Martin Hoerner, Ursula J. Behrens, Theresa M. Worner, Ileen Blacksberg, Lawrence F. Braly, Fenton Schaffner, Charles S. Lieber – 1 May 1988 – We recently presented preliminary data indicating the presence of antibodies against acetaldehyde adducts in sera of over 70% of alcoholic patients. To assess the respective roles of liver disease and alcohol consumption as well as the specificity of this immune response, 141 patients in various stages of alcoholic and nonalcoholic liver diseases were tested by a hemagglutination assay.

Rolf Joeres, Hartwig Klinker, Hermann Heusler, Johannes Epping, Walter Zilly, Ernst Richter – 1 May 1988 – The effect of smoking on caffeine elimination was measured in 7 healthy volunteers and in 18 smoking and in 30 nonsmoking patients with alcoholic liver cirrhosis following oral application of 366 mg caffeine. In an intraindividual experiment in smoking healthy probands, caffeine clearance decreased from 118 ± 33 to 77 ± 22 ml per min (p < 0.05) after abstaining cigarette smoking for 3 weeks.

Jacques Metzger, Srinath P. Dore, Bernhard H. Lauterburg – 1 May 1988 – Oxygen‐derived free radicals might play a role in the injury produced by reperfusion of ischemic organs. Since the generation of reactive oxygen species results in an increased formation of glutathione disulfide, we have attempted to document an oxidant stress during reperfusion of ischemic liver by following the hepatic production of glutathione disulfide in vivo and in the perfused rat liver.

Frieder Berr, Frans Stellaard, Alwin Goetz, Claus Hammer, Gustav Paumgartner – 1 May 1988 – The mechanism of ethinylestradiol‐induced biliary secretion of excess cholesterol, a potential causative factor of cholesterol gallstones, is not yet known. It might be related to altered bile acid metabolism, since the rate of cholesterol and phospholipid secreted into bile is thought to be influenced by the hydrophobicity of the bile acid species secreted.

Paul M. Allen – 1 May 1988

Thierry Poynard – 1 May 1988

Chia‐Ming Chu, Wei‐Chue Shyu, Ruey‐Wen Kuo, Yun‐Fan Liaw – 1 May 1988 – It has been suggested that cytotoxic T cells are involved in the recognition and lysis of the infected hepatocytes in chronic hepatitis B virus infection, and that the target antigen is probably HBcAg which is displayed on the hepatocyte membrane during active viral replication. However, studies in other viral infection have demonstrated that cytotoxic T cells recognize viral antigen on the infected cells only in the context of HLA class I antigens.

Juan J. Díaz‐Gil, Gonzalo Sánchez, Carolina Trilla, Pedro Escartín – 1 May 1988 – We determined the concentration of biliprotein in plasma of rats at different times after partial hepatectomy. From the same plasma samples, we purified a liver growth factor previously characterized by our group. When we plotted the 14 points studied, a linear relationship was obtained (r = 0.999; p < 0.001). This result, in addition to our group's recent identification of this liver growth factor as an albumin‐bilirubin complex, strongly suggests that biliprotein is a liver growth factor.

Domenico Pugliese, Samuel S. Lee, Abraham Koshy, Raimondo Cerini, Yves Ozier, Didier Lebrec – 1 May 1988 – In animals, there may exist a hyperemic response in the portal circulation during intravenous administration of hypertonic glucose, but a hemodynamic response of this kind has never been described in man. This study was designed to evaluate if hyperglycemia itself could induce systemic or splanchnic hemodynamic changes in patients with cirrhosis. Sixteen patients with cirrhosis were studied before and during i.v.

Frank Iber – 1 May 1988