Histopathology of early and late human hepatic allograft rejection: Evidence of progressive destruction of interlobular bile ducts
John M. Vierling, Robert H. Fennell – 1 November 1985 – Cholestasis and injury of interlobular bile ducts occur during rejection of human hepatic allografts. However, knowledge of the nature and progression of bile duct injury during rejection remains incomplete. To define the role of inflammation in bile duct damage, we assessed the light microscopic appearance of hepatic tissue from selected patients in whom allograft failure was solely due to rejection. Nine patients with rejection were easily separated into two groups based on the duration of the allograft survival.