be pH‐dependent, with markedly less inhibition at the high values of pH.