Prognostic significance of serum bile acids in cirrhosis

Gerd A. Mannes, M.D., Christian Thieme, Frans Stellaard, Tiancai Wang, Tilman Sauerbruch, Gustav Paumgartner – 1 January 1986 – The value of serum bile acid concentrations for predicting prognosis in cirrhotics was compared with the prognostic significance of clinical and laboratory findings in a prospective 1‐year study of 76 patients with cirrhosis. A commercial radioimmunoassay for total serum‐conjugated primary bile acids was used. Of 76 patients, 16 died within the follow‐up period.

Liver biopsy immunotyping to characterize lymphoid malignancies

Christopher J. Verdi, Thomas M. Grogan, Robert Protell, Lynne Richter, Catherine Rangel – 1 January 1986 – To determine the feasibility of liver biopsy immunotyping to characterize hepatic lymphoid malignancies, we employed a panel of monoclonal antibodies on snapfrozen hepatic tissue from 18 patients. Six patients proved to have a histologic diagnosis of lymphoid malignancy. By using free avidin and biotin‐blocking reagents to block endogenous biotin, followed by standard immunochemistry, immunotyping was successful in all six cases.

A comparative study of the effects of insulin/glucagon infusions, parenteral amino acids and high dose corticosteroids on survival in a rabbit model of acute fulminant hepatitis

Gerald Y. Minuk.M.D., Thomas A. Sherman, Eldon A. Shaffer, Seamus K. Kelly – 1 January 1986 – Acute fulminant hepatitis was induced in 55 healthy adult male rabbits with the potent hepatotoxin galactosamine hydrochloride (3.75 mmoles per kg i.v.). Control rabbits (n = 27) were divided into three groups: Group I (n = 10) underwent sham surgery for placement of an indwelling central venous catheter; Group II (n = 9) received 5% dextrose and water via an indwelling central venous catheter, and Group III (n = 8) received daily intramuscular injections of 0.9% sodium chloride.

Substrates and products of purified rat liver bilirubin UDP ‐ glucuronosyltransferase

Namita Roy Chowdhury, Irwin M. Arias, Mitchell Lederstein, Jayanta Roy Chowdhury – 1 January 1986 – To determine whether the isoform of UDP‐glucuronosyltransferase which catalyzes the formation of bilirubin monoglucuronide also mediates the formation of bilirubin diglucuronide and other specific sugar conjugates of bilirubin, Wistar rats were treated with clofibrate (300 mg per kg i.p. × 7 days); this resulted in a 200% increase in hepatic transferase specific activity for bilirubin.

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