John Wahren, Roberto J. Groszmann, Jaime Bosch – 1 January 1986

Gerald Y. Minuk.M.D., Thomas A. Sherman, Eldon A. Shaffer, Seamus K. Kelly – 1 January 1986 – Acute fulminant hepatitis was induced in 55 healthy adult male rabbits with the potent hepatotoxin galactosamine hydrochloride (3.75 mmoles per kg i.v.). Control rabbits (n = 27) were divided into three groups: Group I (n = 10) underwent sham surgery for placement of an indwelling central venous catheter; Group II (n = 9) received 5% dextrose and water via an indwelling central venous catheter, and Group III (n = 8) received daily intramuscular injections of 0.9% sodium chloride.

Namita Roy Chowdhury, Irwin M. Arias, Mitchell Lederstein, Jayanta Roy Chowdhury – 1 January 1986 – To determine whether the isoform of UDP‐glucuronosyltransferase which catalyzes the formation of bilirubin monoglucuronide also mediates the formation of bilirubin diglucuronide and other specific sugar conjugates of bilirubin, Wistar rats were treated with clofibrate (300 mg per kg i.p. × 7 days); this resulted in a 200% increase in hepatic transferase specific activity for bilirubin.

Manuel Rodriguez, Ramon Perez, Pedro Sala, Luis Rodrigo, Leonard B. Seeff, Antonio Ponzetto, Jay H. Hoofnagle, John L. Gerin – 1 January 1986

V. Arroyo, A. Rimola, J. Felisart, J. Cabrera, William G. Rector – 1 January 1986

Guadalupe Garcia‐Tsao, Norman D. Grace, Roberto J. Groszmann, Harold O. Conn, Max M. Bermann, Michael J. C. Patrick, Steven S. Morse, Jeanne L. Alberts – 1 January 1986 – The present study was designed to investigate the effect of propranolol on portal pressure of patients with alcoholic cirrhosis and portal hypertension and to correlate these effects with clinical and laboratory parameters. The mean baseline hepatic venous pressure gradient in the 50 patients studied was of 18.2 ± 4.1 mm Hg.

Jean‐Charles Delchier, Paul Benfredj, Anne‐Marie Preaux, Jean‐Michel Metreau, Daniel Dhumeaux – 1 January 1986 – Gallbladder bile collected by duodenal intubation or during surgery was examined microscopically in patients who werefree of stones and in patients with proven stones. None of the 16 patients free of stones had cholesterol monohydrate crystals or calcium bilirubinate granules in bile.

Maud I. Cleton, Jan W. Sindram, Louk H. P. M. Rademakers, Floris M. J. Zuyderhoudt, Willem C. De Bruijn, Joannes J. M. Marx – 1 January 1986 – Ferritin‐like particles were observed in bile canaliculi of patients with iron overload. These particles have been further investigated by: (1) a staining method enhancing the size and contrast of ferritin protein, and (2) electronprobe microanalysis detecting the presence of the elements iron and phosphorus.

Marc L. Berger, Harshika Bhatt, Burton Combes, Ronald W. Estabrook – 1 January 1986 – CCl4 is proposed to induce cellular injury through its metabolites that are generated by a cytochrome P‐450 dependent step. These free radical products can interact with membrane structures, thereby generating lipid peroxides. The latter process has been implicated as a major mechanism of CCl4 hepatoxicity, although this relationship has been difficult to demonstrate when using isolated hepatocyte preparations.

Linus Chang, Peter Clifton, Philip Barter, Malcolm Mackinnon, M.D. – 1 January 1986 – Severe liver disease may be associated with a reduction in plasma concentration of high density lipoprotein and an impairment of plasma cholesterol esterification. These changes were confirmed in two patients with severe acute on chronic alcoholic liver disease.