Hepatotoxicity due to allyl alcohol in deermice depends on alcohol dehydrogenase

Steven A. Belinsky, Blair U. Bradford, Donald T. Forman, Edward B. Glassman, Michael R. Felder, Ronald G. Thurman – 1 November 1985 – The role of alcohol dehydrogenase in the hepatic necrosis due to allyl alcohol was studied in two strains of the deermouse, Peromyscus maniculatus. Mice of the alcohol dehydrogenase‐negative (AdhN) strain which lack alcohol dehydrogenase activity were resistant to allyl alcohol toxicity.

On the pathogenesis of focal nodular hyperplasia of the liver

Ian R. Wanless, Carolyn Mawdsley, Ronald Adams – 1 November 1985 – Fifty‐one focal nodular hyperplasia lesions from 36 patients were examined histologically. Serial sections and three‐dimensional models were studied in selected cases. Lesions were multiple in 19% of patients. Thirty‐four patients were female. One case had 11 focal nodular hyperplasia lesions and 7 hemangiomata in the liver. Three had astrocytoma and one had anomalous pulmonary venous drainage.

A randomized study of the effects of adenine arabinoside 5′‐monophosphate (short or long courses) and lymphoblastoid interferon on hepatitis B virus replication

Anna S. F. Lok, David M. Novick, Peter Karayiannis, Arthur A. Dunk, Sheila Sherlock, Howard C. Thomas – 1 November 1985 – A previous randomized controlled study has shown a 30% rate of HBe antigen/antibody serocon‐version within 1 year of a month course of adenine arabinoside‐5′‐monophosphate; no seroconversion occurred in the control group.

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