Paulette Bioulac‐Sage, Jean Saric, Lilianne Boussarie, Charles Balabaud – 1 November 1985 – In five rats with congenital portacaval shunt, liver atrophy, hyperplastic foci in the periportal zone, atrophic hepatocytes in the centrolobular zone, well‐preserved hepatocyte ultrastructure with abundant rough endoplasmic reticulum, packed mitochondria and numerous peroxisomes were observed as in surgical portacaval shunt. However, portal triads were abnormal in contrast to surgical shunt. In large portal triads, hepatic arteries were prominent, bile ducts numerous and portal veins were lacking.

Harold O. Conn, Jonas Skornicki – 1 November 1985

John M. Vierling, Robert H. Fennell – 1 November 1985 – Cholestasis and injury of interlobular bile ducts occur during rejection of human hepatic allografts. However, knowledge of the nature and progression of bile duct injury during rejection remains incomplete. To define the role of inflammation in bile duct damage, we assessed the light microscopic appearance of hepatic tissue from selected patients in whom allograft failure was solely due to rejection. Nine patients with rejection were easily separated into two groups based on the duration of the allograft survival.

Robert H. Fennell, John M. Vierling – 1 November 1985 – Recognition by biopsy of liver allograft rejection has been less successful than diagnosis of rejection of cardiac and kidney allografts. In a study of 138 failed liver allografts, we recognized damage to small interlobular bile ducts by lymphocytes as the most useful indicator of the presence of rejection. This is a report of the electron microscopic features of three patients with unequivocal allograft rejection. Lymphocytes and occasional granulocytes penetrated the epithelia of interlobular bile ducts.

1 November 1985

Hans Popper – 1 November 1985

Peter A. Berg, Reinhild Klein, Jutta Lindenborn‐Fotinos, M. Manns, G. Gerken, T. Poralla, K.‐H. Meyer zum Büschenfelde, Marshall M. Kaplan – 1 November 1985

Wolfgang G. Dippold, Hans‐Peter Dienes, Alexander Knuth, Walter Sachsse, Winfried Prellwitz, Dieter Bitter‐Suermann, Karl‐Hermann Meyer zum Büschenfelde – 1 November 1985 – A human hepatoma cell line, associated with thorotrast exposure, from an hepatitis B markernegative patient was established as a permanent cell line (Mz‐Hep‐1) in tissue culture. Histology of the primary tumor, as well as phase contrast, transmission and scanning electron microscopy of the cultured cells showed typical characteristics of liver cells.

Stanley B. Benjamin, Zachary D. Goodman, Kamal G. Ishak, Hyman J. Zimmerman, Nelson S. Irey – 1 November 1985 – Hepatic histopathology and clinical‐pathologic correlations were studied in 77 patients who met clinical criteria for halothane hepatotoxicity. They were divided into groups based on the type of surgery (minor or major) and outcome (nonfatal, biopsy group or fatal, autopsy group).

Russell D. Dorado, Eduardo A. Porta, Therese M. Aquino – 1 November 1985 – Seven groups of female Sprague‐Dawley rats (˜200 gm initial body weight) were injected i.p. with a single subcarcinogenic dose of diethylnitrosamine (40 mg per kg body weight) between 8 to 10 hr after partial hepatectomy, and after a recovery period of 3 weeks (herein called induction stage) received 0.05% phenobarbital in the diet for the rest of the experiment (promotion stage).